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Independent Research 1. Andrews, I. P.; Kwon, O. "Highly Efficient Palladium-Catalyzed Hydrostannation of Ethyl Ethynyl Ether" Tetrahedron Lett. 2008, 49, 7097. doi:10.1016/j.tetlet.2008.09.147
2. Creech, G. S.; Zhu, X.; Fonovic, B.; Travis, D.; Kwon, O.
"Theory-Guided
3. Watanabe, M.; Fiji, H. D. G.; Guo, L.; Chan, L.; Kinderman, S. S.; Slamon, D. J.; Kwon, O.; Tamanoi, F. "Inhibitors of protein geranylgeranyltransferase-I and rab geranylgeranyltransferase identified from a library of allenoate derived compounds" J. Biol. Chem. 2008, 283(15), 9571.DOI: 10.1074/jbc.M706229200
[Abstract][PDF][Supporting
Info] This paper has been selected for 'Faculty of 1000 Biology': see http://www.f1000biology.com/article/id/1103837
4. Creech,
G. S.; Kwon, O. "Alcohol-Assisted Phosphine Catalysis: One-Step [Abstract][HTML][PDF][Supporting Info] This paper has been featured as a Most-Accessed Article for the first-quarter of 2008 on the ACS Publication website
5. Tran, Y. S.; Kwon, O. "Phosphine-Catalyzed [4 + 2] Annulation: Synthesis of Cyclohexenes" J. Am. Chem. Soc. 2007, 129, 12632. DOI: 10.1021/ja0752181 [Abstract][HTML][PDF][Supporting
Info]
6. Sriramurthy, V.; Barcan, G. A.; Kwon, O. ""Bisphosphine-Catalyzed Mixed Double-Michael Reactions: Asymmetric Synthesis of Oxazolidines, Thiazolidines, and Pyrrolidines" J. Am. Chem. Soc. 2007, 129, 12928. DOI: 10.1021/ja073754n This paper has been featured as a Synstory In SYNFORM, Volume 2008, A10-A12
This publication has been
Highlighted in synfacts, 2008,
1,
19 [Abstract][HTML][PDF][Supporting
Info]
7. Henry, C. E.; Kwon, O. "Phosphine-Catalyzed Synthesis of Highly Functionalized Coumarins" Org. Lett. 2007, 9, 3069. DOI: 10.1021/ol071181d
This publication has been
Highlighted in synfacts, 2007, 11, 1145 [Abstract][HTML][PDF][Supporting Info]
8. Zhu, X.-F.; Henry, C. E.; Kwon, O. "Stable Tetravalent Phosphonium Enolate Zwitterions" J. Am. Chem. Soc. 2007, 129, 6722. DOI: 10.1021/ja071990s
[Abstract][HTML][PDF][Supporting
Info]
9. Castellano, S.; Fiji, H. D. G. Kinderman, S. S.; Watanabe, M.; De Leon, P.; Tamanoi, F.; Kwon, O. "Small-Molecule Inhibitors of Protein Geranylgeranyltransferase Type I " J. Am. Chem. Soc. 2007, 129, 5843. DOI: 10.1021/ja070274n [Abstract][HTML][PDF][Supporting Info]
10. Mercier, E.; Fonovic, B.; Henry, C.; Kwon, O.; Dudding, T. "Phosphine Triggered [3+2] Allenoate-Acrylate Annulation: A Mechanistic Enlightenment" Tetrahedron Lett. 2007, 48, 3617. [PDF]
11. Dudding, T.; Kwon, O.; Mercier, E. “Theoretical Rationale for Regioselection in Phosphine Catalyzed Allenoate Additions to Acrylates, Imines and Aldehydes” Org. Lett. 2006, 8, 3643. DOI: 10.1021/ol061095y [Abstract][HTML][PDF][Supporting Info]
12. Tran, Y. S.; Kwon, O. “An Application of the Phosphine-Catalyzed [4 + 2] Annulation in Indole Alkaloid Synthesis: Formal Syntheses of (±)-Alstonerine and (±)-Macroline” Org. Lett. 2005, 7, 4289-4291. DOI: 10.1021/ol051799s [Abstract][HTML][PDF][Supporting Info]
13. Zhu, X.; Schaffner, A.; Li, R. C.; Kwon, O. “Phosphine-Catalyzed Synthesis of 6-Substituted 2-Pyrones: Manifestation of E/Z-Isomerism in the Zwitterionic Intermediate” Org. Lett. 2005, 7, 2977-2980. DOI: 10.1021/ol050946j [Abstract][HTML][PDF][Supporting Info]
14. Zhu, X.; Henry, C. E.; Wang, J.; Dudding, T.; Kwon, O. “A Phosphine-Catalyzed Synthesis of 1,3- Dioxan-4-ylidenes” Org. Lett. 2005, 7, 1387-1390. DOI: 10.1021/ol050203y [Abstract][HTML][PDF][Supporting Info]
15 Zhu, X.; Henry, C. E.; Kwon, O. “A highly diastereoselective synthesis of 3-carbethoxy-2,5-disubstituted-3-pyrrolines by phosphine catalysis” Tetrahedron, 2005, 61, 6276-6282.
16. Du, X.; Chu, H. V.; Kwon, O. “A concise synthesis of the functionalized [5–7–6] tricyclic skeleton of guanacastepene A” Tetrahedron Lett. 2004, 45, 8843-8846.
17. Du, X.; Chu, H. V.; Kwon, O. "Synthesis of the [5-7-6] Tricyclic Core of Guanacastepene A via an Intramolecular Mukaiyama Aldol Reaction" Org. Lett. 2003, 5, 1923–1926. DOI: 10.1021/ol0344873 [Abstract][HTML][PDF][Supporting Info]
18. Zhu, X.; Lan, J.; Kwon, O. "An Expedient Phosphine-Catalyzed [4 + 2] Annulation: Synthesis of Highly Functionalized Tetrahydropyridines" J. Am. Chem. Soc. 2003, 125, 4716–4717. DOI: 10.1021/ja0344009 [Abstract][HTML][PDF][Supporting Info]
In the News 1. "Putting the Combinatorial back into Combinatorial Drug Discovery - Reimagining Early Stage Drug Discovery" Found In Translation: The Life Science Newsletter on Translational Medicine 2006. [PDF]
Postdoctoral Work
19. Schmidt, D. R.; Kwon, O.; Schreiber, S. L. "Macrolactones in Diversity-Oriented Synthesis: Preparation of a Pilot Library and an Exploration of Factors Controlling Macrocyclization" J. Comb. Chem. 2004, 6, 286–292. [Abstract][HTML][PDF][Supporting Info]
20. Kwon, O.; Park, S. B.; Schreiber, S. L. "Skeletal Diversity via a Branched Pathway: Efficient Synthesis of 29,400 Discrete, Polycyclic Compounds and Their Arraying into Stock Solutions" J. Am. Chem. Soc. 2002, 124, 13402–13404. [Abstract][HTML][PDF][Supporting Info]
Graduate School
21. Kwon, O.; Su, D.; Meng, D.; Deng, W.; D’Amico, D. C.; Danishefsky, S. J. “A Stereospecific Geminal Alkylation Scheme En Route To CP-225,917 and CP-263,114” Angew. Chem., Int. Ed. 1998, 37, 1880–1882.
22. Kwon, O.; Su, D.; Meng, D.; Deng, W.; D’Amico, D. C.; Danishefsky, S. J. “Total Syntheses of CP-225,917 and CP-263,114: Creation of a Matrix Structure By Sequential Aldol Condensation and Intramolecular Heck Ring Closure” Angew. Chem., Int. Ed. 1998, 37, 1877–1880.
23. Kwon, O.; Danishefsky, S. J. “Synthesis of Asialo GM1. New Insights in the Application of Sulfonamidoglycosidation in Oligosaccharide Assembly: Subtle Proximity Effects in the Stereochemical Governance of Glycosidation” J. Am. Chem. Soc. 1998, 120, 1588–1599. [Abstract][HTML][PDF][Supporting Info]
24. Park, T. K.; Kim, I. J.; Hu, S.; Bilodeau, M. T.; Randolf, J. T.; Kwon, O.; Danishefsky, S. J. “Total Synthesis and Proof of Structure of a Human Breast Tumor (Globo-H) Antigen” J. Am. Chem. Soc. 1996, 118, 11488–11500. [Abstract][HTML][PDF][Supporting Info]
25. Lee, E.; Lee, Y. R.; Moon, B.; Kwon, O.; Shim, M. S.; Yun, J. S. “Oxyanion Orientation in Anionic Oxy-Cope Rearrangement” J. Org. Chem. 1994, 59, 1444–1456. [Abstract][PDF] |
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