Illustrated Glossary of Organic Chemistry

Heck reaction: A substitution reaction involving an aryl, benzylic, or vinylic halide or triflate and an alkene having at least one vinylic hydrogen, resulting in substitution of the vinylic hydrogen for the group that has the halide or triflate. Requires a Pd0 catalyst and a base.


Vinyl iodide
Methyl methacrylate
A 1,3-diene
In this example Heck reaction, vinyl iodide reacts with methyl methacrylate (an α,β-unsaturated ester) in the presence of Pd(PPh3)4 (a Pd0 catalyst) and K2CO3 (a mild base). The product is a 1,3-diene.