The Maynard Group

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 Publications

 

 

Stuckel, J. M.; Li, R. C.; Maynard, H. D.; Caplan, M. R., “Two-step Synthesis of Multivalent Cancer-Targeting Constructs,” Biomacromolecules, in press.

Alconcel, S. N. S.; Grover, G. N.; Matsumoto, N. M.; Maynard, H. D., “Synthesis of Michael Acceptor Ionomers of Poly(4-Sulfonated Styrene-co-Poly(Ethylene Glycol) Methyl Ether Acrylate),” Australian Journal of Chemistry, in press.

Heredia, K. L.; Tao, L.; Grover, G. N.; Maynard, H. D., “Heterotelechelic Polymers for Capture and Release of Protein-Polymer Conjugates,” submitted for publication.

Vázquez-Dorbatt, V.; Tolstyka, Z. P.; Maynard, H. D., “Synthesis of Aminooxy End-functionalized pNIPAAm by RAFT Polymerization for Protein and Polysaccharide Conjugation,” Macromolecules, 2009, 42, 7650–7656.

Grover, G. N.; Alconcel, S. N. S.; Matsumoto, N. M.; Maynard, H. D., Synthesis of Thiol Terminated Acrylate Polymers with Divinyl Sulfone to Generate Well-Defined Semi-Telechelic Michael Acceptor Polymers,” Macromolecules, 2009, 42 , 7657–7663.

Mancini, R. J.; Li, R. C.; Tolstyka, Z. P.; Maynard, H. D., “Synthesis of a Photo-caged Aminooxy Alkane Thiol,” Org. Biomol. Chem., published online, DOI: 10.1039/b904195h.

Vázquez-Dorbatt, V.; Tolstyka, Z. P.; Chang, C. W.; Maynard, H. D., “Synthesis and Application of a Pyridyl Disulfide End-Functionalized Glycopolymer,” Biomacromolecules, 2009, 10, 2207-2212.

Tao, L.; Kaddis, C. S.; Ogorzalek Loo, R. R.; Grover, G. N.; Loo, J. A.; Maynard, H. D., “Synthesis of Maleimide-End Functionalized Star Polymers and Multimeric Protein-Polymer Conjugates,” Macromolecules, 2009, 42, 8028–8033.

Schopf, E.; Broyer, R. M.; Tao, L.; Chen, Y.; Maynard, H. D., Directed Carbon Nanotube Assembly Using a Pyrene Functionalized Polymer,” Chem. Commun., 2009, 4818-4820.

Bays, E.; Tao, L.; Chang, C. W.; Maynard, H. D., “Synthesis of Semi-telechelic Maleimide Poly(PEGA) for Protein Conjugation by RAFT Polymerization,” Biomacromolecules, 2009, 10, 1777-1781.

Chang, C. W.; Bays, E.; Tao, L.; Alconcel, S. A.; Maynard, H. D., “Differences in Cytotoxicity of Poly(PEGA)s Synthesized by Reversible Addition-Fragmentation Chain Transfer Polymerization,” Chem. Commun., 2009, 3580-3582.

Tao, L; Kaddis, C. S.; Ogorzalek Loo, R. R.; Grover, G.N.; Loo, J. A.; Maynard, H. D., “Synthetic Approach to Homodimeric Protein-Polymer Conjugates,” Chem. Commun., 2009, 2148 – 2150.

Heredia, K. L.; Grover, G. N.; Tao, L.; Maynard, H. D., “Synthesis of Heterotelechelic Polymers for Conjugation of Two Different Proteins,” Macromolecules, 2009, 42, 2360-2367.

Chosen for cover of that issue, Highlighted on the American Chemical Society Main Webpage.

Christman, K. L.; Schopf, E.; Broyer, R. M.; Li, R. C.; Chen, Y.; Maynard, H. D., “Positioning Multiple Proteins at the Nanoscale with Electron Beam Cross-Linked Functional Polymers,” J. Am. Chem. Soc., 2009, 131, 521-527.

Christman, K. L.; Vázquez-Dorbatt, V.; Schopf, E.; Kolodziej, C. M.; Li, R. C.; Broyer, R. M.; Chen, Y.; Maynard, H. D., “Nanoscale Growth Factor Patterns by Immobilization on a Heparin Mimicking Polymer,” J. Am. Chem. Soc., 2008, 130, 16585-16591.

Heredia, K. L.; Nguyen, T. H.; Chang, C. -W.; Bulmus, V.; Davis, T. P.; Maynard, H. D., "Reversible siRNA-Polymer Conjugates by RAFT Polymerization," Chem. Commun., 2008, 28, 3245-3247.

Tolstyka, Z. P.; Kopping, J. T.; Maynard, H. D., "Straightforward Synthesis of Cysteine-Reactive Telechelic Polystyrene," Macromolecules, 2008, 41, 599-606.

Broyer, R. M.; Quaker, G. M.; Maynard, H. D., "Designed Amino Acid ATRP Initiators for the Synthesis of Biohybrid Materials," J. Am. Chem. Soc., 2008, 130, 1041-1047.

Kopping, J. T.; Tolstyka, Z. P.; Maynard, H. D., "Telechelic Aminooxy-Polystyrene Synthesized by ATRP and ATR Coupling," Macromolecules, 2007, 40, 8593-8599.

Maynard, H. D.; Heredia, K. L.; Li, R. C.; Parra, D. P.; Vazquez-Dorbatt, V., "Thermoresponsive Biohybrid Materials Synthesized by ATRP," J. Mater. Chem., 2007, 17, 4015-4017. (invited for special theme issue on Biomaterials)

Mendes, P. M.; Christman, K. L.; Parthasarathy, P.; Schopf, E.; Ouyang, J.; Yang, Y.; Preece, J. A.; Maynard, H. D.; Chen, Y.; Stoddart, J. F., "Electrochemically Controllable Conjugation of Proteins on Surfaces," Bioconjugate Chem., 2007, 18, 1919-1923.

Wong, T. S.; Brough, B.; Christman, K. L.; Kolodziej, C. M.; Huang, A.; Lam, R.; Forbes, J. G.; Wang, K.; Maynard, H. D.; Ho, C. M., "Manufacture of Nanoscale Structures through Top-down and Bottom-up Approaches," IEEE Review on Advances in Micro, Nano and Molecular Systems, 2007, in press.

Li, R. C.; Hwang, J.; Maynard, H.D., "Reactive Block Copolymer Scaffolds," Chem. Commun., 2007, 3631-3633. (and cover of that issue)

Hwang, J.; Li, R. C.; Maynard, H. D., "Well-Defined Polymers with Activated Ester and Protected Aldehyde Side Chains for Bio-functionalization," J. Controlled Release, 2007, 122, 279-286.

Heredia, K. L.; Tolstyka, Z. P.; Maynard, H. D., "Aminooxy End-Functionalized Polymers Synthesized by ATRP for Chemoselective Conjugation to Proteins," Macromolecules, 2007, 40, 4772-4779.

Christman, K. L.; Broyer, R. M.; Tolstyka, Z. P.; Maynard, H. D., "Site-Specific Protein Immobilization through N-Terminal Oxime Linkages," J. Materials Chemistry, 2007, 17, 2021-2027. (invited for Emerging Investigators Issue)

Brough, B.; Christman, K. L.; Wong, T. S.; Kolodziej, C. M.; Forbest, J. G.; Wang, K.; Maynard, H. D.; Ho, C. M, "Surface Initiated Actin Polymerization from Top-down Manufactured Nanopatterns," Soft Matter, 2007, 3, 541-546. (and cover of that issue)

Heredia, K. L.; Maynard, H. D., "Synthesis of Protein-Polymer Conjugates," Organic & Biomolecular Chemistry, 2007, 5, 45-53. (and cover of that issue)

Christman, K. L.; Enriquez-Rios, V. D.; Maynard, H. D., "Nanopatterning Proteins and Peptides," Soft Matter, 2006, 2, 928-939.

Vazquez-Dorbatt, V.; Maynard H. D., "Biotinylated Glycopolymers Synthesized by Atom Transfer Radical Polymerization," Biomacromolecules, 2006, 7, 2297-2302.

Christman, K. L.; Requa, M. V.; Enriquez-Rios, V. D.; Ward, S. C.; Bradley, K. A.; Turner, K. L.; Maynard, H. D., "Submicron Streptavidin Patterns for Protein Assembly," Langmuir, 2006, 22, 7444-7450.

Li, R. C,; Broyer, R. M.; Maynard, H. D., "Well-Defined Polymers with Acetal Side Chains as Reactive Scaffolds Synthesized by Atom Transfer Radical Polymerization," J. Polym. Sci., Part A: Polym. Chem., 2006, 44, 5004-5013.

Heredia, K. L.; Bontempo, D.; Ly, T.; Byers, J. T.; Halstenberg, S.; Maynard, H. D.,"In-Situ Preparation of Protein-"Smart" Polymer Conjugates with Retention of Bioactivity, " J. Am. Chem. Soc., 2005, 127, 16955-16960.

Bontempo, D.; Li, R. C.; Ly, T.; Brubaker, C. E.; Maynard, H. D., "One-Step Synthesis of Low Polydispersity, Biotinylated Poly(N-Isopropylacrylamide) by ATRP," Chem. Commun., 2005, 37, 4702-4704.

Christman, K. L.; Maynard, H. D., "Protein Micropatterns Using a pH-Responsive Polymer and Light," Langmuir, 2005, 21, 8389-8393.

Bontempo, D.; Maynard, H. D.,"Streptavidin as a Macroinitiator for Polymerization: In Situ Protein-Polymer Conjugate Formation" J. Am. Chem. Soc., 2005, 127, 6508-6509.

Maynard, H. D.; Hubbell, J. A., "Discovery of a Sulfated Tetrapeptide that Binds to Vascular Endothelial Growth Factor" Acta Biomaterialia, 2005, 1, 451-459.

Bontempo, D.; Heredia, K. L.; Fish, B. A.; Maynard, H. D., "Cysteine-Reactive Polymers Synthesized by Atom Transfer Radical Polymerization for Conjugation to Proteins," J. Am. Chem. Soc., 2004, 126, 15372-15373.

Maynard, H. D.; Lyu, S.; Fredrickson, G. H.; Wudl, F.; Chmelka, B. F., "Syntheses of Nanophase-Segregated Poly(vinyl acetate)-Poly(dimethylsiloxane) and Poly(vinyl acetate)-Poly(styrene) Graft Copolymers," Polymer, 2001, 42, 7567-7574.

Maynard, H. D.; Okada, S. Y.; Grubbs, R. H., "Inhibition of Cell Adhesion to Fibronectin by Oligopeptide-Substituted Polynorbornenes," J. Am. Chem. Soc., 2001, 123, 1275-1279.

Maynard, H. D.; Okada, S. Y.; Grubbs, R. H., "Synthesis of Norbornenyl Polymers With Bioactive Oligopeptides by Ring-Opening Metathesis Polymerization," Macromolecules, 2000, 33, 6239-6248.

Maynard, H. D.; Grubbs, R. H., "Synthesis of Functionalized Polyethers by Ring-Opening Metathesis Polymerization of Unsaturated Crown Ethers," Macromolecules, 1999, 32, 6917-6924.

Maynard, H. D.; Grubbs, R. H., "Purification Technique for the Removal of Ruthenium from Olefin Metathesis Reaction Products," Tetrahedron Lett., 1999, 40, 4137-4140.

Williams, S. R.; Maynard, H. D.; Chmelka, B. F., "Synthesis of 13C-Enriched Pyrrole from 2-13C D-Galactose," J. Labelled Cpd. Radiopharm., 1999, 42, 927-936.

Marsella, M. J.; Maynard, H. D.; Grubbs, R. H., "Template-Directed Ring-Closing Metathesis: Synthesis and Polymerization of Unsaturated Crown Ether Analogs," Angew. Chem., Int. Ed. Engl., 1997, 36, 1101-1103.

Wagener, K. B.; Patton, J. T.; Forbes, M. D. E.; Myers, T. L.; Maynard, H. D., "Acyclic Diene Metathesis Polymerization: The Synthesis of Unsaturated Polyketones," Polym. Intern., 1993, 32, 411-415.

Forbes, M. D. E.; Patton, J. T.; Myers, T. L.; Maynard, H. D.; Smith, D. W.; Schulz, G. R.; Wagener, K. B., "Solvent-Free Cyclization of Linear Dienes Using Olefin Metathesis and the Thorpe-Ingold Effect," J. Am. Chem. Soc., 1992, 114, 10978-10980.

Forbes, M. D. E.; Myers, T. L.; Dukes, K. E.; Maynard, H. D., "Biradicals and Spin-Correlated Radical Pairs Anchored to SiO2 Surfaces: Probing Diffusion at the Solid/Solution Interface,"
J. Am. Chem. Soc., 1992, 114, 353-354.

Forbes, M. D. E.; Dukes, K. E.; Myers, T. L.; Maynard, H. D.; Breivogel, C. S.; Jaspan, H. B., "Time-Resolved Electron Paramagnetic Resonance Spectroscopy of Organic Free Radicals Anchored to SiO2 Surfaces," J. Phys. Chem., 1991, 95, 10547-10549.

Maynard, M. S.; Maynard, H. D., "HPLC Assay for Avermectin B1a and its Two Photoisomers Using a Photo Diode Array Detector," Bull. Environ. Contam. Toxicol., 1989, 43, 499-504.

 

Book Chapters

Garrell, R. G.; Maynard, H. D. "Surface Molecular Property Control" in Biomedical Technology: Applications to Microfluidics, Nano Optics and Surface Chemistry, Edited by C. M. Ho, Oxford University Press: Oxford, in press.

Christman, K. L.; Maynard, H. D. "Surface Patterning for Generating Defined Nanoscale Matrices" in Methods in Molecular Biology: Stem Cells for Myocardial Repair and Regeneration, Edited by R. Lee, Humana Press, Inc., Totowa, NJ, in press.

Maynard, H. D.; Broyer, R. M.; Kolodziej, C. M. "Protein and Peptide Conjugation to Polymers and Surfaces Using Oxime Chemistry," in Click Chemistry for Biotechnology and Materials Science, Edited by J. Lahann, Wiley Inc., in press.

 

Conferences Publications

Hwang, J.; Maynard, H. D., "Multi-Functional Polymers Prepared by RAFT," Polym. Prepr., 2004, 45(1), 1083-1084.

Bontempo, D; Maynard, H. D., "Protein Macroinitiators for Atom Transfer Radical Polymerization," Polym. Prep., 2005, 46(1), 78-79.

Heredia, K. L.; Maynard, H. D., "Aminooxy-Functionalized Semitelechelic Polymers Synthesized by Atom Transfer Radical Polymerization," Polym. Prepr., 2005, 46(1), 593-594.

Christman, K. L.; Maynard, H. D., "Protein Patterning on Polymer Films Using Localized Acid Generation," Polym. Prepr., 2005, 46(2), 1286.

Bontempo, D.; Li, R. C.; Maynard, H. D., "Synthesis of Biotinylated Polymers by Atom Transfer Radical Polymerization and Bioconjugate Formation," Polym. Prepr., 2005, 46(2), 435-436.

Christman, K. L.; Requa, M. V.; Enriquez-Rios, V. D.; Mendes, P.; Stoddart, J. S.; Turner, K. L.; Maynard, H. D., "Sub-Micron Patterning on Polymer Films for Protein Arrays," in Nanoparticles and Nanostructures in Sensors and Catalysis, edited by Chuan-Jian Zhong, Nicholas A. Kotov, Wayne Daniell, Francis P. Zamborini (Mater. Res. Soc. Symp. Proc. 900E, Warrendale, PA, 2005), paper # 0900-O09-35

Christman, K. L.; Requa, M. V.; Enriquez-Rios, V. D.; Ward, S. C.; Bradley, K. A.; Turner, K. L.; Maynard, H. D., "Nanopatterned Polymer Films for Bioconjugation," Polym. Mater. Sci. Eng., 2006, 94, 31.

Li, R. C.; Maynard, H. D., "ATRP of 3,3'-Diethoxypropyl Methacrylate," Polym. Mater. Sci. Eng., 2006, 94, 363.

Vázquez-Dorbatt, V.; Maynard, H. D., "Biotinylated Glycopolymers by Atom Transfer Radical Polymerization," Polym. Mater. Sci. Eng., 2006, 94, 362.

Broyer, R. M.; Li, R. C.; Maynard, H. D., "Conjugation of an Oligo(Ethylene Glycol) to a Reactive Polymer Scaffold," Polym. Mater. Sci. Eng., 2006, 94, 364.

Heredia, K. L.; Maynard, H. D., "In-Situ Preparation of Bovine Serum Albumin-Poly(PEG Methacrylate) Conjugates," Polym. Mater. Sci. Eng., 2006, 94, 354.

Li, R. C.; Hwang, J.; Maynard, H. D., "Reactive Block Copolymer Scaffolds Prepared by RAFT Polymerization," Polym. Mater. Sci. Eng., 2007, 96, 339.

Heredia, K. L.; Tolstyka, Z. P.; Maynard, H. D., "Aminooxy Functionalized Polymers by ATRP for Chemoselective Conjugation to Proteins," Polym. Mater. Sci. Eng., 2007, 96, 346.

Broyer, R. M.; Maynard, H. D., "Well-Defined Glycopolymers Synthesized from an ATRP Amino Acid Initiator," Polym. Mater. Sci. Eng., 2007, 96, 358.

Maynard, H. D.; Christman, K. L.; Broyer, R. M.; Tolstyka, Z. P.; Schopf, E.; Kolodziej, C. M.; Chen, Y., "Protein Patterns at the Micro- and Nanoscale by Oxime Bond Formation," Proceedings of the Society for Biomaterials, 2007, 32, 278.

Christman, K. L.; Brough, B.; Wong, T. S.; Kolodziej, C. M.; Forbes, J. G.; Wang, K.; Ho, C. M.; Maynard, H. D., "Modified Multi-Arm Poly(Ethylene Glycol) Nanopatterns for Unidirectional Actin Polymerization," Proceedings of the Society for Biomaterials, 2007, 32, 705.

Wong, T. S.; Brough, B.; Christman, K. L.; Kolodziej, C. M.; Huang, A.; Lam, R.; Forbes, J. G.; Wang, K.; Maynard, H. D.; Ho, C. M., "Engineered Synthesis of Natural Structures through Guided Bottom-up Assembly," Proceedings of the 7th IEEE international Conference on Nanotechnology, 2007, in press.

Heredia, K. L.; Grover, G.; Maynard, H. D., "In-Situ RAFT Polymerization," Polym. Prepr., 2007, 48, 1039.

Tao, L.; Maynard, H. D., "Telechelic Poly(NIPAAm) by RAFT Polymerization," Polym. Mater. Sci. Eng., 2007, 97, 711.

Broyer, R. M.; Christman, K. L.; Tolstyka, Z. P.; Maynard, H. D., "Synthesis of Polymers for Micro- and Nanopatterning of Oriented Proteins," Polym. Mater. Sci. Eng., 2007, 97, 479-480.

Vazquez-Dorbatt, V.; Maynard, H. D., "Synthesis of Aminooxy End-Functionalized Polymers by RAFT Polymerization for Bioconjugate Formation," Polym. Mater. Sci. Eng., 2007, 97, 724.

Tolstyka, Z. P.; Kopping, J. T.; Maynard, H. D., "Telechelic polystyrene for bioconjugation," Polym. Mater. Sci. Eng., 2008, 98 610.

Grover, G.; Heredia, K. L.; Tao, L.; Maynard, H. D., "Synthesis of hetero-telechelic "smart" polymers by RAFT polymerization," Polym. Mater. Sci. Eng., 2008, 98 469.

Maynard, H. D.; Vazquez-Dorbatt, V.; Christman, K. L., "Synthesis of End-Functionalized Glycopolymers by CRP for Surface Patterning," Polym. Prepr., 2008, 49 (2), 318.

Vazquez-Dorbatt, V.; Maynard, H. D., "Synthesis of Thiol-Reactive Glycopolymers by ATRP," Polym. Prepr., 2008, 49 (2), 610.

Patents

Grubbs, R. H.; Marsella, M. J.; Maynard, H. D., "Template-Directed Ring-Closing Metathesis and Ring-Opening Metathesis Polymerization of Functionalized Dienes," U.S. Patent # 6,080,826, June 27, 2000.

Grubbs, R. H.; Maynard, H. D.; Lynn, D. M., "Method of Removing Transition Metals," U.S. Patent # 6,376,690, April 23, 2002.

Hubbell, J. A.; Schoenmakers, R.; Maynard, H. D., "Compositions and Methods for Use of Bioactive Agents Derived from Sulfated and Sulfonated Amino Acids," U.S. Patent # 7060681, June 13, 2006.

Maynard, H. D.; Bontempo, D., "Biomacromolecule Polymer Conjugates," U.S. Patent Application #10/576,038, Filed April 14, 2006.

 

Non-Scientific Press

UCLA Cancer Discoveries: 2004-2005: "Junior Faculty: Joining the Fight Against Cancer"

UCLA College Report, Spring-Summer 2004: "It's a Small, Small World"

UCLA Magazine, Summer 2003: http://www.magazine.ucla.edu/year2003/summer03_03_03.html

UCLA Dept. of Chemistry and Biochemistry Alumni Newsletter: http://www.chem.ucla.edu/~alice/ALUM_NEWSLTR/SP04_pg2.html

 
  

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Last Updated: 1 July 2009