Garg Research Group

Natural Product Synthesis & Reaction Discovery

 

Independent Career


  1. 86.Conjugated Trimeric Scaffolds Accessible from Indolyne Cyclotrimerizations: Synthesis, Structures, and Electronic Properties.

      Janice B. Lin, Tejas K. Shah, Adam E. Goetz, Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc. 2017, 139, 10447–10455.

      Abstract | PDF | Supporting Information




84. Total Synthesis of ()-Tubingensin B Enabled by the Strategic Use of an Aryne Cyclization.

     Michael A. Corsello, Junyong Kim, and Neil K. Garg. Nat. Chem. 2017, 9, 944–949.

     Abstract | PDF | Supporting Information | Synfacts Highlight

































  1. 74.Expanding the ROMP Toolbox: Synthesis of Air-Stable Benzonorbornadiene Polymers by Aryne Chemistry.

      Jose M. Medina, Jeong Hoon Ko, Heather D. Maynard, and Neil K. Garg. Macromolecules 2017, 50, 580–586.

     Abstract | PDF | Supporting Information




  1. 70.Quantification of the Electrophilicity of Benzyne and Related Intermediates.

      Noah F. Fine Nathel, Lucas A. Morrill, Herbert Mayr, and Neil K. Garg. J. Am. Chem. Soc. 2016, 138, 10402–10405.

      Abstract | PDF | Supporting Information




65. Expanding the Strained Alkyne Toolbox: Generation and Utility of Oxygen-Containing Strained Alkynes.

        Tejas K. Shah, Jose M. Medina, and Neil K. Garg. J. Am. Chem. Soc. 2016, 138, 4948–4954.

      Abstract | PDF | Supporting Information





  1. 63.Synthetic Studies Pertaining to the 2,3-Pyridyne and 4,5-Pyrimidyne.

      Jose M. Medina, Moritz K. Jackl, Robert B. Susick, and Neil K. Garg. Tetrahedron 2016, 72, 3629–3634.

      Abstract | PDF | Supporting Information




  1. 62.Nitrone Cycloadditions of 1,2-Cyclohexadiene.
    Joyann S. Barber, Evan D. Styduhar, Hung V. Pham, Travis C. McMahon, K. N. Houk, and Neil K. Garg.

      J. Am. Chem. Soc. 2016, 138, 2512–2515.

      Abstract | PDF | Supporting Information

     


  1. 55.Generation and Regioselective Trapping of a 3,4-Piperidyne for the Synthesis of Functionalized Heterocycles.
    Travis C. McMahon, Jose M. Medina, Yun-Fang Yang, Bryan J. Simmons, K. N. Houk, and Neil K. Garg.
    J. Am. Chem. Soc. 2015, 137, 4082–4085.  

       Abstract | PDF | Supporting Information | JACS Spotlight | C&E News



  1. 53.Computational Predictions of Substituted Benzyne and Indolyne Regioselectivities.
    Elias Picazo, K. N. Houk, and Neil K. Garg. Tetrahedron Lett. 2015, 56, 3511–3514. (Special issue for Professor Harry Wasserman)

      Abstract | PDF



  1. 51.Pyridynes and Indolynes as Building Blocks for Functionalized Heterocycles and Natural Products.
    Adam E. Goetz, Tejas K. Shah and Neil K. Garg. Chem. Commun. 2015, 51, 34–45. (Featured Article)
    Abstract | PDF



  1. 50.The Role of Aryne Distortions, Steric Effects, and Charges on Regioselectivities in Aryne Reactions.
    Jose M. Medina, Joel L. Mackey, Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc. 2014, 136, 15798–15805.
    Abstract | PDF | Supporting Information



  1. 49.Total Synthesis of (–)-N-Methylwelwitindolinone B Isothiocyanate via a Chlorinative Oxabicycle Ring-Opening Strategy.
    Nicholas A. Weires, Evan D. Styduhar, Emma L. Baker, and Neil K. Garg. J. Am. Chem. Soc. 2014, 136, 14710–14713.
    Abstract | PDF | Supporting Information | Synfacts Highlight



  1. 48.Cycloadditions of Cyclohexynes and Cyclopentyne.
    Jose M. Medina, Travis C. McMahon, Gonzalo Jiménez-Osés, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc. 2014, 136, 14706–14709.

       Abstract | PDF | Supporting Information

      



  1. 43.Concise Enantiospecific Total Synthesis of Tubingensin A.
    Adam E. Goetz, Amanda L. Silberstein, Michael A. Corsello, and Neil K. Garg. J. Am. Chem. Soc. 2014, 136, 3036–3039.
    Abstract | PDF | Supporting Information | Synfacts Highlight | Organic Chemistry Portal



  1. 42.Total Syntheses of Indolactam Alkaloids (–)-Indolactam V, (–)-Pendolmycin, (–)-Lyngbyatoxin A, and (–)-Teleocidin A-2.
    Noah F. Fine Nathel, Tejas K. Shah, Sarah M. Bronner, and Neil. K. Garg. Chem. Sci. 2014, 5, 2184–2190.
    Abstract | PDF | Supporting Information



  1. 41.Enabling the Use of Heterocyclic Arynes in Chemical Synthesis.
    Adam E. Goetz and Neil K. Garg. J. Org. Chem. 2014, 79, 846–851.
    Abstract | PDF



  1. 39.Enantiospecific Total Synthesis of N-Methylwelwitindolinone D Isonitrile.
    Evan D. Styduhar, Alexander D. Huters, Nicholas A.
    Weires, and Neil K. Garg. Angew. Chem. Int. Ed. 2013, 52, 12422–12425.
    Abstract | PDF | Supporting Information | Synfacts Highlight



  1. 34.Regioselective Reactions of 3,4-Pyridynes Enabled by the Aryne Distortion Model.
    Adam E. Goetz and Neil K. Garg. Nat. Chem. 2013, 5, 54–60.
    Abstract | PDF | Supporting Information | Synfacts Highlight



  1. 30.Steric Effects Compete with Aryne Distortion to Control Regioselectivities of Nucleophilic Additions to 3-Silylarynes.
    Sarah M. Bronner, Joel L. Mackey, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc. 2012, 134, 13966–13969.
    Abstract | PDF | Supporting Information




  1. 26.Total Syntheses of the Elusive Welwitindolinones with Bicyclo[4.3.1]cores.
    Alexander D. Huters, Evan D. Styduhar, and Neil K. Garg. Angew. Chem. Int. Ed. 2012, 51, 3758–3765.
    Abstract | PDF



  1. 25.An Efficient Computational Model to Predict the Synthetic Utility of Heterocyclic Arynes.
    Adam E. Goetz, Sarah M. Bronner, Jordan D. Cisneros, Joshua M. Melamed, Robert S. Paton, K. N. Houk, and Neil K. Garg.
    Angew. Chem. Int. Ed. 2012, 51, 2758–2762.
    Abstract | PDF | Supporting Information



  1. 24.Total Synthesis of Oxidized Welwitindolinones and (–)-N-Methylwelwitindolinone C Isonitrile.
    Kyle W. Quasdorf, Alexander D. Huters, Michael W. Lodewyk, Dean J. Tantillo, and Neil K. Garg. J. Am. Chem. Soc. 2012, 134, 1396–1399.
    Abstract | PDF | Supporting Information     

                  


  1. 22.Total Synthesis of (–)-N-Methylwelwitindolinone C Isothiocyanate.
    Alexander D. Huters, Kyle W. Quasdorf, Evan D. Styduhar, and Neil K. Garg. J. Am. Chem. Soc. 2011, 133, 15797–15799.
    Abstract | PDF | Supporting Information | C&E News Highlight | Synfacts Highlight | Nature Chemistry | Organic Chemistry Portal
































  1. 21.Understanding and Modulating Indolyne Regioselectivities.
    Sarah M. Bronner, Adam E. Goetz, and Neil K. Garg. Synlett 2011, 18, 2599–2604. (invited SYNPACTS article)
    Abstract | PDF




  1. 16.Overturning Indolyne Regioselectivities and Synthesis of Indolactam V.
    Sarah M. Bronner, Adam E. Goetz, and Neil K. Garg. J. Am. Chem. Soc. 2011, 133, 3832–3835.
    Abstract | PDF | Supporting Information | Synpacts Highlight

                      


  1. 12.Indoles and Indolizidines in Heterocycles in Natural Product Synthesis. Sarah M. Bronner, G-Yoon J.
    Im, and Neil K. Garg; K. C. Majumdar and S. K. Chattopadhyay, Eds.; Wiley–VCH, 2011.


  1. 11.Indolyne Experimental and Computational Studies: Synthetic Applications and Origins of Selectivities of Nucleophilic Additions.
    G-Yoon J. Im, Sarah M. Bronner, Adam E. Goetz, Robert S. Paton, Paul H.-Y. Cheong, K. N. Houk, and Neil K. Garg.
    J. Am. Chem. Soc. 2010, 132, 17933–17944.
    Abstract | PDF | Supporting Information



  1. 7.Indolyne and Aryne Distortions and Nucleophilic Regioselectivities.
    Paul H.-Y. Cheong, Robert S. Paton, Sarah M. Bronner, G-Yoon J. Im, Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc. 2010, 132, 1267–1269.
    Abstract | PDF | Supporting Information | Chemistry World Highlight



  1. 5.Efficient Synthesis of 2-(Trimethylsilyl)phenyl Trifluoromethanesulfonate: A Versatile Precursor to o-Benzyne.
    Sarah M. Bronner and Neil K. Garg. J. Org. Chem. 2009, 74, 8842–8843.
    Abstract | PDF | Supporting Information | ACS Noteworthy Chemistry Highlight



  1. 3.Concise Synthesis of the Bicyclic Scaffold of N-Methylwelwitindolinone C Isothiocyanate via an Indolyne Cyclization.
    Xia Tian, Alexander D. Huters, Colin J. Douglas, and Neil K. Garg. Org. Lett. 2009, 11, 2349–2351.
    Abstract | PDF | Supporting Information



  1. 2.Indolynes as Electrophilic Indole Surrogates: Fundamental Reactivity and Synthetic Applications.
    Sarah M. Bronner, Kevin B. Bahnck, and Neil K. Garg. Org. Lett. 2009, 11, 1007–1010.
    Abstract | PDF | Supporting Information

 

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