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The Maynard Group creates new polymeric materials to address unmet needs in medicine, while simultaneously educating the next generation of scientists.

 

 

Latest Publication
Trehalose glycopolymer resists allow direct writing of protein patterns by electron-beam lithography

Bat, E.; Lee, J.; Lau, U. Y.; Maynard, H. D., "Trehalose glycopolymer resists allow direct writing of protein patterns by electron-beam lithography," Nature Communications, DOI:10.1038/ncomms7654. [LINK]

Direct-write patterning of multiple proteins on surfaces is of tremendous interest for a myriad of applications. Precise arrangement of different proteins at increasingly smaller dimensions is a fundamental challenge to apply the materials in tissue engineering, diagnostics, proteomics and biosensors. Herein, we present a new resist that protects proteins during electron-beam exposure and its application in direct-write patterning of multiple proteins. Polymers with pendant trehalose units are shown to effectively crosslink to surfaces as negative resists, while at the same time providing stabilization to proteins during the vacuum and electron-beam irradiation steps. In this manner, arbitrary patterns of several different classes of proteins such as enzymes, growth factors and immunoglobulins are realized. Utilizing the high-precision alignment capability of electron-beam lithography, surfaces with complex patterns of multiple proteins are successfully generated at the micrometre and nanometre scale without requiring cleanroom conditions.

 

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Recent News

  • March 2015: Heather named Associate Director of Technology and Development of the CNSI
  • January 2015:Yuta's paper receives cover of Polymer Chemistry and is selected as paper of the week [LINK]
  • October 2014: Congratulations to recent PhDs, En-Wei Lin and Thi Kathy Nguyen! ¬†They will be going to Nalco as a Principal Chemist and UCLA, respectively
  • September 2014: En-wei and Natalie's paper makes Editor's Choice [LINK]
  • September 2014: Congratulations to Muhammet Kahveci who finished his postdoc and moved to Ylidiz Technical University in Turkey as an Assistant Professor of Bioengineering!
  • July 2014: Heather listed in C&EN as Who's who (talks to go to) for the San Francisco National Meeting
  • June 2014: Congratulations to recent PhDs Juneyoung Lee and Nic Matsumoto! They will be going on to postdocs with Bob Grubbs at Caltech and Bert Meijer at Eindhoven, respectively

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Last Updated: September 19, 2014