Sabeeha Merchant

SABEEHA MERCHANT

Professor of Biochemistry and Member, Molecular Biology Institute; BS and PhD, University of Wisconsin-Madison; Post-doctoral Scholar, Harvard University; Searle Scholar; National Institutes of Health Research Career Development Award; UCLA Faculty Career Development Awards;  Guggenheim Foundation Fellow; Charles Albert Shull Award of ASPB; Herbert Newby McCoy Award; AAAS Fellow; ASPB Fellow; NAS Gilbert Morgan Smith Medal; ASPB Charles F. Kettering Award; Humboldt Forschungspreis (Alexander von Humboldt Foundation); Darbaker Prize from the Botanical Society of America; Elected to the U.S. National Academy of Sciences, Elected to the American Academy of Arts and Sciences; External Member, Max Planck Institute - Molecular Plant Physiology

RESEARCH DESCRIPTION     


Dynamics of Fe and Cu metabolism
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Plants require CO2, water, sunlight and a few minerals for growth and survival. Carbon contributes to biomass and sunlight the energy. The mineral requirement includes elements, found only at trace levels, like Fe, Zn, Cu and Mn, that enable the catalysis of an amazing repertoire of reactions, especially in the photosynthetic apparatus where biology’s most powerful oxidants and reductants are found. This structure is rich in metalloproteins and contributes to the high metal quota of some photosynthetic cells. Environmental factors can limit the availability of metals, especially Fe, but also Cu and Zn, and this naturally impacts photosynthetic performance and hence global primary productivity. The Merchant group has discovered mechanisms used by photosynthetic organisms to optimize performance in face of changing metal supply, especially limitation. Reduce, reuse and recycle! For instance, the Cu quota is dramatically reduced (to less than 5% relative to a Cu replete situation) by replacement of the copper-protein plastocyanin in photosynthesis with a functionally equivalent heme-containing cytochrome. This occurs through the action of a copper sensor and a transcription factor that recognizes copper response elements associated with the CYC6 gene. In parallel, plastocyanin is degraded, releasing the Cu cofactor, which is re-used for the biosynthesis of respiratory chain cytochrome oxidase. Similarly, Fe is recycled by degradation of ferredoxin to support the synthesis of an Fe-containing superoxide dismutase. The risk associated with the dynamics of metal ion metabolism is reduced by intracellular storage of these metals in a lysosome-related organelle. In ongoing work, the Merchant laboratory uses elemental and protein mass spectrometry in combination with live cell imaging of metal sensors and classical genetics to discover and dissect the biochemistry of the metal storing compartment.

Supported by NIGMS and DOE
Comparative genomics of algae
The Merchant group is also taking advantage of genome-sequencing based approaches for discovery of new components and functions related to photosynthesis and chloroplast biology. The group has amassed the largest collection of RNA-Seq data for Chlamydomonas and are presently creating co-expression networks with a view to deducing the functions of the many unannotated and uncharacterized proteins encoded in the algal genome. This work complements the prior and ongoing phylogenomics approaches for predicting functions for uncharacterized proteins in the plant lineage. Genomes of extremophile algae, isolated from acid mines or from the Svalbard archipelago, are being sequenced and assembled, with a view to discovering mechanisms for light sensing, photoprotection, CO2 concentration and pyrenoid structure and function.

Supported by DOE
Bioenergy

Rising concerns about energy security and the environmental impacts of fossil fuel dependence has created a resurgence in interest in alternative fuel sources. "Biodiesel Fuel" by Prof. Suzanne Paulson of the UCLA Department of Atmospheric & Oceanic Sciences and the Institute of the Environment examines the different types of biodiesel fuel source material, the resources needed to produce this fuel, climate impacts and future applications. Rising concerns about energy security……future applications. The Merchant laboratory has used systems biology approaches, including metabolomics, proteomics and transcriptomics, to deduce the metabolic pathways and regulatory factors that promote the synthesis of triglycerides in Chlamydomonas.

Supported by DOE


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Positions for Ph.D. students and post-doctoral scholars may be available in late 2016 / early 2017 for all Merchant laboratory projects. Candidates with demonstrated research productivity (publication record) and expertise in genetics or biochemistry are especially encouraged to apply for post-doctoral positions. Ph.D. candidates should apply to one of the following:


PUBLICATIONS

From my Ph.D. thesis research

From my Post-Doctoral Research

92. Merchant, S. (2009) Lawrence Bogorad 1921 - 2003: A Biographical Memoir. National Academy of Sciences.

From my Group 1990-1995

From my Group 1996-2000

From my Group 2001-2005

From my Group 2006-2010

From my Group 2011-Present

103. Gabilly S.T., Kropat J., Karamoko M., Page M.D., Nakamoto S.S., Merchant S.S., Hamel P.P. (2011) A Novel Component of the Disulfide Reducing Pathway Required for Cytochrome c Assembly in Plastids. Genetics 187:793-802.

104. Castruita, M., Casero, D., Karpowicz,S.J., Kropat, J., Vieler, A., Hsieh, S.I., Yan, W., Cokus, S., Loo, J.A., Benning, C., Pellegrini, M., Merchant, S.S. (2011) Systems Biology Approach in Chlamydomonas Reveals Connections between Copper Nutrition and Multiple Metabolic Steps. Plant Cell 23:1273-1292. Supplemental Data. Author Profile. In Brief.

105. Karpowicz, S. J., Prochnik, S. E., Grossman, A. R., Merchant, S. S. (2011) The GreenCut2 Resource, a Phylogenomically Derived Inventory of Proteins Specific to the Plant Lineage. J. Biol. Chem. 286:21427-21439. Supplemental Data.

106. Kropat J., Hong-Hermesdorf A., Casero D., Ent P., Castruita M., Pellegrini M., Merchant, S.S., Malasarn D. (2011) A revised mineral nutrient supplement increases biomass and growth rate in Chlamydomonas reinhardtii. Plant J. 66:770-80.

107. Lopez, D., Casero, D., Cokus, S., Merchant, S.S., Pellegrini, M. (2011) Algal Functional Annotation Tool: a web-based analysis suite to functionally interpret large gene lists using integrated annotation and expression data. BMC Bioinformatics 2011, 12:282. Highly Accessed.

108. Grossman, A.R., Gonzalez-Ballester, D., Bailey, S., Karpowicz, S.J., Merchant, S.S. (2012) Understanding photosynthetic electron transport using Chlamydomonas: The path from classical genetics to high throughput genomics in Advances in Photosynthesis and Respiration (ed. W. Burnap and W. Vermaas), vol. 33, pp. 139-176. 

109. Lee Y.J., Huang X., Kropat J., Henras A., Merchant S.S., Dickson R.C., Chanfreau G.F. (2012) Sphingolipid signaling mediates iron toxicity. Cell Metabol. 16:90-96.  

110. Bernal, M., Casero, D., Singh, V., Wilson, G.T., Grande, A., Yang, H., Connolly, E.L., Huijser, P., Pellegrini, M., Merchant, S.S., Krämer, U. (2012) Transcriptome sequencing identifies SPL7-regulated copper acquisition genes FRO4/FRO5 and the copper dependence of iron homeostasis in Arabidopsis. The Plant Cell 24:738-61. Supplemental Data.

111. Page, M.D., Allen, M.D., Kropat, J., Urzica, E., Karpowicz, S., Hsieh, S.I., Loo, J.A., Merchant, S.S. (2012) Fe sparing and Fe recycling contribute to increased superoxide dismutase capacity in iron-starved Chlamydomonas reinhardtii. The Plant Cell 24:2649-2665. Supplemental Data.

112. Merchant, S.S., Kropat, J., Liu, B., Shaw, J., Warakanont, J. (2012) TAG, You're It! Chlamydomonas as a reference organism for understanding algal triacylglycerol  accumulation. Curr. Opin. Biotechnol. 23:352-363.

113. Fang, W., Si, Y., Douglass, S., Casero, D., Merchant, S.S., Pellegrini, M., Liu, P., Spalding, M.H. (2012) Transcriptome-wide changes in Chlamydomonas reinhardtii gene expression regulated by carbon dioxide and the CO2-concentrating mechanism regulator CIA5/CCM1. The Plant Cell 24:1876-1893.

114. Fischer, B.B., Ledford, H.K., Wakao, S., Huang, S.G., Casero, D., Pellegrini, M., Merchant, S.S., Koller, A., Eggen, R.I.L, Niyogi, K.K. (2012) SINGLET OXYGEN RESISTANT 1 links reactive electrophile signaling to singlet oxygen acclimation in Chlamydomonas reinhardtii. Proc. Natl. Acad. Sci. USA. 109: E1302-1311.  

115. Boyle, N.R., Page, M.D., Liu, B., Blaby, I.K., Casero, D., Kropat, J., Cokus, S., Hong-Hermesdorf, A., Shaw, J., Karpowicz, S.J., Johnson, S., Benning, C., Pellegrini, M., Grossman, A.R., Merchant, S.S. (2012) Three acyltransferases and a nitrogen responsive regulator are implicated in nitrogen starvation-induced triacylglycerol accumulation in Chlamydomonas. J. Biol. Chem. 287: 15811-25.

116. Urzica, E.I., Adler, L.N., Page, M.D., Linster. C.L., Arbing, M., Merchant, S.S., Clarke, S.G. (2012) Impact of Oxidative Stress on Ascorbate Biosynthesis in Chlamydomonas via Regulation of the VTC2 Gene Encoding a GDP-L-galactose Phosphorylase. J. Biol. Chem. 287: 14234-14245. Cover Image.

117. Merchant, S.S., Helmann, J.D. (2012) Elemental economy: microbial strategies for optimizing growth in the face of nutrient limitation. Adv. Microbiol. Physiol. 60: 91-210.

118. Blaby-Haas, C.E., Merchant, S.S. (2012) The ins and outs of algal metal transport. Biochim. Biophys. Acta, 1823:1531–1552.

119. Urzica E.I., Casero D., Yamasaki H., Hsieh S.I., Adler L.N., Karpowicz S.J., Blaby-Haas C.E., Clarke S.G., Loo J.A., Pellegrini M., Merchant S.S. (2012) Systems and Trans-System Level Analysis Identifies Conserved Iron Deficiency Responses in the Plant Lineage. The Plant Cell, 24: 3921-3948. Supplemental Data. In Brief. More Resources.

120. Hsieh S.I., Castruita M., Malasarn D., Urzica E., Erde J., Page M.D., Yamasaki H., Casero D., Pellegrini M., Merchant S.S., Loo J.A. (2012) The Proteome of Copper, Iron, Zinc, and Manganese Micronutrient Deficiency in Chlamydomonas reinhardtii. Mol. Cell. Proteomics, 12: 65-86. Supplemental Data.

122. Wang Q., Fristedt R., Yu X., Chen Z., Liu H., Lee Y., Guo H., Merchant S.S., Lin C. (2012) The γ-Carbonic Anhydrase Subcomplex of Mitochondrial Complex I Is Essential for Development and Important for Photomorphogenesis of Arabidopsis. Plant Physiol. 160:1373-1383.

123. Duanmu, D., Casero, D., Dent, R.M., Gallagher, S., Yang, W., Rockwell, N.C., Martin, S.S., Pellegrini, M., Niyogi, K.K., Merchant, S.S., Grossman, A.R., Lagarias, J.C. (2013) Retrograde bilin signaling enables Chlamydomonas greening and phototrophic survival. Proc Natl Acad Sci U S A. 110:3621-6. Commentary.

124. Hemschemeier, A., Düner, M., Casero, D., Merchant, S.S., Winkler, M., Happe, T. (2013) Hypoxic survival requires a 2-on-2 hemoglobin in a process involving nitric oxide. Proc Natl Acad Sci U S A. 110:10854-9.

125. Hemschemeier, A., Casero, D., Liu, B., Benning, C., Pellegrini, M., Happe, T., Merchant, S.S. (2013) Copper response regulator1-dependent and -independent responses of the Chlamydomonas reinhardtii transcriptome to dark anoxia. Plant Cell. 25(9):3186-211. Supplemental Data.

126. Malasarn, D., Kropat, J., Hsieh. S.I., Finazzi, G., Casero, D., Loo, J.A., Pellegrini, M., Wollman, F.A., Merchant, S.S. (2013) Zinc deficiency impacts CO2 assimilation and disrupts copper homeostasis in Chlamydomonas reinhardtii. J. Biol. Chem. 288:10672-83. Supplemental Data.

127. Ming, R., Vanburen, R., Liu, Y., Yang, M., Han, Y., Li, L.-T., Zhang, Q., Kim, M.-J., Schatz, M.C., Campbell, M., Li, J., Bowers, J.E., Tang, H., Lyons, E., Ferguson, A.A., Narzisi, G., Nelson, D.R., Blaby-Haas, C.E., Gschwend, A.R., Jiao, Y., Der, J.P., Zeng, F., Han, J., Min, X.J., Hudson, K.A., Singh, R., Grennan, A.K., Karpowicz, S.J., Watling, J.R., Ito, K., Robinson, S.A., Hudson, M.E., Yu, Q., Mockler, T.C., Carroll, A., Zheng, Y., Sunkar, R., Jia, R., Chen, N., Arro, J., Wai, C.M., Wafula, E., Spence, A., Han, Y., Xu, L., Zhang, J., Peery, R., Haus, M.J., Xiong, W., Walsh, J.A., Wu, J., Wang, M.L., Zhu, Y.J., Paull, R.E., Britt, A.B., Du, C., Downie, S.R., Schuler, M.A., Michael, T.P., Long, S.P., Ort, D.R., Somerville, C.R., Schopf, J.W., Gang, D.R., Jiang, N., Yandell, M., Depamphilis, C.W., Merchant, S.S., Paterson, A.H., Buchanan, B.B., Li, S., Shen-Miller, J. (2013) Genome of the long-living sacred lotus (Nelumbo nucifera Gaertn.). Genome Biol. 14:R41.

128. Glaesener, A.G., Merchant, S.S., Blaby-Haas, C.E. (2013) Iron economy in Chlamydomonas reinhardtii. Front Plant Sci. 4:337.

129. Urzica, E.I., Vieler, A., Hong-Hermesdorf, A., Page, M.D., Casero, D., Gallaher, S.D., Kropat, J., Pellegrini, M., Benning, C., Merchant, S.S. (2013) Remodeling of membrane lipids in iron-starved Chlamydomonas. J Biol Chem. 288:30246-58.

130. Block, A., Fristedt, R., Rogers, S., Kumar, J., Barnes, B., Barnes, J., Elowsky, C.G., Wamboldt, Y., Mackenzie, S.A., Redding, K., Merchant, S.S., Basset, G. (2013) Functional modeling identifies paralogous solanesyl diphosphate synthases that assemble the side chain of plastoquinone-9 in plastids. J. Biol. Chem. 288:27594-27606.

131. Blaby, I.K, Casero, D., Glaesener, A.G., Fitz-Gibbon, S., Mettler, T., Gallaher, S., Liu, B., Boyle, N.R., Kropat, J., Stitt, M., Johnson, S., Benning, C., Pellegrini, M., Merchant, S.S. (2013) Systems-Level Analysis of Nitrogen Starvation–Induced Modifications of Carbon Metabolism in a Chlamydomonas reinhardtii Starchless Mutant. Plant Cell 25: 4305-4323.

132. Blaby-Haas, C.E., Merchant, S.S. (2013) Metal Homeostasis: Sparing and salvaging metals in chloroplasts, in Encyclopedia of Inorganic and Bioinorganic Chemistry, edited by R.A. Scott. John Wiley & Sons, Ltd: Chichester, UK. DOI: 10.1002/9781119951438.eibc2113.

133. Blaby-Haas, C.E., Merchant, S.S. (2013) Iron sparing and recycling in a compartmentalized cell. Curr Opin Microbiol. Dec;16(6):677-85.

134. Fristedt, R., Scharff, L.B., Clarke, C.A., Wang, Q., Lin, C., Merchant, S.S., Bock, R. (2014) RBF1, a plant homolog of the bacterial ribosome-binding factor RbfA, acts in processing of the chloroplast 16S ribosomal RNA. Plant Physiol. Jan;164(1):201-15.

135. Schmollinger, S., Mühlhaus, T., Boyle, N.R., Blaby, I.K., Casero, D., Mettler, T., Kropat, J., Sommer, F., Hemme, D., Stitt, M., Pellegrini, M., Schroda, M., Merchant, S.S. (2014) Nitrogen-Sparing Mechanisms in Chlamydomonas Affect the Transcriptome, the Proteome, and Photosynthetic Metabolism. The Plant Cell, 2014 Apr 18;26(4):1410-1435.

136. Wakao, S., Chin, B.L., Ledford, H.K., Dent, R.M., Casero, D., Pellegrini, M., Merchant, S.S., Niyogi, K.K. (2014) Phosphoprotein SAK1 is a regulator of acclimation to singlet oxygen in Chlamydomonas reinhardtii. eLife 3:e02286.

137. Goodenough, U., Blaby, I.K., Casero, D., Gallaher, S., Goodson, C., Johnson, S., Lee, J.-H., Merchant, S.S., Pellegrini, M., Roth, R., Rusch, J., Singh, M., Umen, J.G., Weiss, T.L, Wulan, T. (2014) The path to triacylglyceride obesity in the sta6 strain of Chlamydomonas reinhardtii. Eukaryot. Cell, May;13(5):591-613.

138. Blaby, I.K., Blaby-Haas, C.E., Tourasse, N., Hom, E.F., Lopez, D., Aksoy, M., Grossman, A., Umen, J., Dutcher, S., Porter, M., King, S., Witman, G.B., Stanke, M., Harris, E.H., Goodstein, D., Grimwood, J., Schmutz, J., Vallon, O., Merchant, S.S., Prochnik, S. (2014) The Chlamydomonas genome project: a decade on. Trends Plant Sci. 2014 19:672-80.

139. Hong-Hermesdorf A, Miethke M, Gallaher SD, Kropat J, Dodani SC, Chan J, Barupala D, Domaille DW, Shirasaki DI, Loo JA, Weber PK, Pett-Ridge J, Stemmler TL, Chang CJ, Merchant SS. (2014) Subcellular metal imaging identifies dynamic sites of Cu accumulation in Chlamydomonas. Nat Chem Biol. 10:1034-42. News and Views. And more.

140. Fristedt, R., Williams-Carrier, R., Merchant, S.S., Barkan, A. (2014) A Thylakoid Membrane Protein Harboring a DnaJ-type Zinc Finger Domain is Required for Photosystem I Accumulation in Plants. J Biol Chem. 289:30657-67 [Available on 2015/10/31]

141. Blaby-Haas, C.E., Merchant, S.S. (2014) Lysosome-Related Organelles as Mediators of Metal Homeostasis. J Biol Chem. 289:28129-36.

142. Blaby-Haas CE, Padilla-Benavides T, Stübe R, Argüello JM, Merchant SS. (2014) Evolution of a plant-specific copper chaperone family for chloroplast copper homeostasis. Proc Natl Acad Sci U S A. 111:E5480-7.

143. Fristedt R, Herdean A, Blaby-Haas CE, Mamedov F, Merchant SS, Last RL, Lundin B. (2015) PHOTOSYSTEM II PROTEIN33, a Protein Conserved in the Plastid Lineage, Is Associated with the Chloroplast Thylakoid Membrane and Provides Stability to Photosystem II Supercomplexes in Arabidopsis. Plant Physiol. 167:481-92.

144. Anderson A, Laohavisit A, Blaby IK, Bombelli P, Howe CJ, Merchant SS, Davies JM, Smith AG. (2015) Exploiting algal NADPH oxidase for biophotovoltaic energy. Plant Biotechnol J. Jan 29. [Epub ahead of print]

145. Kropat J, Gallaher SD, Urzica EI, Nakamoto SS, Strenkert D, Tottey S, Mason AZ, Merchant SS. (2015) Copper economy in Chlamydomonas: Prioritized allocation and reallocation of copper to respiration vs. photosynthesis. Proc Natl Acad Sci U S A. 112:2644-51 PMC4352834. News and Views.

146. Allan CM, Awad AM, Johnson JS, Shirasaki DI, Wang C, Blaby-Haas CE, Merchant SS, Loo JA, Clarke CF. (2015) Identification of Coq11, a new coenzyme Q biosynthetic protein in the CoQ-synthome in Saccharomyces cerevisiae. J Biol Chem. 290: 7517-34.

148.     Fatihi, A., Latimer, S., Schmollinger, S., Block, A., Dussault, P., Vermaas, W., Merchant, S.S., Basset, G. (2015) A Dedicated Type II NADPH Dehydrogenase Performs a Hidden Penultimate Step in the Biosynthesis of Vitamin K in Photosynthetic Organisms. The Plant Cell, 27:1730-1741.

149.     Ort, D.R., Merchant, S.S., Alric, J., Barkan, A., Blankenship, R.E., Bock, R., Croce, R., Hanson, M.R., Hibberd, J., Lindstrom, D.L., Long, S.P., Moore, T.A., Moroney, J., Niyogi, K.K., Parry, M., Peralta-Yahya, P., Price, R., Redding, K., Spalding, M., van Wijk, K., Vermaas, W.F.J., von Caemmerer, S., Weber, A., Yeates, T., Yuan, J., Zhu, X. (2015) Redesigning photosynthesis to sustainably meet global food and bioenergy demand. Proc. Nat. Acad. Sci. USA, 112:8529-36. News and Views

150. Pérez-Martín, M. Blaby-Haas, C.E., Pérez-Pérez, M.E., Andrés-Garrido, A., Blaby, I.K., Merchant, S. S., Crespo, J.L. Activation of autophagy by metals in Chlamydomonas reinhardtii. Eukaryot. Cell, in press.

151. Lopez, D., Hamaji, T., Kropat, J., Morselli, M., Rubbi, L., Fitz-Gibbon, S., Gallaher, S.D., Merchant, S.S., Umen, J., Pellegrini, M. (2015) Dynamic changes in the transcriptome and methylome of Chlamydomonas reinhardtii throughout its sexual life cycle, Plant Physiol., in press.

152.Gallaher, S.D., Fitz-Gibbon, S., Glaesener, A., Pellegrini, M., Merchant, S.S. (2015) Chlamydomonas laboratory strain genome resource reveals unexpected mosaic of dramatic sequence variation, identifies true strain histories and enables strain-specific studies. The Plant Cell, in press.

153. Zones, J.M., Blaby, I.K., Merchant, S.S., Umen, J.G. (2015) High-resolution profiling of a synchronized diurnal transcriptome from Chlamydomonas reinhardtii reveals continuous cell and metabolic differentiation. The Plant Cell, in press.

From my sabbatical in the Schatz group at the Biozentrum in Basel

49. Koehler, C. M., Merchant, S., Oppliger, W., Schmid, K., Jarosch, E., Dolfini, L., Junne, T., Schatz, G., Tokatlidis, K. (1998) Tim9p, An Essential Partner Subunit of Tim10p for the Import of Mitochondrial Carrier Proteins. EMBO J. 17:6477-6486.

50. Koehler, C.M., Leuenberger, D., Merchant, S., Renold, A., Junne, T., Schatz, G. (1999) Human Deafness Dystonia Syndrome is a Mitochondrial Disease. Proc. Natl. Acad. Sci USA 96:2141-2146. see commentary

51. Koehler, C.M., Merchant, S., Schatz, G. (1999) How membrane proteins travel across the mitochondrial intermembrane space. Trends in Biochem. Sci. 24: 428-432.

From my sabbatical in the Schekman group at UC-Berkeley

56. Springer, S., Chen, E., Duden, R., Marzioch, M., Rowley, A., Hamamoto, S., Merchant, S., Schekman, R. (2000) The p24 proteins are not essential for vesicular transport in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 97:4034-4039. see commentary.

From my sabbatical in the Bock group at MPIMP-Potsdam

132. Fristedt, R., Scharff, L.B., Clarke, C.A., Wang, Q., Lin, C., Merchant, S.S., Bock, R. (2014) RBF1, a plant homologue of the bacterial ribosome-binding factor RbfA, acts in processing of the chloroplast 16S rRNA. Plant Physiol. 164:201-215.

147. Fristedt, R., Martins, N.F., Strenkert, D., Clarke, C.A., Suchoszek, M., Thiele, W., Schöttler, M.A., Merchant, S.S. (2015) The thylakoid membrane protein CGL160 supports CF1CF0 ATP synthase accumulation in Arabidopsis thaliana. PLoS One: 10:e0121658.

 

Books

1. Rochaix, J.-D., Goldschmidt-Clermont, M., Merchant, S., eds. (1998) Molecular Biology of Chlamydomonas: Chloroplasts and Mitochondria. Advances in Photosynthesis (Govindjee, series ed.), Kluwer Academic Publishers.

Video

Sabeeha Merchant and Elaine Tobin interview Winslow Briggs

Online Articles

Merchant, S.S. (2010) Green with envy: on citation of the chlorophyll assay. Commentary on Arnon DI (1949) Copper enzymes in isolated chloroplasts. Plant Physiol. 24:1-15.
 

CONTACT ME


 
Department of Chemistry and Biochemistry
UCLA
Box 951569 (post)
607 Charles E. Young Drive East (courier)
Los Angeles, CA  90095-1569
310-825-8300
310-206-5213
Skype logo Skype i.d. - sabeeha.merchant

GROUP MEMBERS - Merchant Group Resources

Former Ph.D. Students
Michael Allen - mallen278 at gmail.com - Commencement Ceremony and Party
Kent Hill - Graduation (1994) - Dinner (2003) - Voice of America Interview - Photos
Gregg Howe - Photos
Steven Karpowicz - skarp at chem.ucla.edu - Photos
Scott Hsieh - sihsieh at ucla.edu
Hong Hua Li - honghua_li2003 at yahoo.com - Photos
Jeffrey Moseley - jmoseley at sbcglobal.net - Photos
Stacie Nakamoto - nakamoto at chem.ucla.edu - Photos
Aimee Terauchi - aimee.terauchi at gmail.com - Photos
Zhiyi Xie - Zhiyi.Xie at gen-probe.com - Photos

Former Post-Doctoral Scholars
Ute Boronowsky - ute.boronowsky at web.de
Nanette Boyle - nanette.boyle at gmail.com - Photos
Madeli Castruita - madeli at chem.ucla.edu - Photos
Duane Culler
Jose del Campo - joseantonio.delcampo at gmail.com - Photos
Jen-Chih Chen - jchchen at gmail.com - Jen Chih, Shu Fen, Sabeeha Merchant and Others at National Taiwan University
Beth Dreyfuss - dreyfuss at chem.ucla.edu - Photos
Mats Eriksson - mats.eriksson at plantphys.umu.se - maer0003 at student.umu.se - The Eriksson Family 2007
Maria Felix Vazquez-Bermudez - mvazber at yahoo.es
Rikard Fristedt - rikard.fristedt at gmail.com - Photos
Patrice Hamel - hamel.16 at osu.edu - Boyer Award Recipient - March 2003
Anja Hemschemeier - anja.hemschemeier at ruhr-uni-bochum.de - Algae in Santa Monica
Anne Hong-Hermesdorf - ahhong at chem.ucla.edu - Photos - Winner of 2015 McCoy Award
Janette Kropat - kropat at chem.ucla.edu - Winner of 2013 McCoy Award
Sharon La Fontaine - sharonl at deakin.edu.au - Visit with Sharon
Joanne Long - jcl_1111 at yahoo.com- Jo is Co-Founder and President of IO Rodeo, Inc., an open source hardware consulting company for science and education.
Davin Malasarn - dmalasarn at gmail.com - Davin's Blog - Davin's First Book - Rey Martin with Sabeeha and Davin - Article on Rey's Research
M. Dudley Page - dpage at chem.ucla.edu - Dudley's Trip to the Computer History Museum
Jeanette Quinn - jeanette.quinn at agilent.com
Frederik Sommer - derferdi at gmail.com; frsommer@bio.uni-kl.de
Roland Stube - rstuebe at chem.ucla.edu - Photos
Stephen Tottey - steve.tottey at hotmail.com
Eugen I. Urzica - eugen.urzica at uni-muenster.de
Tomas Westergren - tomwest at chem.ucla.edu - Photos
Hiroaki Yamasaki - yamasaki at nibb.ac.jp - 2008 Visit

Former Visitors
Paola Barraco - Photos
Ian Blaby - iblaby_at_bnl.gov - Ian wins 2014 MBI Post Doc Award
Crysten Blaby-Haas - cblaby_at_bnl.gov - Crysten wins 2015 MBI Boyer-Peter Award
Delphine Bernard - db490 at cam.ac.uk
Diana Boy - dianaboy at chem.ucla.edu
Jan Cerveny - Jan.Cerveny at ucla.edu
Esperanza del Rio - esperanza at ibvf.csic.es
Petr Ent - petr.ent at seznam.cz
Mats Hansson - mats.hansson at plen.ku.dk - Fulbright Scholar - Photos
Marcus Miethke - miethke at chem.ucla.edu
Simona Stube - sstuebe at chem.ucla.edu

Ph.D. Students presently in the group
Anne Glaesener - anneg at chem.ucla.edu
Michael Leonard - michaelleonard at ucla.edu

Post-doctoral Scholars presently in the group
Stefan Schmollinger - schmolli at chem.ucla.edu
Daniela Strenkert - danielas at chem.ucla.edu

Visiting Researchers

Professional Staff
Sean Gallaher - gallaher at sent.com
Patrice Salome - salome at chem.ucla.edu

Technicians
Maria Gutierrez

MERCHANT LAB COLLABORATORS

Present
Chris Chang - chrischang_at_berkeley.edu - on visualization of sites of metal accumulation using fluorescent probes
Gilles Basset - gbasset2_at_unl.edu - on Chlamydomonas quinones and tocopherols
Arthur Grossman - arthurg at stanford.edu - on Chlamydomonas genomics
Mark Hildebrand - mhildebrand at ucsd.edu - on Cyclotella genomics
Ute Kraemer - ute.kraemer at rub.de - on Cu homeostasis in Arabidopsis - Ute Kraemer's Baby Elias! - Ute's Wedding!
Joseph Loo - jloo at chem.ucla.edu - on proteomic analysis of nutrient deficiency
Krishna Niyogi - niyogi at nature.berkeley.edu - algal genomics
Matteo Pellegrini - matteop at mcdb.ucla.edu - on next gen sequencing & genome annotation
Jennifer Pett-Ridge - pettridge2 at llnl.gov - on NanoSIMS analysis of Chlamydomonas cells
Eric Skaar - Eric.Skaar at Vanderbilt.edu- on heme oxidation
Timothy Stemmler - tstemmle at med.wayne.edu - on Xray analysis of metal accumulation in Chlamydomonas
Jim Umen - JUmen at danforthcenter.org - on Chlamydomonas transcriptomics

Past
Noam Adir - nadir at techunix.technion.ac.il - on metalloprotein structure
Christoph Benning - benning at cns.msu.edu - on lipids in Chlamydomonas
Maryse Block - block at dsvsud.cea.fr - on localization of chlorophyll biosynthesis enzymes
Jean-Pierre Carde - jean-pierre.carde at bordeaux.inra.fr - on localization of chlorophyll biosynthesis enzymes
Genevieve Dujardin - dujardin at cgm.cnrs-gif.fr - on mitochondrial cytochrome biogenesis
David Giedroc - giedroc at indiana.edu- on metal binding to SBP - Lecture at UCLA 2014
Ursula Goodenough - ursula at biology2.wustl.edu - on TAG synthesis in Chlamydomonas
Mats Hansson - mats.hansson at carlsberglab.dk Fulbright Scholar - on the aerobic oxidative cyclase in chlorophyll biosynthesis
Toshiharu Hase - enzyme at protein.osaka-u.ac.jp - on ferredoxin biochemistry
Michael Hippler - mhippler at uni-muenster.de - on molecular responses to Fe-deficiency
Peter Huijser - huijser at mpiz-koeln.mpg.de - on SBP domains
Poul Erik Jensen - peje at plen.ku.dk - on the aerobic oxidative cyclase in chlorophyll biosynthesis
David Knaff - david.knaff at ttu.edu - on ferredoxin biochemistry
Dan Kosman - camkos at acsu.buffalo.edu - on copper uptake
(Andrew) Zed Mason - zedmason at csulb.edu - on measurement of metalloproteins in Chlamydomonas
Lauren Mets - mets at uchicago.edu - on genetic analysis of Chlamydomonas mutants
Simon Prochnik - seprochnik at lbl.gov - Chlamydomonas genomics
Richard Sayre - rsayre at newmexicoconsortium.org - on chlorella transcriptomics
Steve Theg - smtheg at ucdavis.edu - on localization of plastid proteins
Todd Yeates - yeates at mbi.ucla.edu - on structural analysis of plastocyanin and cytochrome c6
Francis-Andre Wollman - wollman at ibpc.fr - on b and c type cytochrome mutants

PHOTOS AT MEETINGS OTHER PHOTOS

Sino-American Joint Photosynthesis Symposium (1991)
Brisbane, Australia (2001)
Lake Tahoe (2002
)
Chlamy Meeting (2002)
Gordon Research Conference (2002)
Ischia (2002)
Joshua Tree (2003)
Embo Workshop (2003
)
Embo Workshop (2006)
Bogorad Group Reunion at Legal Sea Foods in Boston at ASPB (2006)
Chlamydomonas Meeting in Freiburg (2007)
ICTPPO Meeting in Kyoto (2007)
Chlamydomonas Meeting in France (2008)
"The Unbearable Complexity of Life" - Tel Aviv, Israel (2008)
Chloroplast Biology Meeting - Taiwan (2008)
Keystone Symposium on Biofuels (2011) - Visit to the Singapore Botanical Garden
GRC Cell Biology of Metals Conference Group Photo (2011)
GRC Photosynthesis Conference Group Photo (2012)
ARPB Meeting Dinner in Zurich, October (2012)
Chlamy Group Photo (2012)

Light Sensing Symposium in honor of Jean-David Rochaix (2012)
GRC Cell Biology of Metals Conference Group Photo (2013)
- Candids at meeting

GSA Chlamy Group Photo (2014)
GRC Photosynthesis Conference Group Photo (2015)


UCLA Plant Biology (2003)
Plant Biologists at UCLA
Chem 161 - Spring 2008
Michele Wang's Graduation (2009)
Visit to Harz mountains with Prof. Ralf Mendel (2011)
En Route to Asilomar (2012)
Rey Martin's Graduation (2012)
Xenie & Jean Alric's New Baby (2014)
Chem 161 - Spring 2014
Farewell to Steven Simak

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Updated September 17, 2015