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The Maynard Group creates new polymeric materials to address unmet needs in medicine, while simultaneously educating the next generation of scientists.

 

 

Latest Publication
Amphiphilic/Fluorous Random Copolymers as a New Class of Biocompatible Polyeric Materials for Protein Conjugation

Koda, Y.; Terashima, T.*; Sawamoto, M.; Maynard, H. D., “Amphiphilic/Fluorous Random Copolymers as a New Class of Biocompatible Polymeric Materials for Protein Conjugation,”Polymer Chemistry2014, DOI:  .10.1039/C4PY01346H [LINK]

In this paper, amphiphilic/fluorous random copolymers bearing poly(ethylene glycol) (PEG) chains and perfluorinated alkane pendants were developed as novel biocompatible polymers for protein conjugation.  Three kinds of random copolymers with different initiating terminals (carboxylic acid, pyridyl disulfide, N-hydroxysuccinimide ester) were prepared by reversible addition-fragmentation chain transfer (RAFT) copolymerization of a PEG methyl ether methacrylate and a perfluorinated alkane methacrylate with corresponding functional chain transfer agents.  All of the polymers were soluble in water to form nanostructures with perfluorinated compartments via fluorous interaction: large aggregates from the intermolecular multi-chain association and compact unimer micelles from the intramolecular single-chain folding.  Such a PEGylated and perfluorinated random copolymer was non-cytotoxic to NIH 3T3 mouse embryonic fibroblast cells and human umbilical vein endothelial cells (HUVECs).  Additionally, a random copolymer with a pyridyl disulfide terminal was also successfully conjugated with a thiolated lysozyme.  This paper describes a new polymer for protein conjugate that could have far reaching applications in the biomedical field.  

 

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Recent News

  • October 2014: Congratulations to recent PhDs, En-Wei Lin and Thi Kathy Nguyen!  They will be going to Nalco as a Principal Chemist and UCLA, respectively
  • September 2014: En-wei and Natalie's paper makes Editor's Choice [LINK]
  • September 2014: Congratulations to Muhammet Kahveci who finished his postdoc and moved to Ylidiz Technical University in Turkey as an Assistant Professor of Bioengineering!
  • July 2014: Heather listed in C&EN as Who's who (talks to go to) for the San Francisco National Meeting
  • June 2014: Congratulations to recent PhDs Juneyoung Lee and Nic Matsumoto! They will be going on to postdocs with Bob Grubbs at Caltech and Bert Meijer at Eindhoven, respectively
  • June 2014: Erhan's collaborative paper with Imperial College London receives cover of Adv. Funct. Mater
  • April 2014: Heather featured on UCLA OIP [LINK]

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Last Updated: September 19, 2014