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Publications




2011-present

  1. Hui Ding, Andrew Roberts, Rocky Chiang and Patrick G. Harran (2018). Cascading auto-oxidative biproline guanylations form optically active dispacamide dimers and permit an eight-step synthesis of (−)-ageliferin, submitted.

  2. Brice Curtin, Francesco Manoni, Jiyong Park, Luke Sisto, Yu-hong Lam, Michel Gravel, Anne Roulston and Patrick G. Harran (2018). Assembly of Complex Macrocycles by Incrementally Analgamating Unprotected Peptides with a Designed Four-Armed Insert, J. Org. Chem., 83(6): 3090-3108.

  3. Francesco Manoni, Corentin Rumo, Liubo Li, and Patrick G. Harran (2018). Unconventional fragment usage enables a concise total synthesis of (-)-callyspongiolide. J. Am. Chem. Soc., 140(4): 1280-1284.

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  4. Patrick G. Harran, Peter Tontonoz, David Strugatsky, Hui Ding, and Emily Murzinski (2017). Inhibitors of Ghrelin O-Acyl Transferase. Provisional Patent Application. Filed Dec. 20, 2017

  5. Tyler K. Allred, Francesco Manoni and Patrick G. Harran (2017). Exploring the Boundaries of 'Practical': De Novo Synthesis of Complex Natural Product-Based Drug Candidates. Chemical Reviews, 117(18): 11994-12051.

  6. Michal Wieczorek, Joseph Tcherkezian, Cynthia Bernier, Andrea E. Prota, Sami Chaaban, Yannève Rolland, Claude Godbout, Mark A. Hancock, Joseph C. Arezzo, Ozhan Ocal, Cecilia Rocha, Natacha Olieric, Anita Hall, Hui Ding, Alexandre Bramoullé, Matthew G. Annis, George Zogopoulos, Patrick G. Harran, Thomas M. Wilkie, Rolf. A. Brekken, Peter M. Siegel, Michel O. Steinmetz, Gordon C. Shore, Gary Brouhard and Anne Roulston (2016). The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity. Sci. Transl. Med., 8, 365ra159. *For a highlight of this article, see Nature Reviews Drugs Discovery.

  7. Tristin E. Rose, Brice H. Curtin, Kenneth V. Lawson, Adam Simon, K. Houk and Patrick G. Harran (2016). On the prevalence of bridged macrocyclic pyrroloindolines formed in regiodivergent alkylations of tryptophan. Chem. Sci., 7, 4158-4166.

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  8. Hui Ding, Patrick L. DeRoy, Christian Perreault, Alexandre Larivée, Arshad Siddiqui, Charles G. Caldwell, Susan Harran and Patrick G. Harran (2015). Electrolytic Macrocyclizations: Scalable Synthesis of a Diazonamide-Based Drug Development Candidate. Angew. Chem Intl. Ed. Engl., 54, 4818-4822.

  9. Jack D. Bracken, Andrew D. Carlson, James H. Frederich, Mai Nguyen, Gordon C. Shore and Patrick G. Harran (2015). Tailored fragments of roseophilin selectively antagonize Mcl-1 in vitro. Tetrahedron Lett. (Special issue in honor of Harry Wasserman), 56, 3612-3616.

  10. Tristan E. Rose, Kenneth V. Lawson and Patrick G. Harran (2015). Large Ring-Forming Alkylations Provide Facile Access to Composite Macrocycles. Chem. Sci., 6, 2219-2223.

  11. Patrick G. Harran, Ryan A. Hollibaugh, Haixia Liu (2014). Small Lipopeptidomimetic Inhibitors of Ghrelin O-Acyl Transferase. US Provisional Patent Application #62/051,701. Filed September 17, 2014.

  12. Patrick G. Harran, James H. Frederich, Gordon Shore and Mai Nguyen (2014). MCL-1 Antagonists. US Provisional Patent Application #61/947,211. Filed March 3, 2014.

  13. Kenneth V. Lawson, Tristan E. Rose, Patrick G. Harran (2013). Template Constrained Macrocyclic Peptides Prepared from Native, Unprotected Precursors. Proc. Natl. Acad. Sci. (USA), 110 (40), E3753-E3760.

  14. Kenneth V. Lawson, Tristan E. Rose, Patrick G. Harran (2013). Template-induced macrocycle diversity through large-ring forming alkylations of tryptophan. Tetrahedron (Special issue in honor of P.A. Wender), 69 (36), 7683-7691.

  15. James H. Frederich, Jennifer K. Matsui, Randy O. Chang and Patrick G. Harran (2013). Substituted 2,2'-bipyrroles and pyrrolylfurans via intermediate isoxazolylpyrroles. Tetrahedron Lett., 54 (21), 2645-2647.

  16. James H. Frederich and Patrick G. Harran (2013). Modular Access to Complex Prodiginines: Total Synthesis of (+)-Roseophilin via its 2-Azafulvene Prototropisomer. J. Am. Chem. Soc., 135 (10), 3788-3791.

  17. Gelin Wang, Xiaoming Wang, Hong Yu, Shuguang Wei, Noelle Williams, Daniel L Holmes, Randal Halfmann, Jacinth Naidoo, Lai Wang, Lin Li, She Chen, Patrick G. Harran , Xiaoguang Lei, Xiaodong Wang (2013). Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nature Chemical Biology, 9, 84-89.

  18. Hui Ding, Andrew Roberts, and Patrick G. Harran (2013).Total synthesis of ageliferin via acyl N-amidinyliminium ion rearrangement. Chem. Sci., 4 (1), 303-306.

  19. Hui Ding, Andrew Roberts, and Patrick G. Harran (2012).Synthetic (±)-Axinellamines Deficient in Halogen. Angew. Chem Intl. Ed. Engl., 51, 4340-4343.

  20. Rachel M. Greer, Michael Peyton, Jill E. Larsen, Luc Girard, Yang Xie, Adi Gazdar, Patrick Harran, Lai Wang, Rolf A. Brekken, Xiaodong Wang, and John D. Minna (2011) SMAC mimetic (JP1201) sensitizes non small cell lung cancers to multiple chemotherapy agents in an IAP dependent but TNFα independent manner. Cancer Research, 71, 7640-7648.

  21. Kenneth V. Lawson, Tristan E. Rose, and Patrick G. Harran (2011) Synthesis of a Designed Sesquiterpenoid that Forms Useful Composites with Peptides and Related Oligomers. Tetrahedron Lett., 52, 653-654.