RESEARCH INTERESTS Jim Gimzewski's research is deeply connected with convergence and application of nanoscale science and technology with an emphasis on mechanics on the nanoscale. His research encompasses crucial aspects of physics, chemistry, engineering and life sciences, medicine and art. His research consists of: (1) Nanomechanical dynamics and nanoarchitechtonics of living cells. This work is related to cancer, the action of drugs, environmental factors and other mutations in individual cells. The research pioneers the role of mechanics and cellular motion with the aim to develop new forms of medical diagnoses at the single cell level. (2) Use of biochemistry and AFM to gene profile DNA on the single molecule level. (3) Production of compact high energy beams of neutrons, photons, ions, and electrons using point source emitters coupled with piezoelectric and pyroelectric effects. Notable recent developments include the demonstration of thermo-nuclear fusion using a pocket-sized device powered by cooling the device by 20C below ambient. Production of X-rays with fluxes suitable for X-ray radiology have also been demonstrated. (4) More recent work explores recyling of waste energy into electrical power. |
AFM USED TO DIAGNOSE CANCER CELLS
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Above: Immunofluorescence analysis of a clinical pleural effusion displaying two cell populations. Image shows the positive immunofluorescence triple labeling assay for DNA(blue fluorescence), F-actin(green fluorescence), and Ber-EP4(red fluorescence).
Supplemental materials (includes a brief description of cancer cell morphology and how an AFM works). Read the paper on the Nature website.
All content and images © 2007 James K. Gimzewski, UCLA, and/or UC Regents. Use of an content and/or images with written permission only. Please contact gimadmin@chem.ucla.edu for hi-res copies for web and print publication. |
Left to right: Cross, Gimzewski, Rao and Jin. UCLA's Jonsson Comprehensive Cancer Center comprises about 235 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. One of the nation's largest comprehensive cancer centers, the Jonsson center is dedicated to promoting research and translating basic science into leading-edge clinical studies. In July 2007, the Jonsson Cancer Center was named the best cancer center in California by U.S. News & World Report, a ranking it has held for eight consecutive years. For more information on the Jonsson Cancer Center, visit our web site at www.cancer.mednet.ucla.edu. The California NanoSystems Institute is a multidisciplinary research center at UCLA whose mission is to encourage university–industry collaboration and to enable the rapid commercialization of discoveries in nanosystems. CNSI members include some of the world’s preeminent scientists, and the work conducted at the institute represents world-class expertise in five targeted areas of nanosystems-related research: renewable energy, environmental nanotechnology and nanotoxicology, nanobiotechnology and biomaterials, nanomechanical and nanofluidic systems, and nanoelectronics, photonics and architectonics. For additional information, visit www.cnsi.ucla.edu.
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POCKET-SIZED NUCLEAR FUSION
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Experimental vacuum system for crystal fusion.
For more information go to the UCLA Crystal Fusion page. Read the paper and view supplemental materials (including video) on the Nature website.
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SWARMING BACTERIA AT HIGH RESOLUTION
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Atomic Force Microscope image of a group of Myxococcus zanthus bacteria. Each sausage shaped structure is a single bacterium.
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FREIGHT-CARRYING PROTEINS VIBRATE THE WALLS OF CELLS
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Atomic Force Microscope image of yeast cells. The dish shaped structures are "bud scars" created when the cells divide.
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WORLD'S SMALLEST CALCULATOR |
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Series of image of ten C60 molecules arranged latteral, from bottom moving one molecule at a time to count from 0 to 10 in nanometer steps. |
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RESEARCH AT IBM ZURICH
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Low temperature (4K) STM image of a copper surface showing two carbon monoxide molecules and electron standing waves.
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