Ferritin in Chlamydomonas reinhardtii

Ferritin is a key enzyme in maintaining iron homeostasis. In vertebrates, it is a multimetric protein consisting of both heavy (H, 21 kDa) and light (L, 19 kDa) subunits with iron stored as ferric oxyhydroxide Fe(III)OOH. In plants, however, there is only one protein which is most closely related to the H subunit but has similarities to the L subunit. The pre-protein has a plastid specific N-terminus sequence that targets the protein to the chloroplasts, proplastids, etioplasts, chromoplasts, and amyloplasts. Ferritin consists of 24 subunits arranged in compact shape of 4.3.2 symmetry. In A. thaliana there are multiple ferritin genes, but the following sequence probably represents a single ferritin gene in C. reinhardtii.

-56       ATGCATACGAGGTCTAGAATTTCGGGCGCTTGGCGTTGTCCTTACCAAGTCACGTA
+1    ATGGCGCTCTGTGCTCGCGTTTTCGGGGCCCCGGCCAAGCTGGCGAAGCAGCAGGTGGTT
      M  A  L  C  A  R  V  F  G  A  P  A  K  L  A  K  Q  Q  V  V
+61   ACCCCCCGGCGCACTTCGGCCCCTCGCGCTGTGGCGCGCCATGCCACTGTGGACAAGATC
      T  P  R  R  T  S  A  P  R  A  V  A  R  H  A  T  V  D  K  I
+121  ACTGGCATTGTTGTTCAGCCTGCCGTTCAGTTCTCGGAGGTGCAGAGCGAGCTGGCGACC
      T  G  I  V  V  Q  P  A  V  Q  F  S  E  V  Q  S  E  L  A  T
+181  GTGGATAAGACCAACCAGAACATCCAGTCGCTGGCGCGCGTTGACTTCCACCCAGCCTGC
      V  D  K  T  N  Q  N  I  Q  S  L  A  R  V  D  F  H  P  A  C
+241  GAGGCCGCCATCAACGAGCAGGTCAACATCGAGTACAACGTGTCTTACCTGTACCACGCG
      E  A  A  I  N  E  Q  V  N  I  E  Y  N  V  S  Y  L  Y  H  A
+301  CTGTGGGCCTACTTCGACCGCGACAACGTGGCGCTGCCCGGCCTGGCCGCCTTCTTCAAG
      L  W  A  Y  F  D  R  D  N  V  A  L  P  G  L  A  A  F  F  K
+361  GCCGGCAGCGAGGAGGAGCGCGAGCACGCAGAGCTGCTCATGGAGTACCAGAACCGTCGC
      A  G  S  E  E  E  R  E  H  A  E  L  L  M  E  Y  Q  N  R  R
+421  GGCGGCCGCGTTGTGCTGGGCGCCATCTCCATGCCGGACCTGGACCTCAGCGCCAGCGAG
      G  G  R  V  V  L  G  A  I  S  M  P  D  L  D  L  S  A  S  E
+481  AAGGGCGATGCGCTGTACGCCATGGAGCTGGCCCTGAGCCTGGAGAAGCTCAACTTCCAG
      K  G  D  A  L  Y  A  M  E  L  A  L  S  L  E  K  L  N  F  Q
+541  AAGCTGCGCCAGCTGCACTCGGTGGCGGACGAGCACGGCGATGCCTCCATGGCCGACTTC
      K  L  R  Q  L  H  S  V  A  D  E  H  G  D  A  S  M  A  D  F
+601  GTGGAGGGCGAGCTGCTGAACGAGCAGTTGAGGCTGTGAAGAAGGTGTCCGAGTACGTGT
      V  E  G  E  L  L  N  E  Q  L  R  L  *
+661  CGCAGCTGCGGCGGGTGGGCCAGGGCCTGGGCGTGTACCAGTTTGACAAGCAGCTGGCCG
+721  CCGAGGTGGCCGCCGGCGCCGCCGCGTAAAGGGAGTGGTCGCGTAGCGAGCAGACAGCTC
+781  GGTTGGTTGAGATGGGGGTGAAGAACATGTGAGGGCACAGCTCAGCATGTGATTCTGCGG
+841  GGGGCCATGCAACTCGGCAGTTGATCTTGTAGATTGCGAAGGCGTAGCGTATATGTTGTG
+901  ATCAATTGCAAAGTGTGTGTGGGCATGGCCTTGAAGTAGAATGTGCTTTCTCCTTCCCGT
+961  CGGCGGAGGACTGATCGTGCGCGCGAGGTTGTTTCGCTCGTGCTTCTGATTGTGCACATG
+1021 AGTAACAGGGGTGGAACGGGAGTGTTTCGTGTCGGCATTCGACCTGAAGCACGGCCCCTG
+1081 GACCATACGCGTGACCTGCCGGACCATGACAGGACGCCAAGGGCCGAGTACGCATGCAGT
+1141 GCTTTTTTTGGGTGGCGATGGGTGGCAACGGATAGGATGCTCTTAAATGTGGCGAGAGGA
+1201 GGTGATATGCGATGCAGTCTGGGTGCGCCCTGCGCGGGGTGTATCAGGGGAGGTATCCTC
+1261 GCGGCTACCAGAGCACTTCCCTGCGCTGATCTGTGAATTCCGGGAGGGACCCCAGCGCCC
+1321 TCCCAACCCATGTAAGAAGATCATGCGTCCAAAAAA