CV
Contact Details:
Sarah Elizabeth Cross
Pico Lab (Gimzewski Lab)
Department of Chemistry and Biochemistry
University of California, Los Angeles
607 Charles E. Young Dr. East
Room #B112
Los Angeles, CA
90095, USA
Phone: +1(310)206-8259
Research Interests:
Nanoscale properties of living biological systems, cell nanomechanics, biophysics, atomic force microscopy (AFM), fluorescence microscopy, confocal microscopy and white light interference microscopy (WLIM).
Application of novel techniques to nano-medicine and -dentistry.
Career Details:
2004-Present Graduate Research Scientist
Professor James K. Gimzewski's Lab,
Chemistry and Biochemistry Department,
UCLA, placeCityLos Angeles, StateCA
2003 - 2004 Laboratory Technician
GRT Inc. (Gas Reaction Technologies Inc.)
UCSB, placeCitySanta Barbara, StateCA
2002 - 2004 Undergraduate Research Assistant
Professor Steve K. Buratto's Lab
Chemistry and Biochemistry Department
UCSB, placeCitySanta Barbara, StateCA
2000 - 2004 B.S. Chemistry (with Honors)
UCSB, placeCitySanta Barbara, StateCA
Current Projects:
Cellular nanomechanics measured by atomic force microscopy as markers for malignancy in patient body fluid samples. (Collaboration with Dr. JianYu Rao and Dr. Yu-Sheng Jin, Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA, USA.)
The effect of green tea extract (GTE) on human lung adenocarcinoma cellular nanomechanics. (Collaboration with Dr. JianYu Rao, Dr. Qing-Yi Lu and Dr. Mai Brooks, Departments of Pathology and Laboratory Medicine, Center for Human Nutrition and Surgery, University of California at Los Angeles, Los Angeles, CA, USA).
Structural analysis of the physical features responsible for the observed optical properties inherent to Morpho peleides butterfly wings: A nanoscale analysis of some of nature's photonic structures using atomic force microscopy. (Collaboration with FEI and Richard Stringer).
Analysis of substrate effects on the culture and function of hepatocyte cells. (Collaboration with placeCityCorning).
Analysis of cell surface adhesion and nanomechanical properties of living Streptococcus mutans wild type and wapA mutant cells using in vivo force spectroscopy. (Collaboration with Dr. Wenyuan Shi, Dr. Fengxia Qi, Dr. Jens Kreth and Lin Zhu, School of Dentistry and Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA, USA).
Quantitative analysis of the effect of sucrose on Streptococcus mutans wild type and mutant cells using atomic force microscopy (AFM). (Collaboration with Dr. Wenyuan Shi, Dr. Fengxia Qi and Dr. Jens Kreth, School of Dentistry and Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA, USA).
Nanomechanical motion of the cell wall of Saccharomyces cerevisiae. (Collaboration with Dr. Joan Valentine, Dr. Edith Gralla and Sadaf Sehati, Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA, USA).
Analysis of hydroxyapatite using white light interference microscopy (WLIM). (Collaboration with Dr. Richard Sullivan, Colgate-Palmolive Company: Nanotechnology Research for Oral Care).
Publications:
“Nanomechanics of Human Metastatic Cancer Cells in Clinical Pleural Effusions,” S.E. Cross, Y. Jin, J. Rao and J.K. Gimzewski. Submitted, Nature Nanotechnology (July 2007).
“Biofilm Erosion of Tooth Enamel Measured Using Optical Profilometry,” S.E. Cross J. Kreth, W. Shi and J. K. Gimzewski. In Progress.
“Nanomechanical Properties of Glucans and Associated Cell-Surface Adhesion and Dynamics of Streptococcus mutans Probed by Atomic Force Microscopy under in vivo Conditions,” S. E. Cross, J. Kreth, L. Zhu, W. Shi, F. Qi and J. K. Gimzewski. Accepted Microbiology (April, 2007).
“Self-Organized and Highly Ordered Domain Structures within Swarms of Myxococcus Xanthus,” A. E. Pelling, L. Yinuo, S. E. Cross, S. Castaneda, W. Shi and J. K. Gimzewski. Cell Motility and the Cytoskeleton, 63, 141-148 (2006).
“Functional Characterization of Cell Wall-Associated Protein WapA in Streptococcus mutans,” L. Zhu, J. Kreth, S. E. Cross, J. K. Gimzewski, W. Shi and F. Qi. Microbiology, 152, 2395-2404 (2006).
“Atomic Force Microscopy Study of the Structure-Function Relationships of the Biofilm-Forming Bacterium Streptococcus mutans,” S. E. Cross, J. Kreth, L. Zhu, F. Qi, A. E. Pelling, W. Shi and J. K. Gimzewski. Nanotechnology, 17, S1-S7 (2006).
“Surface-Enhanced Raman Scattering from Ordered Ag Nanocluster Arrays,” J. P. Schmidt, S. E. Cross and S. K. Buratto. J. Chem. Phys., 121, 10657-10659 (2004).
Selected Talks:
Sarah E. Cross, Yu-Sheng Jin, JianYu Rao and James K. Gimzewski. “Atomic Force Microscopy-Based Cytological Analysis: A Novel Platform for Cancer Diagnosis and Chemoprevention .” International Conference on Materials for Advanced Technologies - ICMAT and GEM4 Conference on Cancer, 2007. Singapore. July 1 - 6, 2007.
Sarah E. Cross, Yu-Sheng Jin, JianYu Rao and James K. Gimzewski. “Application of Atomic Force Microscopy-Based Cytological Analysis: A Novel Technique Platform for Cancer Diagnosis and Evaluation.” Seeing at the Nanoscale V. Santa Barbara, CA, USA. June 24 - 27, 2007.
Sarah E. Cross and James K. Gimzewski. “Application of AFM to Nano-Medicine and -Dentistry: A Nanomechanical Analysis of Biological Systems,” Integration of Nanostructures/NanoSystems Into Micro/Macro Platforms, The ERI NINT/NRC/Canada-California Initiative, CNSI. UCLA, Thomas Bradley International Hall, March 8-9, 2007 (Invited).
Sarah E. Cross, Jens Kreth, Lin Zhu, Fengxia Qi, Wenyuan Shi and James K. Gimzewski. “Cell-Cell and Cell-Surface Interactions: Nanomechanics of Single Streptococcus mutans Cells and their Biofilms.” 2006 SCCAVS Symposium: The Leading Edge Student Symposium. Anaheim, CA. October 3, 2006.
Sarah E. Cross, Jens Kreth, Lin Zhu, Fengxia Qi, Wenyuan Shi, Qing-Yi Lu, JianYu Rao and James K. Gimzewski. “Applications of Nano-Medicine and -Dentistry: Nanomechanics and Architectonics of Human Lung Adenocarcinoma Cells and Streptococcus mutans Bacteria.” The 16th International Microscopy Conference (IMC16). Sapporo, Japan. September 3 - 8, 2006.
S. Cross, Q. Lu, J. Rao and J. Gimzewski. “The Effect of Green Tea Extract on the Nanomechanics and Architectonics of Human Lung Adenocarcinoma Cells.” International Conference on Nanoscience and Technology (ICN&T). Basel, Switzerland. July 30 - August 4, 2006.
Cross, S.E., Kreth, J., Qi, F., Shi, W. and Gimzewski, J.K. “Structure-Function Relationships of the Biofilm-Forming Bacterium Streptococcus mutans.” The International Conference on Bio-Nano-Informatics (BNI) Fusion, Marina Del Ray Marriott, Los Angeles, CA, USA. July 20-22, 2005.
Selected Poster Presentations:
Sarah E. Cross, Yu-Sheng Jin, JianYu Rao and James K. Gimzewski. “Nanomechanical-Based Functional Analysis: An Additional Platform for the Cytomorphological Analysis for Cancer Diagnosis in the Future.” NSTI Nanotech Conference. Santa Clara, CA, USA. May 20 - 24, 2007.
Sarah E. Cross, Qing-Yi Lu, Yu-Sheng Jin, JianYu Rao and James K. Gimzewski. “Nanomechanical Responses of Green Tea Extract Induced Annexin-I Expression on Actin Regulation in Human Lung and Prostate Adenocarcinoma Cells in vivo.” AFM BioMed Conference. Barcelona, Spain. April 19 - 21, 2007.
Cross, S.E., Kreth, J., Zhu, L., Qi, F., Shi, W. and Gimzewski, J.K. “Nanoscale Characterization of Living Streptococcus mutans Cell Surface Morphology and Adhesion Using Atomic Force Microscopy.” CNSI 2nd Annual Frontiers in Nanosystems. Sheraton Kauai Resort, Kauai, Hawaii. February 21-24, 2006.
Recent Conferences Attended:
International Conference on Materials for Advanced Technologies - ICMAT and GEM4 Conference on Cancer, 2007. Singapore. July 1 - 6, 2007.
Seeing at the Nanoscale V. Santa Barbara, CA, USA. June 24 - 27, 2007.
NSTI Nanotech Conference. Santa Clara, CA, USA. May 20 - 24, 2007.
AFM BioMed Conference. Barcelona, Spain. April 19 - 21, 2007.
PITTCON Conference. Chicago, IL. February 25 - 28, 2007.
SCCAVS Symposium: The Leading Edge Student Symposium. Anaheim, CA. October 3, 2006.
The 16th International Microscopy Conference (IMC16). Sapporo, Japan. September 3 - 8, 2006.
International Conference on Nanoscience and Technology (ICN&T). Basel, Switzerland. July 30 - August 4, 2006.
CNSI 2nd Annual Frontiers in Nanosystems, Kauai, USA February 2006.
The American Society for Cell Biology 45th Annual Meeting, SF, CA December 2005.
Seeing at the Nanoscale III an International Conference, SB, CA August 2005.
Bio-Nano-Informatics (BNI) Fusion Conference, LA, CA July 2005.
Microscopy and Microanalysis (2003-2004).
Denver X-ray Conference (2000-2005).
Awards:
2006/2007 UCLA Graduate Division Fellowship Support for Academic Achievement
2005/2006 UCLA Graduate Division Fellowship Support for Academic Achievement
2004. UCSB McRary Memorial Chemistry Prize.
Teaching:
2006-2007. Teaching Assistant Councilor (TAC) for the incoming 2006/2007 chemistry and biochemistry graduate student class
2005/2006. Teaching Assistant Councilor (TAC) for the incoming 2005/2006 chemistry and biochemistry graduate student class
2004. Teaching Assistant for CHM14BL: General Chemistry Lab. Taught by Dr. Maher Henary
|