The Maynard Research Group

Publications

Heredia, K. L.; Nguyen, T. H.; Chang, C. -W.; Bulmus, V.; Davis, T. P.; Maynard, H. D., "Reversible siRNA-Polymer Conjugates by RAFT Polymerization," Chem. Commun., 2008, 28, 3245-3247.

Tolstyka, Z. P.; Kopping, J. T.; Maynard, H. D., "Straightforward Synthesis of Cysteine-Reactive Telechelic Polystyrene," Macromolecules, 2008, 41, 599-606.

Broyer, R. M.; Quaker, G. M.; Maynard, H. D., "Designed Amino Acid ATRP Initiators for the Synthesis of Biohybrid Materials," J. Am. Chem. Soc., 2008, 130, 1041-1047.

Kopping, J. T.; Tolstyka, Z. P.; Maynard, H. D., "Telechelic Aminooxy-Polystyrene Synthesized by ATRP and ATR Coupling," Macromolecules, 2007, 40, 8593-8599.

Maynard, H. D.; Heredia, K. L.; Li, R. C.; Parra, D. P.; Vazquez-Dorbatt, V., "Thermoresponsive Biohybrid Materials Synthesized by ATRP," J. Mater. Chem., 2007, 17, 4015-4017. (invited for special theme issue on Biomaterials)

Mendes, P. M.; Christman, K. L.; Parthasarathy, P.; Schopf, E.; Ouyang, J.; Yang, Y.; Preece, J. A.; Maynard, H. D.; Chen, Y.; Stoddart, J. F., "Electrochemically Controllable Conjugation of Proteins on Surfaces," Bioconjugate Chem., 2007, 18, 1919-1923.

Wong, T. S.; Brough, B.; Christman, K. L.; Kolodziej, C. M.; Huang, A.; Lam, R.; Forbes, J. G.; Wang, K.; Maynard, H. D.; Ho, C. M., "Manufacture of Nanoscale Structures through Top-down and Bottom-up Approaches," IEEE Review on Advances in Micro, Nano and Molecular Systems, 2007, in press.

Li, R. C.; Hwang, J.; Maynard, H.D., "Reactive Block Copolymer Scaffolds," Chem. Commun., 2007, 3631-3633. (and cover of that issue)

Hwang, J.; Li, R. C.; Maynard, H. D., "Well-Defined Polymers with Activated Ester and Protected Aldehyde Side Chains for Bio-functionalization," J. Controlled Release, 2007, 122, 279-286.

Heredia, K. L.; Tolstyka, Z. P.; Maynard, H. D., "Aminooxy End-Functionalized Polymers Synthesized by ATRP for Chemoselective Conjugation to Proteins," Macromolecules, 2007, 40, 4772-4779.

Christman, K. L.; Broyer, R. M.; Tolstyka, Z. P.; Maynard, H. D., "Site-Specific Protein Immobilization through N-Terminal Oxime Linkages," J. Materials Chemistry, 2007, 17, 2021-2027. (invited for Emerging Investigators Issue)

Brough, B.; Christman, K. L.; Wong, T. S.; Kolodziej, C. M.; Forbest, J. G.; Wang, K.; Maynard, H. D.; Ho, C. M, "Surface Initiated Actin Polymerization from Top-down Manufactured Nanopatterns," Soft Matter, 2007, 3, 541-546. (and cover of that issue)

Heredia, K. L.; Maynard, H. D., "Synthesis of Protein-Polymer Conjugates," Organic & Biomolecular Chemistry, 2007, 5, 45-53. (and cover of that issue)

Christman, K. L.; Enriquez-Rios, V. D.; Maynard, H. D., "Nanopatterning Proteins and Peptides," Soft Matter, 2006, 2, 928-939.

Vazquez-Dorbatt, V.; Maynard H. D., "Biotinylated Glycopolymers Synthesized by Atom Transfer Radical Polymerization," Biomacromolecules, 2006, 7, 2297-2302.

Christman, K. L.; Requa, M. V.; Enriquez-Rios, V. D.; Ward, S. C.; Bradley, K. A.; Turner, K. L.; Maynard, H. D., "Submicron Streptavidin Patterns for Protein Assembly," Langmuir, 2006, 22, 7444-7450.

Li, R. C,; Broyer, R. M.; Maynard, H. D., "Well-Defined Polymers with Acetal Side Chains as Reactive Scaffolds Synthesized by Atom Transfer Radical Polymerization," J. Polym. Sci., Part A: Polym. Chem., 2006, 44, 5004-5013.

Heredia, K. L.; Bontempo, D.; Ly, T.; Byers, J. T.; Halstenberg, S.; Maynard, H. D.,"In-Situ Preparation of Protein-"Smart" Polymer Conjugates with Retention of Bioactivity, " J. Am. Chem. Soc., 2005, 127, 16955-16960.

Bontempo, D.; Li, R. C.; Ly, T.; Brubaker, C. E.; Maynard, H. D., "One-Step Synthesis of Low Polydispersity, Biotinylated Poly(N-Isopropylacrylamide) by ATRP," Chem. Commun., 2005, 37, 4702-4704.

Christman, K. L.; Maynard, H. D., "Protein Micropatterns Using a pH-Responsive Polymer and Light," Langmuir, 2005, 21, 8389-8393.

Bontempo, D.; Maynard, H. D.,"Streptavidin as a Macroinitiator for Polymerization: In Situ Protein-Polymer Conjugate Formation" J. Am. Chem. Soc., 2005, 127, 6508-6509.

Maynard, H. D.; Hubbell, J. A., "Discovery of a Sulfated Tetrapeptide that Binds to Vascular Endothelial Growth Factor" Acta Biomaterialia, 2005, 1, 451-459.

Bontempo, D.; Heredia, K. L.; Fish, B. A.; Maynard, H. D., "Cysteine-Reactive Polymers Synthesized by Atom Transfer Radical Polymerization for Conjugation to Proteins," J. Am. Chem. Soc., 2004, 126, 15372-15373.

Maynard, H. D.; Lyu, S.; Fredrickson, G. H.; Wudl, F.; Chmelka, B. F., "Syntheses of Nanophase-Segregated Poly(vinyl acetate)-Poly(dimethylsiloxane) and Poly(vinyl acetate)-Poly(styrene) Graft Copolymers," Polymer, 2001, 42, 7567-7574.

Maynard, H. D.; Okada, S. Y.; Grubbs, R. H., "Inhibition of Cell Adhesion to Fibronectin by Oligopeptide-Substituted Polynorbornenes," J. Am. Chem. Soc., 2001, 123, 1275-1279.

Maynard, H. D.; Okada, S. Y.; Grubbs, R. H., "Synthesis of Norbornenyl Polymers With Bioactive Oligopeptides by Ring-Opening Metathesis Polymerization," Macromolecules, 2000, 33, 6239-6248.

Maynard, H. D.; Grubbs, R. H., "Synthesis of Functionalized Polyethers by Ring-Opening Metathesis Polymerization of Unsaturated Crown Ethers," Macromolecules, 1999, 32, 6917-6924.

Maynard, H. D.; Grubbs, R. H., "Purification Technique for the Removal of Ruthenium from Olefin Metathesis Reaction Products," Tetrahedron Lett., 1999, 40, 4137-4140.

Williams, S. R.; Maynard, H. D.; Chmelka, B. F., "Synthesis of 13C-Enriched Pyrrole from 2-13C D-Galactose," J. Labelled Cpd. Radiopharm., 1999, 42, 927-936.

Marsella, M. J.; Maynard, H. D.; Grubbs, R. H., "Template-Directed Ring-Closing Metathesis: Synthesis and Polymerization of Unsaturated Crown Ether Analogs," Angew. Chem., Int. Ed. Engl., 1997, 36, 1101-1103.

Wagener, K. B.; Patton, J. T.; Forbes, M. D. E.; Myers, T. L.; Maynard, H. D., "Acyclic Diene Metathesis Polymerization: The Synthesis of Unsaturated Polyketones," Polym. Intern., 1993, 32, 411-415.

Forbes, M. D. E.; Patton, J. T.; Myers, T. L.; Maynard, H. D.; Smith, D. W.; Schulz, G. R.; Wagener, K. B., "Solvent-Free Cyclization of Linear Dienes Using Olefin Metathesis and the Thorpe-Ingold Effect," J. Am. Chem. Soc., 1992, 114, 10978-10980.

Forbes, M. D. E.; Myers, T. L.; Dukes, K. E.; Maynard, H. D., "Biradicals and Spin-Correlated Radical Pairs Anchored to SiO2 Surfaces: Probing Diffusion at the Solid/Solution Interface,"
J. Am. Chem. Soc., 1992, 114, 353-354.

Forbes, M. D. E.; Dukes, K. E.; Myers, T. L.; Maynard, H. D.; Breivogel, C. S.; Jaspan, H. B., "Time-Resolved Electron Paramagnetic Resonance Spectroscopy of Organic Free Radicals Anchored to SiO2 Surfaces," J. Phys. Chem., 1991, 95, 10547-10549.

Maynard, M. S.; Maynard, H. D., "HPLC Assay for Avermectin B1a and its Two Photoisomers Using a Photo Diode Array Detector," Bull. Environ. Contam. Toxicol., 1989, 43, 499-504.

Conferences Publications

Hwang, J.; Maynard, H. D., "Multi-Functional Polymers Prepared by RAFT," Polym. Prepr., 2004, 45(1), 1083-1084.

Bontempo, D; Maynard, H. D., "Protein Macroinitiators for Atom Transfer Radical Polymerization," Polym. Prep., 2005, 46(1), 78-79.

Heredia, K. L.; Maynard, H. D., "Aminooxy-Functionalized Semitelechelic Polymers Synthesized by Atom Transfer Radical Polymerization," Polym. Prepr., 2005, 46(1), 593-594.

Christman, K. L.; Maynard, H. D., "Protein Patterning on Polymer Films Using Localized Acid Generation," Polym. Prepr., 2005, 46(2), 1286.

Bontempo, D.; Li, R. C.; Maynard, H. D., "Synthesis of Biotinylated Polymers by Atom Transfer Radical Polymerization and Bioconjugate Formation," Polym. Prepr., 2005, 46(2), 435-436.

Christman, K. L.; Requa, M. V.; Enriquez-Rios, V. D.; Mendes, P.; Stoddart, J. S.; Turner, K. L.; Maynard, H. D., "Sub-Micron Patterning on Polymer Films for Protein Arrays," in Nanoparticles and Nanostructures in Sensors and Catalysis, edited by Chuan-Jian Zhong, Nicholas A. Kotov, Wayne Daniell, Francis P. Zamborini (Mater. Res. Soc. Symp. Proc. 900E, Warrendale, PA, 2005), paper # 0900-O09-35

Christman, K. L.; Requa, M. V.; Enriquez-Rios, V. D.; Ward, S. C.; Bradley, K. A.; Turner, K. L.; Maynard, H. D., "Nanopatterned Polymer Films for Bioconjugation," Polym. Mater. Sci. Eng., 2006, 94, 31.

Li, R. C.; Maynard, H. D., "ATRP of 3,3'-Diethoxypropyl Methacrylate," Polym. Mater. Sci. Eng., 2006, 94, 363.

Vázquez-Dorbatt, V.; Maynard, H. D., "Biotinylated Glycopolymers by Atom Transfer Radical Polymerization," Polym. Mater. Sci. Eng., 2006, 94, 362.

Broyer, R. M.; Li, R. C.; Maynard, H. D., "Conjugation of an Oligo(Ethylene Glycol) to a Reactive Polymer Scaffold," Polym. Mater. Sci. Eng., 2006, 94, 364.

Heredia, K. L.; Maynard, H. D., "In-Situ Preparation of Bovine Serum Albumin-Poly(PEG Methacrylate) Conjugates," Polym. Mater. Sci. Eng., 2006, 94, 354.

Li, R. C.; Hwang, J.; Maynard, H. D., "Reactive Block Copolymer Scaffolds Prepared by RAFT Polymerization," Polym. Mater. Sci. Eng., 2007, 96, 339.

Heredia, K. L.; Tolstyka, Z. P.; Maynard, H. D., "Aminooxy Functionalized Polymers by ATRP for Chemoselective Conjugation to Proteins," Polym. Mater. Sci. Eng., 2007, 96, 346.

Broyer, R. M.; Maynard, H. D., "Well-Defined Glycopolymers Synthesized from an ATRP Amino Acid Initiator," Polym. Mater. Sci. Eng., 2007, 96, 358.

Maynard, H. D.; Christman, K. L.; Broyer, R. M.; Tolstyka, Z. P.; Schopf, E.; Kolodziej, C. M.; Chen, Y., "Protein Patterns at the Micro- and Nanoscale by Oxime Bond Formation," Proceedings of the Society for Biomaterials, 2007, 32, 278.

Christman, K. L.; Brough, B.; Wong, T. S.; Kolodziej, C. M.; Forbes, J. G.; Wang, K.; Ho, C. M.; Maynard, H. D., "Modified Multi-Arm Poly(Ethylene Glycol) Nanopatterns for Unidirectional Actin Polymerization," Proceedings of the Society for Biomaterials, 2007, 32, 705.

Wong, T. S.; Brough, B.; Christman, K. L.; Kolodziej, C. M.; Huang, A.; Lam, R.; Forbes, J. G.; Wang, K.; Maynard, H. D.; Ho, C. M., "Engineered Synthesis of Natural Structures through Guided Bottom-up Assembly," Proceedings of the 7th IEEE international Conference on Nanotechnology, 2007, in press.

Heredia, K. L.; Grover, G.; Maynard, H. D., "In-Situ RAFT Polymerization," Polym. Prepr., 2007, 48, 1039.

Tao, L.; Maynard, H. D., "Telechelic Poly(NIPAAm) by RAFT Polymerization," Polym. Mater. Sci. Eng., 2007, 97, 711.

Broyer, R. M.; Christman, K. L.; Tolstyka, Z. P.; Maynard, H. D., "Synthesis of Polymers for Micro- and Nanopatterning of Oriented Proteins," Polym. Mater. Sci. Eng., 2007, 97, 479-480.

Vazquez-Dorbatt, V.; Maynard, H. D., "Synthesis of Aminooxy End-Functionalized Polymers by RAFT Polymerization for Bioconjugate Formation," Polym. Mater. Sci. Eng., 2007, 97, 724.

Tolstyka, Z. P.; Kopping, J. T.; Maynard, H. D., "Telechelic polystyrene for bioconjugation," Polym. Mater. Sci. Eng., 2008, 98 610.

Grover, G.; Heredia, K. L.; Tao, L.; Maynard, H. D., "Synthesis of hetero-telechelic "smart" polymers by RAFT polymerization," Polym. Mater. Sci. Eng., 2008, 98 469.

Patents

Grubbs, R. H.; Marsella, M. J.; Maynard, H. D., "Template-Directed Ring-Closing Metathesis and Ring-Opening Metathesis Polymerization of Functionalized Dienes," U.S. Patent # 6,080,826, June 27, 2000.

Grubbs, R. H.; Maynard, H. D.; Lynn, D. M., "Method of Removing Transition Metals," U.S. Patent # 6,376,690, April 23, 2002.

Hubbell, J. A.; Schoenmakers, R.; Maynard, H. D., "Compositions and Methods for Use of Bioactive Agents Derived from Sulfated and Sulfonated Amino Acids," U.S. Patent # 7060681, June 13, 2006.

Maynard, H. D.; Bontempo, D., "Biomacromolecule Polymer Conjugates," U.S. Patent Application #10/576,038, Filed April 14, 2006.

Non-Scientific Press

UCLA Cancer Discoveries: 2004-2005: "Junior Faculty: Joining the Fight Against Cancer"

UCLA College Report, Spring-Summer 2004: "It's a Small, Small World"

UCLA Magazine, Summer 2003: http://www.magazine.ucla.edu/year2003/summer03_03_03.html

UCLA Dept. of Chemistry and Biochemistry Alumni Newsletter: http://www.chem.ucla.edu/~alice/ALUM_NEWSLTR/SP04_pg2.html