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The Maynard Group performs cutting-edge research on polymer bioconjugates and protein nanoarrays and educates the next generation of researchers and leaders in organic chemistry, polymer science, nanotechnology, and biomedicine. Latest Publication Rock J. Mancini, Juneyoung Lee, and Heather D. Maynard In this paper are reported trehalose side chain polymers for stabilization of protein conjugates to environmental stressors. Polymers containing trehalose pendant groups were prepared via reversible addition-fragmentation chain transfer polymerization using thiol-reactive chain transfer agents for subsequent conjugation to proteins through disulfide linkages. The glycopolymers when added or covalently attached to protein significantly increased stability towards lyophilization and heat relative to wild-type protein. The glycopolymers were compared to equivalent concentrations of trehalose and poly(ethylene glycol) and found to be superior. In addition, the protein-glycopolymer conjugates exhibited significant increases in lyophilization stability when compared to adding the same concentration of unconjugated polymer to the protein. The results show that the polymer is promising as a stabilizer of proteins to environmental stressors as an excipient and conjugate.
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