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The Maynard Group creates new polymeric materials to address unmet needs in medicine, while simultaneously educating the next generation of scientists.

 

 

Latest Publication
Dual pH- and Temperature-Responsive Protein Nanoparticles

Matsumoto, N. M.; Buchman, G. W.; Rome, L. H.; Maynard, H. D., "Dual pH- and Temperature-Responsive Protein Nanoparticles," European Polymer Journal, DOI: 10.1016/j.eurpolymj.2015.01.043. [LINK]

Multiply responsive protein nanoparticles are interesting for a variety of applications.  In this paper we describe the synthesis of a vault nanoparticle that responds to both temperature and pH.  Specifically, poly(N-isopropylacrylamide-co­-acrylic acid) with a pyridyl disulfide end group was prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization.  The polymer had a lower critical solution temperature (LCST) of 31.9 °C at pH 5, 44.0 °C at pH 6 and above 60 °C at pH 7.  The polymer was conjugated to human major vault protein (hMVP), and the resulting nanoparticle was analyzed by UV-Vis, dynamic light scattering (DLS) and electron microscopy.  The data demonstrated that poly(N-isopropylacrylamide-co­-acrylic acid)-vault conjugate did not respond to temperatures below 60 °C at pH 7, while the nanoparticles reversibly aggregated at pH 6.  Furthermore, it was shown that the vault nanoparticle structure remained intact for at least three heat and cooling cycles.  These dually responsive nanoparticles may serve as a platform for drug delivery and other applications. 

 

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Recent News

  • March 2015: Heather named Associate Director of Technology and Development of the CNSI
  • January 2015:Yuta's paper receives cover of Polymer Chemistry and is selected as paper of the week [LINK]
  • October 2014: Congratulations to recent PhDs, En-Wei Lin and Thi Kathy Nguyen!  They will be going to Nalco as a Principal Chemist and UCLA, respectively
  • September 2014: En-wei and Natalie's paper makes Editor's Choice [LINK]
  • September 2014: Congratulations to Muhammet Kahveci who finished his postdoc and moved to Ylidiz Technical University in Turkey as an Assistant Professor of Bioengineering!
  • July 2014: Heather listed in C&EN as Who's who (talks to go to) for the San Francisco National Meeting
  • June 2014: Congratulations to recent PhDs Juneyoung Lee and Nic Matsumoto! They will be going on to postdocs with Bob Grubbs at Caltech and Bert Meijer at Eindhoven, respectively

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Last Updated: September 19, 2014