(b. 1926), B.Sc. 1949, M.Sc. 1950, University of Sydney; Ph.D. 1952, Oxford University.
Current research includes stereochemistry and NMR spectroscopy. Isotope effects on chemical shifts, particularly those of a conformational (equilibrium) origin are under investigation.
Compound I has been synthesized and shows observably diastereotopic protons in the monodeuterated methyl group. This work has led to an NMR method for directly determining the configuration of a CHDT group by means of tritium NMR. Thus, the tritium NMR chemical shifts in II and III are observably different.
The conformations of cyclic molecules are being studied experimentally by NMR and theoretically by molecular mechanics and ab initio quantum mechanical methods.
Representative Publications
(1) F. A. L. Anet, "Conformational Analysis of Medium Ring Oxygen Heterocycles", in "Conformational Analysis of Medium Sized Ring Heterocycles", S. R. Glass, ed.,VCH Publishers, New York, pp 35-95 (1988).
(2) F. A. L. Anet, "The Conformational Analysis of Cyclohexenes," in "The Conformational Analysis of Cyclohexenes, Cyclohexadienes and Related Hydroaromatic Compounds," P. Rabideau, Ed., VCH Publishers, New York, pp 1-42 (1989).
(3) F. A. L. Anet and M. Kopelevich, " Detection and Assignments of Diastereotopic Chemical Shifts in Partially Deuteriated Methyl Groups of a Chiral Molecule," J. Am. Chem. Soc., 111, 3429 (1989).
(4) F. A. L. Anet and D. J. O'Leary, "The Conformational Preference (A value) of Deuterium in Monodeuteriocyclohexane from Deuteron Integration," Tetrahedron Lett., 30, 1059 (1989).
(5) F. A. L. Anet and D. J. O'Leary, "H-D Coupling Constants and Deuterium Isotope Effects on the Proton Chemical Shifts in Partially Deuteriated Methanes" Tetrahedron Lett., 30, 2755 (1989).
(6) F. A. L. Anet, R. Anet, M. P. Trova, and L. A. Paquette, "Dynamics of Seven- and Eight-membered 1,5-Cycloalkane-Fused Semibullvalene Derivatives," Tetrahedron Lett., 30, 6469 (1989).
(7) F. A. L. Anet, D. J. O'Leary, J. M. Beale, and H. G. Floss, "Stereogenic (Chiral) Methyl Groups: Determination of Configuration by Direct Tritium NMR Spectroscopy," J. Am. Chem. Soc., 111, 8935 (1989).
(8) F. A. L. Anet and D. J. O'Leary, "NMR Line Shapes Caused by Transverse Cross Relaxation of Nearly Like Spins," J. Magn. Reson., 86, 358 (1990).
(9) F. A. L. Anet, "A General Definition of Axial, Equatorial and Related Terms for Substituents on Rings of any Size," Tetrahedron Lett., 31, 2125 (1990).
(10) F. A. L. Anet, D. J. O'Leary, C. G. Wade, and R. D. Johnson, " NMR Relaxation by the Antisymmetric Component of the Shielding Tensor: A Longer Transverse than Longitudinal Relaxation Time," Chem. Phys. Lett., 171, 401 (1990).
(11) F. A. L. Anet, "Inflection Points and Chaotic Behavior in Searching the Conformational Space of Cyclononane," J. Am. Chem. Soc., 112, 7172 (1990).
(12) F. A. L. Anet, D. J. O'Leary, and P. G. Williams, "Tritium NMR in Conformational Analysis: Isotopic Perturbation of the Ring Inversion Equilibrium in [3H]-Cyclohexane," J. Chem. Soc., Chem. Commun., 1427 (1990).
(13) F. A. L. Anet and D. J. O'Leary, "The Shielding Tensor, Part I: Understanding its Symmetry Properties," Concepts in Magn. Reson. 3, 193 (1991).
(14) F. A. L. Anet and D. J. O'Leary, "The Shielding Tensor, Part II: Understanding its Strange Effects on Relaxation," Concepts in Magn. Reson. 4, 35 (1992).
(15) F. A. L. Anet and J. Park, "Proton Chemical Shift Assignments in Citrate and Trimethyl Citrate in Chiral Media," J. Am. Chem. Soc., 114, 411 (1992).
(16) F. A. L. Anet, D. I. Freedberg, J. W. Storer, and K. H. Houk, "On the Potential Energy Surface for Ring Inversion in Cyclohexene and Related Molecules," J. Am. Chem. Soc., 114, 10969 (1992).
(17) F. A. L. Anet and D. I. Freedberg, "Traditional Averaging of NMR Parameters in the Fast Exchange Limit is Valid!," Chem. Phys. Lett. 208, 187 (1993).