172. Evaluation of Retro-Aldol vs Retro-Carbonyl-Ene Mechanistic Pathways in a Complexity Generating C–C Bond Fragmentation

Ana S. Bulger, Daniel W. Turner, Qingyang Zhou, K. N. Houk, Neil K. Garg. Org. Lett. 2024, Manuscript Accepted.



171. Small Molecule Inhibition of RNA Binding Proteins in Haematologic Cancer

Amit K. Jaiswal, Michelle L. Thaxton, Georgia M. Scherer, Jacob P. Sorrentino, Neil K. Garg and Dinesh S. Rao. RNA Biology 2024, 21, 1–14.



164. Electrochemical Oxidation of Δ9-Tetrahydrocannabinol at Nanomolar Concentrations

Christina R. Forbes, Katie A. Spence, Neil K. Garg, and Evan R. Darzi. J. Org. Chem. 2023, 88, 11358–11362.


163. Facile Synthesis of 2-Aza-9,10-diphenylanthracene and the Effect of Precise Nitrogen Atom Incorporation on OLED Emitters Performance

Evan R. Darzi, Dane A. Stanfield, Luca McDermott, Andrew V. Kelleghan, Benjamin J. Schwartz, and Neil K. Garg. Mater. Adv. 2023, 4, 3351–3355.


160. Elucidating the Molecular Programming of a Nonlinear Non-Ribosomal Peptide Synthetase Responsible For Fungal Siderophore Biosynthesis

Matthew Jenner, Yang Hai, Hong H. Nguyen, Munro Passmore, Will Skyrud, Junyong Kim, Neil K. Garg, Wenjun Zhang, Rachel R. Ogorzalek Loo, and Yi Tang. Nat. Commun. 2023, 14, 2832–2843.


155. A Cannabinoid Fuel Cell Capable of Producing Current by Oxidizing Δ9-Tetrahydrocannabinol

Di Huang, Christina R. Forbes, Neil K. Garg, and Evan R. Darzi. Org. Lett. 2022, 24, 6705–6710.

153. Mentoring is More Important than Ever

Jennifer M. Heemstra and Neil K. Garg. Nature Reviews Chemistry 2022, in press.

152. Education Surges When Students Learn Together

Neil K. Garg and Kevin D. Dougherty. Inside Higher Ed 2022, published online May 25, 2022.

142. Cell-Free Total Biosynthesis of Plant Terpene Natural Products using an Orthogonal Cofactor Regeneration System

Undramaa Bat-Erdene, John M. Billingsley, William C. Turner, Benjamin R. Lichman, Francesca M. Ippoliti, Neil K. Garg, Sarah E. O’Connor, and Yi Tang. ACS Catal. 2021, 11, 9898–9903.

141. Cycloaddition Cascades of Strained Alkynes and Oxadiazinones

Melissa Ramirez, † Evan Darzi, † Joyann Donaldson, Kendall N. Houk, Neil K. Garg. Angew. Chem., Int. Ed. 2021, 60, 18201–18208.

136. Origins of Endo Selectivity in Diels–Alder Reactions of Cyclic Allene Dienophiles

Melissa Ramirez, Dennis Svatunek, Fang Liu, Neil K. Garg, and K. N. Houk. Angew. Chem., Int. Ed. 2021, 60, 14989–14997.

134. Taming Radical Pairs in the Crystalline Solid State: Discovery and Total Synthesis of Psychotriadine

Jordan J. Dotson, Ieva Liepuoniute, J. Logan Bachman, Vince M. Hipwell, Saeed I. Khan, K. N. Houk*, Neil K. Garg*, and Miguel A. Garcia-Garibay.* J. Am. Chem. Soc. 2021, 143, 10, 4043–4054.

132. Cyanoamidine Cyclization Approach to Remdesivir’s Nucleobase

Rachel R. Knapp,† Veronica Tona,† Taku Okada, Richmond Sarpong, and Neil K. Garg. Org. Lett. 2020, 22, 8430–8435.

129. An Enzymatic Alder-Ene Reaction

Masao Ohashi, Cooper S. Jamieson, Yujuan Cai, Dan Tan, Daiki Kanayama, Man-Cheng Tang, Sarah M. Anthony, Jason V. Chari, Joyann S. Barber, Elias Picazo, Thomas B. Kakule, Shugeng Cao, Neil K. Garg, Jiahai Zhou, K. N. Houk, and Yi Tang. Nature 2020, 586, 64–69.

128. Intercepting Fleeting Cyclic Allenes with Asymmetric Nickel Catalysis

Michael M. Yamano,† Andrew V. Kelleghan,† Qianzhen Shao,† Maude Giroud, Bryan J. Simmons, Bo Li, Shuming Chen, K. N. Houk, and Neil K. Garg. Nature 2020, 586, 242–247.

126. Putting Mentoring First

Jen Heemstra and Neil Garg. Chemical & Engineering News 2020, 98, (https://cen.acs.org/careers/employment/Putting-mentoring-first/98/i35).

125. Treating a Global Health Crisis with a Dose of Synthetic Chemistry

Melissa A. Hardy, Brandon A. Wright, J. Logan Bachman, Timothy B. Boit, Hannah M. S. Haley, Rachel R. Knapp, Robert F. Lusi, Taku Okada, Veronica Tona, Neil K. Garg*, and Richmond Sarpong.* ACS Cent. Sci. 2020, 6, 1017–1030.

124. Discovery and Total Synthesis of a Bis(Cyclotryptamine) Alkaloid Bearing the Elusive Piperidinoindoline Scaffold

Jordan J. Dotson, J. Logan Bachman, Miguel A. Garcia-Garibay, Neil K. Garg. J. Am. Chem. Soc. 2020, 142, 11685–11690.

122. Evaluation of the photodecarbonylation of crystalline ketones for the installation of reverse prenyl groups on the pyrrolidinoindoline scaffold

Jordan J. Dotson, Neil K. Garg, and Miguel A. Garcia Garibay. Tetrahedron 2020, 76, 131181.

121. Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s Disease

Tina Bilousova, Bryan J. Simmons, Rachel R. Knapp, Chris J. Elias, Jesus Campagna, Mikhail Melnik, Sujyoti Chandra, Samantha Focht, Chunni Zhu, Kanagasabai Vadivel, Barbara Jagodzinska, Whitaker Cohn, Patricia Spilman, Karen H. Gylys, Neil K. Garg, and Varghese John. ACS Chem. Biol. 2020, 15, 1671–1684.

109. Chemoenzymatic Conversion of Amides to Enantioenriched Alcohols in Aqueous Medium

Jacob E. Dander, Maude Giroud, Sophie Racine, Evan R. Darzi, Oscar Alvizo, David Entwistle, and Neil K. Garg. Communications Chemistry 2019, 2, 82.

107. Thioesterase-Catalyzed Aminoacylation and Thiolation of Polyketides in Fungi

Man-Cheng Tang, Curt R. Fischer, Jason V. Chari, Dan Tan, Sundari Suresh, Angela Chu, Molly Miranda, Justin Smith, Zhuan Zhang, Neil K. Garg, Robert P. St. Onge, and Yi Tang. J. Am. Chem. Soc. 2019, 141, 8198–8206.

101. Synthesis of Fused Indolines by Interrupted Fischer Indolization in a Microfluidic Reactor

Alexander Tuan-Huy Duong, Bryan J. Simmons, Mohammad Parvez Alam, Jesus Campagna, Neil K. Garg, Varghese John. Tetrahedron Lett. 2019, 60, 322–326.

100. Canvass: A Crowd-Sourced, Natural Product Screening Library for Exploring Biological Space

Sara E. Kearney, Gergely Zahoránszky-Kőhalmi, Kyle R. Brimacombe, Mark J. Henderson, Caitlin Lynch, Tongan Zhao, Kanny K. Wan, Zina Itkin, Christopher Dillon, Min Shen, Dorian M. Cheff, Tobie D. Lee, Danielle Bougie, Ken Cheng, Nathan P. Coussens, Dorjbal Dorjsuren, Richard T. Eastman, Ruili Huang, Michael J. Iannotti, Surendra Karavadhi, Carleen Klumpp-Thomas, Jacob S. Roth, Srilatha Sakamuru, Wei Sun, Steven A. Titus, Adam Yasgar, Ya-Qin Zhang, Jinghua Zhao, Rodrigo B. Andrade, M. Kevin Brown, Noah Z. Burns, Jin K. Cha, Emily E. Mevers, Jon Clardy, Jason A. Clement, Peter A. Crooks, Gregory D. Cuny, Jake Ganor, Jesus Moreno, Lucas A. Morrill, Elias Picazo, Robert B. Susick, Neil K. Garg, Brian C. Goess, Robert B. Grossman, Chambers C. Hughes, Jeffrey N. Johnston, Madeleine M. Joullié, A. Douglas Kinghorn, David G.I. Kingston, Michael J. Krische, Ohyun Kwon, Thomas J. Maimone, Susruta Majumdar, Katherine N. Maloney, Enas Mohamed, Brian T. Murphy, Pavel Nagorny, David E. Olson, Larry E. Overman, Lauren E. Brown, John K. Snyder, John A. Porco, Jr., Fatima Rivas, Samir A. Ross, Richmond Sarpong, Indrajeet Sharma, Jared T. Shaw, Zhengren Xu, Ben Shen, Wei Shi, Corey Stephenson, Alyssa L. Verano, Derek S. Tan, Yi Tang, Richard E. Taylor, Regan J. Thomson, David A. Vosburg, Jimmy Wu, William M. Wuest, Armen Zakarian, Yufeng Zhang, Tianjing Ren, Zhong Zuo, James Inglese, Sam Michael, Anton Simeonov, Wei Zheng, Paul Shinn, Ajit Jadhav, Matthew B. Boxer, Matthew D. Hall, Menghang Xia, Rajarshi Guha, and Jason M. Rohde. ACS Central Science 2018, 4, 1727–1741.

99. Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki-Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho Substituted Biaryl Synthesis.

Nitinchandra Dahyabhai Patel, Joshua D. Sieber, Sergei Tcyrulnikov, Bryan J. Simmons, Daniel Rivalti, Krishnaja Duvvuri, Yongda Zhang, Donghong A. Gao, Keith R. Fandrick, Nizar Haddad, Kendricks So Lao, Hari Prasad Reddy Mangunuru, Soumik Biswas, Bo Qu, Nelu Grinberg, Scott Pennino, Heewon Lee, Jinhua J. Song, B. Frank Gupton, Neil K. Garg, Marisa C. Kozlowski, and Chris H. Senanayake. ACS Catal. 20188, 10190–10209.

97. Diels–Alder Cycloadditions of Strained Azacyclic Allenes

Joyann S. Barber,† Michael M. Yamano,† Melissa Ramirez, Evan R. Darzi, Rachel R. Knapp, Fang Liu, K. N. Houk, and Neil K. Garg. Nat. Chem. 201810, 953–960.

96. Synthesis of 8-Hydroxygeraniol

Francesca M. Ippoliti,† Joyann S. Barber,† Yi Tang, and Neil K. Garg. J. Org. Chem. 2018, 83, 11323–11326.

94. Arynes and Cyclic Alkynes as Synthetic Building Blocks for Stereodefined Quaternary Centers

Elias Picazo,† Sarah M. Anthony,† Maude Giroud, Adam Simon, Margeaux A. Miller, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc. 2018140, 7605–7610.

89. Understanding and Interrupting the Fischer Azaindolization Reaction

Bryan J. Simmons, Marie Hoffmann, Pier Alexandre Champagne, Elias Picazo, Katsuya Yamakawa, Lucas A. Morrill, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc. 2017139, 14833–14836.

88. Engineering the Biocatalytic Selectivity of Iridoid Production in Saccharomyces cerevisiae

John M. Billingsley, Anthony B. DeNicola, Joyann S. Barber, Man-Cheng Tang, Joe Horecka, Angela Chu, Neil K. Garg, and Yi Tang. Metab. Eng. 201744, 117–125.

86. Conjugated Trimeric Scaffolds Accessible from Indolyne Cyclotrimerizations: Synthesis, Structures, and Electronic Properties

Janice B. Lin, Tejas K. Shah, Adam E. Goetz, Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc2017139, 10447–10455.

83. Enantioselective Nickel-Catalyzed Mizoroki–Heck Cyclizations to Generate Quaternary Stereocenters

Jean-Nicolas Desrosiers, Jialin Wen, Sergei Tcyrulnikov, Soumik Biswas, Bo Qu, Liana Hie, Dmitry Kurouski, Ling Wu, Nelu Grinberg, Nizar Haddad, Carl A. Busacca, Nathan K. Yee, Jinhua J. Song, Neil K. Garg, Xumu Zhang, Marisa C. Kozlowski, and Chris H. Senanayake. Org. Lett201719, 3338–3341.

82. Kinetic Modeling of the Nickel-Catalyzed Esterification of Amides

Nicholas A. Weires, Daniel D. Caspi, and Neil K. Garg. ACS Catal. 20177, 4381–4385.

79. Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases

Michio Sato, Jacob E. Dander, Chizuru Sato, Yiu-sun Hung, Shu-Shan Gao, Man-Cheng Tang, Leibniz Hang, Jaclyn M. Winter, Neil K. Garg, Kenji Watanabe, and Yi Tang. J. Am. Chem. Soc. 2017139, 5317–5320.

77. Enzyme-Catalyzed Stereoselective Intramolecular Hydroalkoxylation

Shu-Shan Gao, Marc Garcia-Borràs, Joyann S. Barber, Yang Hai, Abing Duan, Neil K. Garg, K. N. Houk, and Yi Tang. J. Am. Chem. Soc. 2017139, 3639–3642.

74. Expanding the ROMP Toolbox: Synthesis of Air-Stable Benzonorbornadiene Polymers by Aryne Chemistry

Jose M. Medina, Jeong Hoon Ko, Heather D. Maynard, and Neil K. Garg. Macromolecules 201750, 580–586.

72. Nickel-Catalyzed Esterification of Aliphatic Amides

Liana Hie,† Emma L. Baker,† Sarah M. Anthony, Jean-Nicolas Desrosiers, Chris Senanayake, and Neil K. Garg. Angew. Chem. Int. Ed. 2016, 55, 15129–15132.

70. Quantification of the Electrophilicity of Benzyne and Related Intermediates

Noah F. Fine Nathel,† Lucas A. Morrill,† Herbert Mayr, and Neil K. Garg. J. Am. Chem. Soc2016138, 10402–10405

69. Construction of Quaternary Stereocenters via Nickel-Catalyzed Heck Cyclizations

Jean-Nicolas Desrosiers, Liana Hie, Soumik Biswas, Olga V. Zatolochnaya, Sonia Rodriguez, Heewon Lee, Nelu Grinberg, Nizar Haddad, Nathan K. Yee, Neil K. Garg, and Chris H. Senanayake. Angew. Chem. Int. Ed201655, 11921–11924

64. P450-Mediated Coupling of Indole Fragments to Forge Communesin and Unnatural Isomers

 Hsiao-Ching Lin, Travis C. McMahon, Ashay Patel, Michael Corsello, Adam Simon, Wei Xu, Muxun Zhao, K. N. Houk, Neil K. Garg, and Yi Tang. J. Am. Chem. Soc2016138, 4002–4005

62. Nitrone Cycloadditions of 1,2-Cyclohexadiene

Joyann S. Barber, Evan D. Styduhar, Hung V. Pham, Travis C. McMahon, K. N. Houk, and Neil K. Garg.  J. Am. Chem. Soc2016138, 2512–2515

60. Nickel-Catalyzed Activation of Acyl C–O Bonds of Methyl Esters

Liana Hie, Noah F. Fine Nathel, Xin Hong, Yun-Fang Yang, K. N. Houk, and Neil K. Garg. Angew. Chem. Int. Ed201655, 2810–2814

58. Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast

Man-Cheng Tang, Hsiao-Ching Lin, Dehai Li, Yi Zou, Jian Li, Wei Xu, Ralph A. Cacho, Maureen E. Hillenmeyer, Neil K. Garg, and Yi Tang. J. Am. Chem. Soc2015137, 13724–13727

57. Conversion of Amides to Esters by the Nickel-Catalysed Activation of Amide C–N Bonds

Liana Hie, Noah F. Fine Nathel, Tejas K. Shah, Emma L. Baker, Xin Hong, Yun-Fang Yang, Peng Liu, K. N. Houk, and Neil K. Garg. Nature 2015524, 79–83

55. Generation and Regioselective Trapping of a 3,4-Piperidyne for the Synthesis of Functionalized Heterocycles

Travis C. McMahon,† Jose M. Medina,† Yun-Fang Yang, Bryan J. Simmons, K. N. Houk, and Neil K. Garg. 
J. Am. Chem. Soc. 2015137, 4082–4085

54. Elucidation of the Concise Biosynthetic Pathway of the Communesin Indole Alkaloids

Hsiao-Ching Lin, Grace Chiou, Yit-Heng Chooi, Travis C. McMahon, Wei Xu, Neil K. Garg, and Yi Tang. 
Angew. Chem. Int. Ed. 201554, 3004–3007. (Selected as a Very Important Paper)

53. Computational Predictions of Substituted Benzyne and Indolyne Regioselectivities

Elias Picazo, K. N. Houk, and Neil K. Garg. Tetrahedron Lett. 201556, 3511–3514. (Special issue for Professor Harry Wasserman)

50. The Role of Aryne Distortions, Steric Effects, and Charges on Regioselectivities in Aryne Reactions

Jose M. Medina,† Joel L. Mackey,† Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc2014136, 15798–15805

48. Cycloadditions of Cyclohexynes and Cyclopentyne

Jose M. Medina,† Travis C. McMahon,† Gonzalo Jiménez-Osés, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc2014136, 14706–14709

37. Expanding the Structural Diversity of Polyketides by Exploring the Cofactor Tolerance of an Inline Methyltransferase Domain

Jaclyn M. Winter, Grace Chiou, Ian R. Bothwell,, Wei Xu, Neil K. Garg, Minkui Luo, and Yi Tang. Org. Lett. 201315, 3774–3777

36. EcdGHK are Three Tailoring Iron Oxygenases for Amino Acid Building Blocks of the Echinocandin Scaffold

Wei Jiang, Ralph A. Cacho, Grace Chiou, Neil K. Garg, Yi Tang, and Christopher T. Walsh. J. Am. Chem. Soc. 2013135, 4457–4466

32. Identification and Characterization of the Chaetoviridin and Chaetomugilin Gene Cluster in Chaetomium globosum Reveal Dual Functions of an Iterative Highly-Reducing Polyketide Synthase

Jaclyn M. Winter, Michio Sato, Satoru Sugimoto, Grace Chiou, Neil K. Garg, Yi Tang, and Kenji Watanabe. 
J. Am. Chem. Soc. 2012134, 17900–17903

30. Steric Effects Compete with Aryne Distortion to Control Regioselectivities of Nucleophilic Additions to 3-Silylarynes

Sarah M. Bronner, Joel L. Mackey, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc. 2012134, 13966–13969

25. An Efficient Computational Model to Predict the Synthetic Utility of Heterocyclic Arynes

Adam E. Goetz, Sarah M. Bronner, Jordan D. Cisneros, Joshua M. Melamed, Robert S. Paton, K. N. Houk, and Neil K. Garg. Angew. Chem. Int. Ed. 201251, 2758–2762

24. Total Synthesis of Oxidized Welwitindolinones and (–)-N-Methylwelwitindolinone C Isonitrile

Kyle W. Quasdorf, Alexander D. Huters, Michael W. Lodewyk, Dean J. Tantillo, and Neil K. Garg. J. Am. Chem. Soc. 2012134, 1396–1399

20. Nickel-Catalyzed Amination of Aryl Carbamates and Sequential Site-Selective Cross-Couplings

Tehetena Mesganaw, Amanda L. Silberstein, Stephen D. Ramgren, Noah F. Fine Nathel, Xin Hong, Peng Liu, and Neil K. Garg. Chem. Sci. 2011, 2, 1766–1771

18. Suzuki–Miyaura Cross-Coupling of Aryl Carbamates and Sulfamates: Experimental and Computational Studies

Kyle W. Quasdorf, Aurora Antoft-Finch, Peng Liu, Amanda L. Silberstein, Anna Komaromi, Tom Blackburn, Stephen D. Ramgren, K. N. Houk, Victor Snieckus, and Neil K. Garg. J. Am. Chem. Soc2011133, 6352–6363

17. Why Do Some Fischer Indolizations Fail?

Nihan Çelebi-Olcüm, Ben W. Boal, Alexander D. Huters, Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc2011133, 5752–5755

15. A Fungal Nonribosomal Peptide Synthetase Module that can Synthesize Thiopyrazines

Kangjian Qiao, Hui Zhou, Wei Xu, Wenjun Zhang, Neil K. Garg, and Yi Tang. Org. Lett. 201113, 1758–1761

13. Nickel-Catalyzed Cross-Couplings Involving Carbon–Oxygen Bonds

Brad M. Rosen, Kyle W. Quasdorf, Daniella A. Wilson, Na Zhang, Ana-Maria Resmerita, Neil K. Garg, and Virgil Percec. Chem. Rev. 2011111, 1346–1416 (invited contribution)

11. Indolyne Experimental and Computational Studies: Synthetic Applications and Origins of Selectivities of Nucleophilic Additions

G-Yoon J. Im, Sarah M. Bronner, Adam E. Goetz, Robert S. Paton, Paul H.-Y. Cheong, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc2010132, 17933–17944

7. Indolyne and Aryne Distortions and Nucleophilic Regioselectivities

Paul H.-Y. Cheong, Robert S. Paton, Sarah M. Bronner, G-Yoon J. Im, Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc. 2010132, 1267–1269.