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The Maynard Group creates new polymeric materials to address unmet needs in medicine, while simultaneously educating the next generation of scientists.

 

 

Latest Publication
Imine Hydrogels with Tunable Degradability for Tissue Engineering

Boehnke, N.; Cam, C.; Bat, E.; Segura, T.; Maynard, H. D., "Imine Hydrogels with Tunable Degradabilityfor Tissue Engineering," Biomacromolecules, 2015, DOI: 10.1021/acs.biomac.5b00519. [LINK]

A shortage of available organ donors has created a need for engineered tissues. In this context, polymer-based hydrogels that break down inside the body are often used as constructs for growth factors and cells. In this paper we reported imine cross-linked gels where degradation is controllable by the introduction of mixed imine cross-links. Specifically, hydrazide-functionalized poly(ethylene glycol) (PEG) reacts with aldehyde-functionalized PEG (PEG-CHO) to form hydrazone linked hydrogels that degrade quickly in media. The time to degradation can be controlled by changing the structure of the hydrazide group or by introducing hydroxylamines to form non-reversible oxime linkages. Hydrogels containing adipohydrazide-functionalized PEG (PEG-ADH) and PEG-CHO were found to degrade more rapidly than gels formed from carbodihydrazide-functionalized PEG (PEG-CDH). Incorporating oxime linkages via aminooxy-functionalized PEG (PEG-AO) into the hydrazone cross-linked gels further stabilized the hydrogels. This imine cross-linking approach should be useful for modulating the degradation characteristics of 3D cell culture supports for controlled cell release.

 

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Recent News

  • June 2015: Heather appears in video to let undergraduates know what it is like to be a professor. [LINK]
  • May 2015: Yang finishes her postdoc and moves to be an Assistant Professor at Chapman University
  • May 2015: Heather is selected for the Defense Science Study Group for 2016-2017
  • March 2015: Heather named Associate Director of Technology and Development of the CNSI
  • January 2015:Yuta's paper receives cover of Polymer Chemistry and is selected as paper of the week [LINK]
  • October 2014: Congratulations to recent PhDs, En-Wei Lin and Thi Kathy Nguyen! ¬†They will be going to Nalco as a Principal Chemist and UCLA, respectively
  • September 2014: En-wei and Natalie's paper makes Editor's Choice [LINK]
  • September 2014: Congratulations to Muhammet Kahveci who finished his postdoc and moved to Ylidiz Technical University in Turkey as an Assistant Professor of Bioengineering!

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Last Updated: September 19, 2014