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Diversity Oriented Synthesis (DOS) |
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The third area of our group research entails diversity-oriented combinatorial synthesis (DOS) of libraries of small organic molecules and their applications in chemical genetics. In the chemical genetics approach small molecules are systematically screened for the desired biological effects. Thus, identified small molecules are used to modulate the cellular functions of their target proteins, thereby elucidating the molecular mechanism of biologically important processes. When the protein of interest is a cause for a human disease, the hit from the screening in biological assays may also find its use in therapeutic remedies. Our collaboration with biologists in our chemical genetic research resulted in the discovery of several enzyme inhibitors, on one of which we have filed a patent for the development of anti-cancer therapeutics. Our DOS research program was recently featured in a FiT newsletter. Read the story at the link below: Link Our boss was
profiled in the UCLAINVENTS, a new report
I. Development of New Synthetic Methods II. Target Oriented Synthesis (TOS) of Natural Products
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