Structural Biology and Proteomics

An integrated group of structural biologists at UCLA aims ultimately to describe life in three dimensions at the atomic level. This mission is inspired by the avalanche of information flowing from genome sequencing projects and is fostered by the UCLA-DOE Laboratory of Structural Biology and Molecular Medicine. On this frontier problem, investigators bring to bear a variety of powerful tools, including crystallography, multidimensional NMR and computational analysis. The highly interdisciplinary research programs offer special opportunities for talented students with diverse scientific backgrounds in molecular biology, chemistry and biochemistry, computing, mathematics and physics.

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Software developed in the Lee laboratory for the analysis of genome sequence data
automatically annotates novel genes to identify likely structural and functional features in the
encoded protein. The program generates displays, such as the one shown here for a rhinovirus
drug target, that combine sequence analysis, structural information and functional annotation.

Supple Electronics

Research into the chemistry and physics of supple electronic materials and devices constitutes a major interdisciplinary theme within the department. Organic, inorganic, physical and theoretical groups within the department, as well as other groups from engineering and physics, are working together to fabricate a broad class of novel electronic devices. These include: self-assembled networks of molecular switches and resonant tunneling diodes integrated with quantum wires; organic-derived photonic devices such as photovoltaics and light-emitting diodes; and acoustically modulated optical switching crossbars built from quantum dot superstructures. Other related areas of research include photonic band gap materials, switches based on magnetoresistive elements and single electron charging devices.

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A Langmuir monolayer of silver quantum dots that is undergoing
an  acoustically generated, reversible metal/insulator transition.
This technology, which is being developed in the Heath
and Levine laboratories, may be used to fabricate vastly
improved optical switching networks.
(C.P. Collier, S. Henrichs and J. Heath;
image by the UCLA Visualization Lab.)

 

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Extremely short (100 femtosecond) infrared laser pulses are frequecy doubled in a nonlinear optical crystal in the Schwartz
laboratory to produce visible pulses for use in experiments exploring the photophysics of semiconducting polymers.

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