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The Maynard Group creates new polymeric materials to address unmet needs in medicine, while simultaneously educating the next generation of scientists.

Latest Publication
Therapeutic Protein-Polymer Conjugates: Advancing Beyond PEGylation

Pelegri-O'Day, E. M.; Lin, E.-W.; Maynard, H. D.; "Therapeutic Protein-Polymer Conjugates: Advancing Beyond PEGylation," J. Am. Chem. Soc. 2014, published online. [LINK]

Protein-polymer conjugates are widely used as therapeutics. All Food and Drug Administration (FDA) approved protein conjugates are covalently linked to poly(ethylene glycol) (PEG). These PEGylated drugs have longer half-lives in the blood stream leading to less frequent dosing, a significant advantage for patients. However, there are some potential drawbacks to PEG that are driving the development of alternatives. Polymers that display enhanced pharmacokinetic properties along with additional advantages such as improved stability or degradability will be important to advance the field of protein therapeutics. This perspective presents a summary of protein-PEG conjugates for therapeutic use and alternative technologies in various stages of development, as well as suggestions for future directions. Established methods of producing protein-PEG conjugates and new approaches utilizing controlled radical polymerization are also covered.

 

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Recent News

  • July 2014: Heather listed in C&EN as Who's who (talks to go to) for the San Francisco National Meeting
  • June 2014: Congratulations to recent PhDs Juneyoung Lee and Nic Matsumoto! They will be going on to postdocs with Bob Grubbs at Caltech and Bert Meijer at Eindhoven, respectively
  • June 2014: Erhan's collaborative paper with Imperial College London receives cover of Adv. Funct. Mater
  • April 2014: Heather featured on UCLA OIP [LINK]
  • April 2014: Emma receives NSF Grad Fellowship
  • February 2014: Cait receives Departmental Fellowship
  • November 2013: En-wei wins the 2014 Cram Fellowship
  • November 2013: Heather and Kathy win the Herbert Newby McCoy Award for Outstanding Research at UCLA

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Last Updated: September 19, 2014