Illustrated Glossary of Organic Chemistry
Chichibabin reaction:
A
substitution reaction
in which an
amide anion
(
-
NH
2
) attacks carbon 2 or carbon 4 of a
pyridine ring
, and
hydride ion
(H
-
) is the
leaving group
. Occurs via the
nucleophilic aromatic substitution
reaction mechanism
(the
S
N
Ar mechanism
).
Chichibabin
reaction mechanism
Related terms:
Nitranion
,
electrophilic aromatic substitution
,
name reaction
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