Garg Research Group

Natural Product Synthesis & Reaction Discovery

 

Independent Career


89. Understanding and Interrupting the Fischer Azaindolization Reaction.

      Bryan J. Simmons, Marie Hoffmann, Pier Alexandre Champagne, Elias Picazo, Katsuya Yamakawa, Lucas A. Morrill, K. N. Houk, and Neil K.
      Garg. J. Am. Chem. Soc. 2017, Article ASAP.

     Abstract | PDF | Supporting Information




88. Engineering the Biocatalytic Selectivity of Iridoid Production in Saccharomyces cerevisiae.

      John M. Billingsley, Anthony B. DeNicola, Joyann S. Barber, Man-Cheng Tang, Joe Horecka, Angela Chu, Neil K. Garg, and Yi Tang.
      Metab. Eng. 2017, 44, 117–125.

     Abstract | PDF | Supporting Information




  1. 86.Conjugated Trimeric Scaffolds Accessible from Indolyne Cyclotrimerizations: Synthesis, Structures, and Electronic Properties.

      Janice B. Lin, Tejas K. Shah, Adam E. Goetz, Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc. 2017, 139, 10447–10455.

      Abstract | PDF | Supporting Information




83. Enantioselective Nickel-Catalyzed Mizoroki–Heck Cyclizations to Generate Quaternary Stereocenters.

      Jean-Nicolas Desrosiers, Jialin Wen, Sergei Tcyrulnikov, Soumik Biswas, Bo Qu, Liana Hie, Dmitry Kurouski, Ling Wu, Nelu Grinberg, Nizar

      Haddad, Carl A. Busacca, Nathan K. Yee, Jinhua J. Song, Neil K. Garg, Xumu Zhang, Marisa C. Kozlowski, and Chris H. Senanayake.

      Org. Lett. 2017, 19, 3338–3341.

      Abstract | PDF | Supporting Information




82. Kinetic Modeling of the Nickel-Catalyzed Esterification of Amides.

       Nicholas A. Weires, Daniel D. Caspi, and Neil K. Garg. ACS Catal. 2017, 7, 4381–4385.

      Abstract | PDF | Supporting Information | ACS Editor’s Choice (June 4, 2017) | C&E News



79. Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases.

      Michio Sato, Jacob E. Dander, Chizuru Sato, Yiu-sun Hung, Shu-Shan Gao, Man-Cheng Tang, Leibniz Hang, Jaclyn M. Winter, Neil K. Garg,
      Kenji Watanabe, and Yi Tang
. J. Am. Chem. Soc. 2017, 39, 53175320.

      Abstract | PDF | Supporting Information



77. Enzyme-Catalyzed Stereoselective Intramolecular Hydroalkoxylation.

      Shu-Shan Gao, Marc Garcia-Borràs, Joyann S. Barber, Yang Hai, Abing Duan, Neil K. Garg, K. N. Houk, and Yi Tang. J. Am. Chem. Soc.
     
2017, 139, 36393642.

      Abstract | PDF | Supporting Information | SYNFACTS Highlights




  1. 74.Expanding the ROMP Toolbox: Synthesis of Air-Stable Benzonorbornadiene Polymers by Aryne Chemistry.

      Jose M. Medina, Jeong Hoon Ko, Heather D. Maynard, and Neil K. Garg. Macromolecules 2017, 50, 580–586.

     Abstract | PDF | Supporting Information




72. Nickel-Catalyzed Esterification of Aliphatic Amides.

      Liana Hie, Emma L. Baker, Sarah M. Anthony, Jean-Nicolas Desrosiers, Chris Senanayake, and Neil K. Garg.
      Angew. Chem. Int. Ed. 2016, 55, 15129–15132.

      Abstract | PDF | Supporting Information




  1. 70.Quantification of the Electrophilicity of Benzyne and Related Intermediates.

      Noah F. Fine Nathel, Lucas A. Morrill, Herbert Mayr, and Neil K. Garg. J. Am. Chem. Soc. 2016, 138, 10402–10405.

      Abstract | PDF | Supporting Information



  1. 69.Construction of Quaternary Stereocenters via Nickel-Catalyzed Heck Cyclizations.

      Jean-Nicolas Desrosiers, Liana Hie, Soumik Biswas, Olga V. Zatolochnaya, Sonia Rodriguez, Heewon Lee, Nelu Grinberg, Nizar Haddad,

      Nathan K. Yee, Neil K. Garg, and Chris H. Senanayake.

      Angew. Chem. Int. Ed. 2016, 55, 11921–11924.

      Abstract | PDF | Supporting Information




64. P450-Mediated Coupling of Indole Fragments to Forge Communesin and Unnatural Isomers.

      Hsiao-Ching Lin, Travis C. McMahon, Ashay Patel, Michael Corsello, Adam Simon, Wei Xu, Muxun Zhao, K. N. Houk, Neil K. Garg,

      and Yi Tang. J. Am. Chem. Soc. 2016, 138, 4002–4005.

        Abstract | PDF | Supporting Information




  1. 62.Nitrone Cycloadditions of 1,2-Cyclohexadiene.

      Joyann S. Barber, Evan D. Styduhar, Hung V. Pham, Travis C. McMahon, K. N. Houk, and Neil K. Garg.

      J. Am. Chem. Soc. 2016, 138, 2512–2515.

      Abstract | PDF | Supporting Information


     


  1. 60.Nickel-Catalyzed Activation of Acyl C–O Bonds of Methyl Esters.

      Liana Hie, Noah F. Fine Nathel, Xin Hong, Yun-Fang Yang, K. N. Houk, and Neil K. Garg. Angew. Chem. Int. Ed. 2016, 55, 2810–2814.

      Abstract | PDF | Supporting Information




58. Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast.

      Man-Cheng Tang, Hsiao-Ching Lin, Dehai Li, Yi Zou, Jian Li, Wei Xu, Ralph A. Cacho, Maureen E. Hillenmeyer, Neil K. Garg, and Yi Tang.

      J. Am. Chem. Soc. 2015, 137, 13724–13727.

      Abstract | PDF | Supporting Information




  1. 57.Conversion of Amides to Esters by the Nickel-Catalyzed Activation of Amide C–N Bonds.
    Liana Hie, Noah F. Fine Nathel, Tejas K. Shah, Emma L. Baker, Xin Hong, Yun-Fang Yang, Peng Liu, K. N. Houk, and Neil K. Garg.
    Nature 2015, 524, 79–83.
    Abstract | PDF | Supporting Information | C&E News | Nat. Chem. Highlight | Angew. Chem. Int. Ed. Highlight | Synform | C&E News Top

      Research of 2015 | Org. Chem. Highlights


  1. 55.Generation and Regioselective Trapping of a 3,4-Piperidyne for the Synthesis of Functionalized Heterocycles.
    Travis C. McMahon, Jose M. Medina, Yun-Fang Yang, Bryan J. Simmons, K. N. Houk, and Neil K. Garg.
    J. Am. Chem. Soc. 2015, 137, 4082–4085.  

       Abstract | PDF | Supporting Information | JACS Spotlight | C&E News



  1. 54.Elucidation of the Concise Biosynthetic Pathway of the Communesin Indole Alkaloids.
    Hsiao-Ching Lin, Grace Chiou, Yit-Heng Chooi, Travis C. McMahon, Wei Xu, Neil K. Garg, and Yi Tang.
    Angew. Chem. Int. Ed. 2015, 54, 3004–3007. (Selected as a Very Important Paper)

       Abstract | PDF



  1. 53.Computational Predictions of Substituted Benzyne and Indolyne Regioselectivities.
    Elias Picazo, K. N. Houk, and Neil K. Garg. Tetrahedron Lett. 2015, 56, 3511–3514. (Special issue for Professor Harry Wasserman)

      Abstract | PDF



  1. 50.The Role of Aryne Distortions, Steric Effects, and Charges on Regioselectivities in Aryne Reactions.
    Jose M. Medina, Joel L. Mackey, Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc. 2014, 136, 15798–15805.
    Abstract | PDF | Supporting Information



  1. 48.Cycloadditions of Cyclohexynes and Cyclopentyne.
    Jose M. Medina, Travis C. McMahon, Gonzalo Jiménez-Osés, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc. 2014, 136, 14706–14709.

       Abstract | PDF | Supporting Information

      




  1. 37.Expanding the Structural Diversity of Polyketides by Exploring the Cofactor Tolerance of an Inline Methyltransferase Domain.
    Jaclyn M. Winter, Grace Chiou, Ian R. Bothwell,, Wei Xu, Neil K. Garg, Minkui Luo, and Yi Tang. Org. Lett. 2013, 15, 3774–3777.
    Abstract | PDF | Supporting Information




  1. 36.EcdGHK are Three Tailoring Iron Oxygenases for Amino Acid Building Blocks of the Echinocandin Scaffold.
    Wei Jiang, Ralph A. Cacho, Grace Chiou, Neil K. Garg, Yi Tang, and Christopher T. Walsh. J. Am. Chem. Soc. 2013, 135, 4457–4466.
    Abstract | PDF | Supporting Information





  1. 32.Identification and Characterization of the Chaetoviridin and Chaetomugilin Gene Cluster in Chaetomium globosum Reveal Dual Functions of an Iterative Highly-Reducing Polyketide Synthase.
    Jaclyn M. Winter, Michio Sato, Satoru Sugimoto, Grace Chiou, Neil K. Garg, Yi Tang, and Kenji Watanabe.
    J. Am. Chem. Soc. 2012, 134, 17900–17903.
    Abstract | PDF | Supporting Information



  1. 30.Steric Effects Compete with Aryne Distortion to Control Regioselectivities of Nucleophilic Additions to 3-Silylarynes.
    Sarah M. Bronner, Joel L. Mackey, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc. 2012, 134, 13966–13969.
    Abstract | PDF | Supporting Information




  1. 25.An Efficient Computational Model to Predict the Synthetic Utility of Heterocyclic Arynes.
    Adam E. Goetz, Sarah M. Bronner, Jordan D. Cisneros, Joshua M. Melamed, Robert S. Paton, K. N. Houk, and Neil K. Garg.
    Angew. Chem. Int. Ed. 2012, 51, 2758–2762.
    Abstract | PDF | Supporting Information


  1. 24.Total Synthesis of Oxidized Welwitindolinones and (–)-N-Methylwelwitindolinone C Isonitrile.
    Kyle W. Quasdorf, Alexander D. Huters, Michael W. Lodewyk, Dean J. Tantillo, and Neil K. Garg. J. Am. Chem. Soc. 2012, 134, 1396–1399.
    Abstract | PDF | Supporting Information



  1. 20.Nickel-Catalyzed Amination of Aryl Carbamates and Sequential Site-Selective Cross-Couplings.
    Tehetena Mesganaw, Amanda L. Silberstein, Stephen D. Ramgren, Noah F. Fine Nathel, Xin Hong, Peng Liu, and Neil K. Garg.
    Chem. Sci. 2011, 2, 1766–1771.
    Abstract | PDF | Supporting Information


  1. 18.Suzuki–Miyaura Cross-Coupling of Aryl Carbamates and Sulfamates: Experimental and Computational Studies.
    Kyle W. Quasdorf, Aurora Antoft-Finch, Peng Liu, Amanda L. Silberstein, Anna Komaromi, Tom Blackburn, Stephen D. Ramgren, K. N. Houk, Victor Snieckus, and Neil K. Garg.
    J. Am. Chem. Soc. 2011, 133, 6352–6363.
    Abstract | PDF | Supporting Information | Synfacts Highlight



  1. 17.Why Do Some Fischer Indolizations Fail?
    Nihan Çelebi-Olcüm, Ben W. Boal, Alexander D. Huters, Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc. 2011, 133, 5752–5755.
    Abstract | PDF | Supporting Information



  1. 15.A Fungal Nonribosomal Peptide Synthetase Module that can Synthesize Thiopyrazines.
    Kangjian Qiao, Hui Zhou, Wei Xu, Wenjun Zhang, Neil K. Garg, and Yi Tang. Org. Lett. 2011, 13, 1758–1761.
    Abstract | PDF | Supporting Information






  1. 13.Nickel-Catalyzed Cross-Couplings Involving Carbon–Oxygen Bonds.
    Brad M. Rosen, Kyle W. Quasdorf, Daniella A. Wilson, Na Zhang, Ana-Maria Resmerita, Neil K. Garg, and Virgil Percec.
    Chem. Rev. 2011, 111, 1346–1416 (invited contribution).
    Abstract | PDF


  1. 11.Indolyne Experimental and Computational Studies: Synthetic Applications and Origins of Selectivities of Nucleophilic Additions.
    G-Yoon J. Im, Sarah M. Bronner, Adam E. Goetz, Robert S. Paton, Paul H.-Y. Cheong, K. N. Houk, and Neil K. Garg.
    J. Am. Chem. Soc. 2010, 132, 17933–17944.
    Abstract | PDF | Supporting Information



  1. 7.Indolyne and Aryne Distortions and Nucleophilic Regioselectivities.
    Paul H.-Y. Cheong, Robert S. Paton, Sarah M. Bronner, G-Yoon J. Im, Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc. 2010, 132, 1267–1269.
    Abstract | PDF | Supporting Information | Chemistry World Highlight

 

Publications (Research Contributions)

View By Category

|

|

|

|