CURRICULUM VITAE

 

PERSONAL INFORMATION

Name:  Michael E. Jung

Date and Place of Birth:  May 14, 1947 in New Orleans, Louisiana

Marital Status:  Married, wife Alice

Mailing Address:   Department of Chemistry

                               University of California

                               Los Angeles, CA 90095-1569

Telephone:  (310) 825-7954              FAX: (310) 206-3722

email: jung@chem.ucla.edu

 

EDUCATIONAL BACKGROUND

Distinguished Professor Further Above Scale, UCLA, 2010 - present

Distinguished Professor, UCLA, 2004 - 2010

Professor Further Above Scale, UCLA, 2002 - 2004

Professor Above Scale, UCLA, 1998 - 2002

Professor VIII, UCLA, 1996 - 1998

Professor VII, UCLA, 1994 - 1996

Professor VI, UCLA, 1992 - 1994

Professor V, UCLA, 1990 - 1992

Professor IV, UCLA, 1988 - 1990

Professor III, UCLA, 1987 - 1988

Professor II, UCLA, 1985 - 1987

Professor I, UCLA, 1983 - 1985

Associate Professor III, UCLA, 1981 - 1983

Associate Professor I, UCLA, 1979 - 1981

Assistant Professor IV, UCLA, 1977 - 1979

Assistant Professor III, UCLA, 1976 - 1977

Assistant Professor II, UCLA, 1974 - 1976

NATO Postdoctoral Fellowship, Eidgenössische Technische Hochschule, Zürich, Switzerland, 1973 - 1974; Albert Eschenmoser, advisor

Ph.D., Columbia University, New York, New York, 1973; Gilbert Stork, advisor

B.A., Summa cum laude, Rice University, Houston, Texas, 1969; Richard Turner, advisor

 

PROFESSIONAL AFFILIATION

 

American Chemical Society, 1969 - present

The Chemical Society, 1971 - present

Phi Lambda Upsilon, 1968 - present

UCLA Cancer Center, 1975 - present

Division of Organic Chemistry, ACS, 1975 - present

Division of Medicinal Chemistry, ACS, 1975 - present

Sigma Xi, 1977 - present

American Men and Women of Science, Chemistry, 1977 - present

American Association for the Advancement of Science, 1979 - present

Molecular Biology Institute, UCLA, 2004 - present

California NanoSystems Institute (CNSI), UCLA, 2006 - present.

Director, UCLA Biosciences Synthetic Chemistry Core Facility, 2006 - present.

UCLA Medical School, Department of Molecular and Medical Pharmacology (Joint Appointment), 2014 - present.

National Academy of Inventors, 2015 - present.

 

COWORKERS

 

Current:  2 joint graduate students, 11 postdoctoral associates, 2 undergraduate students

Former:  92 PhD's granted, 9 MS's granted, 122 postdoctoral associates, 42 undergraduates, 21 research associates and technicians

 


HONORS AND AWARDS

Professional - University of California


2017

Plenary Lecturer, American Chemical Society Medicinal Chemistry Division and European Federation for Medicinal Chemistry Symposium, Philadelphia

2016

Glenn T. Seaborg Award Medalist, UCLA

2016

Keynote Speaker, Yao Yuan Symposium, Chicago, IL

2016

Richard C. Tolman Award, Southern California Section of the American Chemical Society

2016

Carl M. Franklin Lecturer, University of Southern California

2015

American Association of Cancer Research Team Science Award

2015

National Academy of Inventors Inductee

2012

Keynote Speaker, UCLA Department of Pharmacology Annual Retreat

2011

Visiting Professor, Université Pierre et Marie Curie, Paris, France

2011

Plenary Lecturer, Groupe Etude Chimie Organique Symposium, Aber Wra'ch, France

2011

Plenary Lecturer, First Mexican Meeting on Pure and Applied Chemistry, Mexico City

2011

Plenary Lecturer, USC Stauffer Symposium, Los Angeles, CA

2011

Plenary Lecturer, ACS Award Symposium Award in Industrial Chemistry, Anaheim, CA

2010

Plenary Lecturer, 14th International Congress on Hormonal Steroids, and Hormones and Cancer, Edinburgh

2010

Dr. Paul Janssen Lecture Series in Organic Chemistry Lecturer, Johnson & Johnson Pharmaceeutical R&D, Beerse, Belgium

2009

Herbert Newby McCoy Award Recipient, UCLA

2009

Plenary Lecturer, ZaCh Systems Symposium on Organic Synthesis, Paris

2009

Plenary Lecturer, Center for Cancer Research Eminent Lecture Series, National Cancer

2008

Organic Synthesis Symposium, 43rd Mexican Chemical Society National Meeting, Tijuana, Mexico

2008

Plenary Lecturer, Symposium in honor of Victor Marquez, American Chemical Society National Meeting, Philadelphia, PA

2008

Plenary Lecturer, Chemical Insights into Biological Processes, Center for Cancer Research, National Cancer Institute, Frederick, MD

2008

Plenary Lecturer, Symposium on Organic Synthesis, 91st National Meeting of the Canadian Society for Chemistry, Edmonton, Canada

2007

Wolfrom Award Symposium in honor of Muthiah Manoharan, 234th ACS National Meeting, Boston, MA

2006

Boehringer-Ingelheim Lecturer, University of British Columbia, Vancouver

2004

Plenary Lecturer, Ischia Advanced School of Organic Chemistry, Ischia, Italy

2004

Bristol-Myers Squibb Lecturer, University of Puerto Rico, Rio Piedras, PR

2003

Invited Professor, Université Pierre et Marie Curie, Paris

2002

Auspex Horizon Award, Auspex Pharmaceutical Co., Inc., San Diego, CA

2002

Plenary Lecturer, 60th Anniversary International Symposium on Organic Synthesis, Tokyo, Japan

2001

Plenary Lecturer, First International Symposium on Asymmetric Synthesis, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City

1999

Plenary Lecturer, Japan Pharmaceutical Society, Tokushima, Japan

1999

Plenary Lecturer, Japan Chemical Society, Tokyo, Japan

1998

Plenary Lecturer, 21st Gulf Coast Chemistry Conference, Pensacola, FL

1998

Invited Lecturer, XIII International Round Table on Nucleosides, Nucleotides and Their Biological Applications, Montpellier, France

1998

Invited Lecturer, 19th International Carbohydrate Symposium, La Jolla, CA

1998

Plenary Lecturer, Western Switzerland Lecture Tour

1998

Plenary Speaker, Spring Meeting, French Chemical Society, Paris

1998

Plenary Lecturer, Robert A. Welch Foundation

1997

Plenary Speaker, 2nd AFMC International Medicinal Chemistry Symposium (AIMECS 97), Seoul

1997

Invited Lecturer, 16th International Congress of Heterocyclic Chemistry, Montana State University, Bozeman, MT

1995

American Chemical Society Arthur C. Cope Scholar Award

1995

Plenary Lecturer, Gordon Conference on Purines, Pyrimidines, and Other Related Substances

1995

Plenary Lecturer, 5th French American Chemical Society (FACS) Conference

1992

Hanson-Dow Teaching Award, UCLA

1991

Herbert Newby McCoy Award Recipient, UCLA

1991

Fujii-Ohtsuka Professor, University of Tokushima, Tokushima, Japan

1988

Plenary Lecturer, 3rd Nozaki Conference, Sagamihara, Japan

1987

Glenn T. Seaborg Award Recipient

1987

Plenary Lecturer, Gordon Conference on Natural Products Chemistry

1987

Plenary Lecturer, Gordon Conference on Organic Reactions and Processes

1986

Inaugural UCLA Gold Shield Faculty Prize

1985

Plenary Lecturer, 9th Oxford Symposium on Organic Synthesis, Oxford

1982

Plenary Lecturer, 4th International Conference on Organic Synthesis, Tokyo

1981

Invited Participant, Twelfth Annual Workshop on Organic Synthesis in Natural Products Chemistry, Pingree Park, Colorado

1981

Plenary Lecturer, French Chemical Society Meeting, Paris (Spring)

1980

Fulbright-Hays Grant, U.S. Research Scholar Award

1980

American Cyanamid Young Researcher Award

1980

Plenary Lecturer, Gordon Conference on Organometallic Chemistry

1979

Alfred P. Sloan Foundation Research Fellow

1979

Camille and Henry Dreyfus Teacher-Scholar Grantee

1977

Eli Lilly Grantee

1978

University Distinguished Teaching Award

1978

Invited Speaker, Symposium for Creative Work in Synthetic Organic Chemistry, 175th ACS National Meeting, Anaheim

1978

Plenary Lecturer, 5th Annual Conference on Organosilicon Chemistry

1977

Invited Participant, Eight Annual Workshop on Organic Synthesis in Natural Products Chemistry, Dartmouth College Minary Conference Center, NH

1975

UCLA Summer Faculty Fellow


Postgraduate - Eidgenössische Technische Hochschule

1973        NATO Postdoctoral Fellow


Graduate - Columbia University

1973        Hammett Award for Research

1969-73   National Studies Foundation Predoctoral Fellow 


Undergraduate - Rice University

1968         Phi Beta Kappa

1967-69   ARCS Foundation Scholar 

1967-68   Blanche White Honor Scholar

1966-67   William Marsh Rice Scholar

1965-66   University Prize Scholar

 


FOUNDER

 

Enlibrium, Inc., La Jolla, CA, 2015 - present

LongLifeRx, Inc., Los Angeles, CA, 2014 - present

Trethera, Inc., Los Angeles, CA, 2013 - present

Eutropix, Inc., Los Angeles, CA, 2012 - present

MAX BioPharma, Inc., Los Angeles, CA, 2011 - present

Aragon Pharmaceuticals, Inc., La Jolla, CA, 2009 - 2013


MEMBER, BOARD OF DIRECTORS

 

LongLifeRx, Inc., Los Angeles, CA, 2014 - present


MEMBER, SCIENTIFIC ADVISORY BOARD

 

PMV Pharma, Philadelphia, PA, 2016 - present

Enlibrium, Inc., La Jolla, CA, 2015 - present

LongLifeRx, Inc., Los Angeles, CA, 2014 - present

Auspex Pharmaceuticals, Inc., Vista, CA, 2004 - 2012
Aragon Pharmaceuticals, San Diego, CA, 2009 - 2013
Trius Pharmaceuticals, San Diego, CA, 2006 - 2013
Neurocrine Biosciences, Inc., La Jolla, CA, 2003 - 2009

Medivation, Inc., San Francisco, CA, 2006 - 2009

Encore Pharmaceutical, Inc., Loma Linda, CA, 1998 - 2002

 

CONSULTANTSHIPS

 

Ionis (formerly Isis Pharmaceuticals, Carlsbad, CA, 1995 - present

ORIL, S.A., Bolbec, France, 1996 - present

Gilead Science Process Chemistry, Foster City, CA, 1996 - present

Gilead Science Medicinal Chemistry, Foster City, CA, 1999 - present

Institut de Recherche Servier, Servier Pharmaceutical Inc., Suresnes, France, 2000 - present

DuPont Crop Protection, Newark, DE, 2002 - present

Alnylam, Inc., Cambridge, MA, CA, 2003 - present

Celgene Pharmaceutical, Inc., San Diego, CA, 2003 - present

Prestwick Chemicals, Inc., Strasbourg, France 2007 - present

Vertex Pharmaceutical, San Diego, CA, 2008 - present

Diverchim, Montataire, France, 2011 - present

Pfizer, Inc., San Diego, CA, 2011 - present

Sofie Biosciences, Culver City, CA, 2011 - present

Crestone Pharma, Denver, CO, 2012 - present

Celgene Pharmaceutical, Inc., Cambridge, MA, 2013 - present

Receptos, Inc., La Jolla, CA, 2014 - present

PMV Pharma, Doylestown, PA, 2014 - present

ADRx, Westlake Village, CA, 2015 - present

Enlibrium, Inc., La Jolla, CA, 2015 - present

NantBioScience, Inc., Culver City, CA, 2016 - present

Travus/Resolute Pharma, 2016 - present

SUMO Biosciences, 2016 - present

Achaogen, 2016 - present

 

 


CURRENT RESEARCH

 

      The majority of the research personnel in my group are currently engaged in three general fields of interest: the development of new synthetic methods, the total synthesis of biologically active natural products, and medicinal chemistry. We are pursuing the total synthesis of several promising antitumor agents, e.g., tedanolide and 13-deoxytedanolide, dichlorolissoclimide, haterumaimide E, rugulosone, and gymnostatin G. The use of epoxide rearrangements in synthesis, e.g., the non-aldol aldol process, and others, is under investigation as well, especially for the synthesis of new antibiotics of the erythromycin class. We are also studying the use of various reactions (e.g., Diels-Alder reactions and [3,3] rearrangements) for the synthesis of biologically active molecules, e. g., the immunosuppressive agent brasilicardin A and the antibacterial agent mycosporulone. In particular, we are developing the mixed Lewis acid system, 5:1 AlBr3:AlMe3, in a variety of reactions, e.g., cycloadditions, nucleophilic additions, etc. We are developing new processes for the efficient synthesis of polyhydroxylated steroids, e.g., the cardioactive agent ouabain and the anticancer agent rhodexin A. We have several collaborative programs in medicinal chemistry, e.g.: a) the preparation and testing of novel small molecule androgen receptor antagonists which are very active at inhibiting the growth of castration-resistant prostate cancer; b) the preparation of various naturally occurring oxidation products of arachidonic acids, epoxy isoprostanes such as PEIPC (which are involved in the onset of atherosclerosis); c) the development of a new method of delivering antibacterial agents to resistant bacterial strains; d) the preparation and testing of new selective binders for the estrogen receptor as potential anti-breast cancer agents; e) the preparation and testing of small molecules which differentiate stem cells into osteoblasts for bone growth; f) the design and preparation of small molecule inhibitors of the growth of several enveloped viruses; g) the design and preparation of small molecule inhibitors of mycolyl transferase as anti-TB agents; h) the design and synthesis of novel small molecule radiomitigators; and i) the preparation of molecules that bind to the Sortase-A binding pocket to determine the structure of this important medicinal target and as potential antibacterial agents. We are also investigating the development of new reaction for synthesis, e.g., the non-aldol aldol process, the bridged Robinson annulation, and the mixed Lewis acid Diels-Alder process.




OTHER PUBLICATIONS


1.  M. E. Jung, "An Improved Procedure for the Conversion of Amines to Alcohols at Low Temperature; New Synthesis of Alkenes and Alkynes from Amines," Chemtracts 1990, 3, 392.

 

2.  M. E. Jung, "Iodomethyl Methyl Ether," Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd., 1995.

 

3.  M. E. Jung, "Trimethylsilyl iodide," Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd., 1995.

 

4.  M. E. Jung, "1-Trimethylsilyloxy-1,3-butadiene," Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd., 1995.

 

5.  M. E. Jung, "2-Trimethylsilyloxy-1,3-butadiene," Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd., 1995.

 

6.  M. E. Jung, "Triphenylcarbenium Tetrafluoroborate," Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd., 1995.

 

7.  W. J. Wechter, E. D. Murray, Jr., D. Kantoci, and M. E. Jung, "Characterization of Two New Endogenous Natriuretic Factors," Abstract, 29th Annual Meeting, American Society of Neurology, November 1996.

 

8.  Crostic No. 49 in Crostics, No. 115, Simon & Schuster, New York, NY, ed. T. H. Middleton, 1996.

 

9.  S. E. Denmark, M. E. Jung, A. Pfaltz, B. Giese, "Laudio for Professor Doctor Albert Eschenmoser," Synlett 1999, III.

 

10.  M. E. Jung, "Tungsten Hexachloride," Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd., 2006.




MEETING ABSTRACTS

1. Richardson, J. A.; Amantea, C. M.; Nguyen, K.; Jung, M. E.; Hahn, T. J.; Parhami, F. "Characterization of osteogenic oxysterols and their molecular mechanism(s) of action,"  J. Bone Mineral Res. 2005, 20, S414-S415 Suppl. 1.

2. Wechter, W. J.; Murray, E. D.; Kantoci, D.; Jung, M. E. "Characterization of two new endogenous natriuretic factors,"  J. Am. Soc. Nephrol. 1996, 7, A2867-A2867.


3. Anderson N. M.; Marquez-Garban, D. C.; Deng, G.; Chen, H.-W.; Jung, M. E.; Pietras, R. J. Proceedings of the American Association for the Advancement of Science, Pacific Division 2012, 31 (Part 1), 103-104. "Development of a new approach to kill non-small cell lung cancer with resistance to standard chemotherapy," [First Place Award in Health Sciences 2012]. 


 

 

SHORT COURSES

 

1.  Nov. 1980:    Upjohn Co., Kalamazoo, MI, "New Advances in the Use of Diels-Alder Reactions in Synthesis."

 

2.  Sept. 1985:    American Cyanamid Co., Agricultural Research Division, Princeton, NJ, "Silicon in Organic Synthesis."

 

3.  Sept. 1987:    Zhongshan University, Guangzhou, PRC, "Modern Organic Synthesis."

 

4.  Sept. 1987:    Zhongshan University, Guangzhou, PRC, "Silicon in Organic Synthesis."

 

5.  April 1996:    3M, St. Paul, MN, "Strategy and Design in Organic Synthesis."

 

6.  April 1998:    3M, St. Paul, MN, "New Methods in Heterocyclic Chemistry."

 

7.  Dec. 1999:    Neurocrine Biosciences, "Introduction to Modern Heterocyclic Chemistry."

 

8.  Mar. 2003:    Université Pierre et Marie Curie, Paris, "Modern Heterocyclic Chemistry."


9.  May 2008:    Vertex, Inc., San Diego, "Modern Heterocyclic Chemistry."


10.  Dec. 2011:    Université Pierre et Marie Curie, Paris, "Chimie Hétérocyclique (in French)."


 


PATENTS AND APPLICATIONS


1. Cross, B.; Los, M.; Doehner, R. F., Jr.; Ladner, D. W.; Johnson, J. L.; Jung, M. E.; Kamhi, V. M.; Tseng, S. S.; Finn, J. M.; Wepplo, P. J. (Assignee: American Cyanamid Company) "Preparation of Novel Fused Imidazolinylpyridines as Herbicides," Eur. Pat. Appl. 1987, EP 227932 A1, CAN 108:21884.

2. Jung, M. E.; Gardiner, J. M. (Assignee: The Regents of the University of California) "Process for the Synthesis of 2',3'-Dideoxynucleosides," US Patent 5,220,003 (June 15, 1993).

3. Cross, B.; Los, M.; Doehner, R. F., Jr.; Ladner, D. W.; Johnson, J. L.; Jung, M. E.; Kamhi, V. M.; Tseng, S. S.; Finn, J. M.; Wepplo, P. J. (Assignee: American Cyanamid Company) "(2-Imidazolin-2-yl) Fused Heteropyridine Compounds, Intermediates for the Preparation of and Use of Said Compounds as Herbicidal Agents," US Patent
5,252,538 (October 12, 1993).

4. Harrington, P. E.; Jung, M. E. (Assignee: American Cyanamid Company) "Stereoselective Bromination of β-Ribofuranosyl Amide: Synthesis of Herbicidal Analogues of Hydantocidin," US Patent 5,354,868 (October 11, 1994).

5. Jung, M. E.; D'Amico, D. C. (Assignee: The Regents of the University of California) "Stereospecific Synthesis of Aldols," US Patent 5,426,206 (June 20, 1995).

6. Harrington, P. E.; Jung, M. E. (Assignee: American Cyanamid Company) "Process and Intermediates for the Preparation of (+)-Hydantocidin and Analogs Thereof," US Patent 5,543,510 (August 6, 1996).

7. Jung, M. E.; Cook, P. D.; Kawasaki, A. M. (Assignee: Isis Pharmaceuticals) "Method for Removing Unreacted Electrophiles from a Reaction Mixture," US Patent 5,632,898 (May 27, 1997).

8. Fraser, A. S.; Manoharan, M.; Cook, P. D.; Jung, M. E.; Kawasaki, A. M. (Assignee: Isis Pharmaceuticals) "Preparation of DNA having improved hybridization affinity and nuclease resistance via alkylation of nucleosides with cyclic sulfates," US Patent 6,277,982 (August 21, 2001).

9. Manoharan, M.; Guzaev, A.; Jung, M. E.; Just, G.; Roland, A.; Wang, J. (Assignee: Isis Pharmaceuticals) "Solid phase synthesis of alkylphosphonate-linked oligodeoxyribonucleotides," US Patent 6,486,313 (November 26, 2002).

10. Jung, M. E.; Xu, Y. (Assignee: The Regents of the University of California) "Synthesis of L-Ribose and 2-Deoxy-L-Ribose from D-Ribose," PCT Int. Appl. WO9839347, A2 19980911.

11. Manoharan, M.; Just, G.; Guzaev, A.; Roland, A.; Wang, J.; Jung, M. E. (Assignee: Isis Pharmaceuticals) "Oligonucleotides having alkylphosphonate linkages and methods for their preparation," US Patent 7,049,432 (May 23, 2006).

12. Finn, J.; Morytko, M.; Parr, I. B.; Jung, M. (Assignee: Cubist Pharmaceuticals) "Preparation of novel depsipeptides as antibacterials," PCT Int. Appl. WO200314147 A1 20030220.

13. Morytko, M.; Zhang, Y.; Jung, M.; Finn, J.; Bouchard, M. (Assignee: Cubist Pharmaceuticals) "Preparation of lipopeptide stereoisomeric compounds as antibacterial agents," PCT Int. Appl. WO200317924, A2 20030306.

14. Sawyers, C. L.; Jung, M. E.; Chen, C. D.; Ouk, S.; Welsbie, D.; Tran, C.; Wongvipat, J.; Yoo, D. (Assignee: The Regents of the University of California) "Diarylhydantoin Compounds," US Patent 7,709,517 (May 4, 2010).

15. Jung, M. E.; Ouk, S.; Sawyers, C. L.; Chen, C. D.; Welsbie, D. (Assignee: The Regents of the University of California) "Methods and Materials for Assessing Prostate Cancer Therapies and Compounds," US Patent 7,718,684, (May 18, 2010).

16. Jung, M. E.; Ouk, S.; Sawyers, C. L.; Chen, C. D.; Welsbie, D. (Assignee: The Regents of the University of California) "Methods and Materials for Assessing Prostate Cancer Therapies and Compounds," PCT Int. Appl. WO 2005099693 A2 20051027 CAN 143:432632 AN 2005:1154369.

17. Manoharan, M.; Jung, M. E.; Rajeev, K. G.; Pandey, R. K.; Wang, G. (Assignee: Alnylam Pharmaceuticals) "Processes and Reagents for Oligonucleotide Synthesis and Purification," US Patent Appl. 20050267300, (December 1, 2005).

18. Whitten, J. P.; Pierre, F.; Regan, C.; Schwaebe, M.; Yiannikouros, G. P.; Jung, M. (Assignee: Cylene Pharmaceuticals) "Method for Converting Quinolone Esters into Quinolone Amides," US Patent 7,652,134 (January 26, 2010).

19. Manoharan, M.; Jung, M. E.; Rajeev, K. G.; Pandey, R. K.; Wang, G. (Assignee: Alnylam Pharmaceuticals) "Process and Reagents for Oligonucleotide Synthesis and Purification," PCT Int. Appl. WO 2005097817 A2 20051020.

20. Manoharan, M.; Jung, M. E.; Rajeev, K. G.; Pandey, R. K.; Wang, G. (Assignee: Alnylam Pharmaceuticals) "Processes and Reagents for Desilylation of Oligonucleotides," US Patent Appl. 20090005549, (January 1, 2009).

21. Manoharan, M.; Jung, M. E.; Rajeev, K. G.; Pandey, R. K.; Wang, G. (Assignee: Alnylam Pharmaceuticals) "Processes and Reagents for Sulfurization of Oligonucleotides," US Patent Appl. 20090187027 (July 23, 2009).

22. Whitten, J. P.; Pierre, F.; Regan, C.; Schwaebe, M.; Yiannikouros, G. P.; Jung, M. E. (Assignee: Cylene Pharmaceuticals) "Preparation of fused quinolone analogs which inhibit cell proliferation and/or induce cell apoptosis," US Patent Appl. 20060074089. Cont.-in-part of U.S. Ser. No. 149,007. US 2006074089 A1 20060406 CAN 144:370091 AN 2006:322120.

23.Whitten, J. P.; Pierre, F.; Regan, C.; Schwaebe, M.; Yiannikouros, G. P.; Jung, M. "Preparation of fused quinolone analogs which inhibit cell proliferation and/or induce cell apoptosis," PCT Int. Appl. WO 2006034113 A2 20060330 CAN 144:350684 AN 2006:301302.

24. Whitten, J. P.; Pierre, F.; Regan, C.; Schwaebe, M.; Yiannikouros, G. P.; Jung, M. E.; Nagasawa, J. Y.; Chua, P. (Assignee: Cylene Pharmaceuticals) "Process for the Preparation of Benzothiazole and Phenoxazine Compounds," US Patent Appl. 2006063761 A1 20060323 CAN 144:331460 AN 2006:273183.

25. Parhami, F.; Jung, M. E.; Dwyer, J. R.; Nguyen, K. (Assignee: The Regents of the University of California) "Oxysterol Compounds and the Hedgehog Pathway," US Patent Appl. 20100034781 (February 11, 2010).

26. Sawyers, C. L.; Jung, M. E.; Chen, C. D.; Ouk, S.; Welsbie, D.; Tran, C.; Wongvipat, J.; Yoo, D. (Assignee: The Regents of the University of California) "Diarylthiohydantoin Compounds," US Patent 8,183,274 (May 22, 2012).

27. Sawyers, C. L.; Jung, M. E.; Chen, C. D.; Ouk, S.; Welsbie, D.; Tran, C.; Wongvipat, J.; Yoo, D. (Assignee: The Regents of the University of California) "Treatment of Hyperprolifertative Disorders with Diarylthiohydantoin Compounds," US Patent 9,126,941 (September 8, 2015).

28. Parhami, F.; Jung, M. E.; Dwyer, J. R.; Nguyen, K. (Assignee: The Regents of the University of California) "Oxysterol Compounds and the Hedgehog Pathway," PCT Int. Appl. WO 2007098281 A2 20070830.

29. Jung, M. E.; Yoo, D.; Sawyers, C. L.; Tran, C. "Diarylhydantoin Compounds as Androgen Receptor Modulators," (Assignee: The Regents of the University of California) US Patent 8,110,594 (February 7, 2012).

30. Jung, M. E.; Yoo, D.; Sawyers, C. L.; Tran, C. (Assignee: The Regents of the University of California) "Diarylthiohydantoin Compounds," US Patent 8,680,291 (March 25, 2014).

31. Jung, M. E.; Yoo, D.; Sawyers, C. L.; Tran, C. (Assignee: The Regents of the University of California) "Diarylthiohydantoin Compounds," US Patent Appl. 20080139634.

32. Jung, M. E.; Sawyers, C. L.; Ouk, S.; Tran, C.; Wongvipat, J. (Assignee: The Regents of the University of California) "Androgen Receptor Modulators for the Treatment of Prostate Cancer and Androgen Receptor-Associated Diseases," US Patent 8,445,507 (May 21, 2013).

33. Jung, M. E.; Yoo, D.; Sawyers, C. L.; Tran, C. "Diarylhydantoin Compounds as Androgen Receptor Modulators," (Assignee: The Regents of the University of California) US Patent 8,648,105 (February 11, 2014).

34. Jung, M. E.; Sawyers, C. L.; Ouk, S.; Tran, C.; Wongvipat, J. (Assignee: The Regents of the University of California) "Androgen Receptor Modulators for the Treatment of Prostate Cancer and Androgen Receptor-Associated Diseases," US Patent 8,802,689 (August 8, 2014).

35. Jung, M. E.; Sawyers, C. L.; Ouk, S.; Tran, C.; Wongvipat, J. (Assignee: The Regents of the University of California) "Androgen Receptor Modulators for the Treatment of Prostate Cancer and Androgen Receptor-Associated Diseases," Japan Appl. 2014-83382 (March 27, 2007).

36. Jung, M. E.; Yoo, D.; Sawyers, C. L.; Tran, C. "Diarylhydantoin Compounds as Androgen Receptor Modulators," (Assignee: The Regents of the University of California) PCT Int. Appl. WO 2009055053 A2 20090430.

37. Sawyers, C. L.; Jung, M. E.; Yoo, D.; Tran, C. (Assignee: The Regents of the University of California) "Diarylhydantoin Compounds," US Patent Appl. 20090111864.

38. Parhami, F.; Jung, M. E.; Nguyen, K.; Yoo, D.; Kim, W.-K. (Assignee: The Regents of the University of California) "Oxysterols for Activation of Hedgehog Signaling, Osteoinduction, Antiadipogenesis, and Wnt Signaling," PCT Int. Appl. WO 2009073186 A1 20090611.

39. Lee, B; Jung, M. E.; Wolf, M. C.; Zhang, T. (Assignee: The Regents of the University of California) "Novel Antiviral Agents for Enveloped Viruses," PCT Int. Appl. WO 2010044924 A1 20100422.

40. Schiestl, R. H.; Rivina, Y. O.; Jung, M. E.; Damoiseaux, R. (Assignee: The Regents of the University of California) "Compounds and compositions for mitigating Radiation-Induced Tissue Damage and Lethality," US Patent 9,045,474.

41. Jung, M. E.; Clubb, R. T.; Yi, S. W.; Suree, N.; Clemens, J. J. (Assignee: The Regents of the University of California) "Preparation of pyridazin-3-one Derivatives as Sortase A Inhibitors," PCT Int. Appl. WO 2011028492 A2 20110310.

42. Manoharan, M.; Rajeev, K. G.; Jayaraman, M.; Butler, D.; Jung, M. E. (Assignee: Alnylam Pharmaceuticals) "Lipid compositions for the delivery of nucleic acid therapeutics," PCT Int. Appl. WO 2010129709.

43. Parhami, F.; Kim, W.-K.; Jung, M. E.; Nguyen, K. (Assignee: The Regents of the University of California) "Inhibition of peroxisome proliferator activated receptor gamma expression in preadipocyte cells by oxysterols," US Patent 8,022,052 (September 20, 2011).

44. Jung, M. E.; Clubb, R. T.; Yi, S. W.; Suree, N.; Clemens, J. J. (Assignee: The Regents of the University of California) "Preparation of pyridazin-3-one Derivatives as Sortase A Inhibitors," PCT Int. Appl. WO 2011028492 A2 20110310.

45. Manoharan, M.; Jayaprakash, N. K.; Rajeev, K. G.; Jung, M. E. (Assignee: Alnylam Pharmaceuticals) "Monomers and oligonucleotides comprising cycloaddition adducts," PCT Int. Appl. (2011), WO 2011100131 A2 20110818.

46. Parhami, F.; Jung, M. E.; Nguyen, K. T.; Matsui, W.; Yoo, D.; Meliton, V. (Assignee: The Regents of the University of California) "Oxysterols that activate liver X receptor signaling and inhibit hedgehog signaling," PCT Int. Appl. WO 2011103175 A2.

47. Lee, B; Jung, M. E.; Lee, J.; Vigant, F.; Bradley, P.; Wolf, M. C.; Hajagos, B. E. (Assignee: The Regents of the University of California) "Broad Spectrum Antiviral and Antiparasitic Agents," PCT Int. Appl. WO 2011130419 A2 20111020.

48. Chen, Z.; Creighton, C.; Cunningham, M.; Finn, J.; Hilgers, M.; Jung, M. E.; Kohnen, L. A.; Lam, T.; Li, X.; Stidham, M.; Tari, L.; Trzoss, M.; Zhang, J. (Assignee: Trius Therapeutics, Inc.) "Dihydrofolate Reductase Inhibitors," PCT Int. Appl. WO 2011153310 A1 20111208.

49. Manoharan, M.; Rajeev, K. G.; Jayaraman, M.; Jung, M. E. (Assignee: Alnylam Pharmaceuticals) "Methods and compositions for delivery of active agents," PCT Int. Appl. WO 2012016184 A2 20120202.

50. Gatti, R. A.; Du, L.; Damoiseuax, R.; Lai, C.-H.; Jung, M. E.; Ku, J.-M.; Bertoni, C. (Assignee: The Regents of the University of California) "Premature-termination-codons readthrough compounds," PCT Int. Appl. WO 2012021707 A2 20120216.

51. Bensen, D.; Finn, J.; Lee, S. J.; Chen, Z.; Lam, T. T.; Li, X.; Trzoss, M.; Jung, M. E.; Nguyen, T. B.; Lightstone, F.; Tari, L. W.; Zhang, J.; Aristoff, P.; Phillipson, D. W.; Wong, S. E. (Assignee: Trius Therapeutics, Inc.) "Pyrimidoindole derivatives as gyrase inhibitors and their preparation and use as antibacterials," PCT Int. Appl. (2012), WO 2012125746 A1 20120920.

52. Gatti, R. A.; Du, L.; Hu, H.; Damoiseuax, R.; Jung, M. E.; Ku, J.-M.; Completo, G. (Assignee: The Regents of the University of California) "Premature-termination-codons readthrough compounds," PCT Int. Appl. WO 2013142346 A1 20130926.

53. Pietras, R. J.; Jung, M. E.; Marquez-Garban, D. C.; Deng, G. (Assignee: The Regents of the University of California) "Preparation of parthenolide analog, compositions and methods for treating cancer," PCT Int. Appl. WO 2013152032 A1 20131010.

54. Parhami, F.; Jung, M. E.; Stappenbeck, F.; Pierce, W. M.; Taylor, K. G.; Merten, K. E. (Assignee: The Regents of the University of California) "Novel oxysterol analogue, Oxy149, induces osteogenesis and hedgehog signaling and inhibits adipogenesis," PCT Int. Appl. WO 2013169397 A1 20131114.

55. Witte, O.; Clark, P. M.; Castillo, B. G. F.; Jung, M. E.; Evdokimov, N. M (Assignee: The Regents of the University of California) "A positron emission tomography probe to monitor selected sugar metabolism in vivo," PCT Int. Appl. WO 2013170085 A1 20131114.

56. Parhami, F.; Jung, M. E.; Stappenbeck, F. (Assignee: The Regents of the University of California) "Oxysterol analogue Oxy133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis," PCT Int. Appl. WO 2013169399 A1 20131114.

57. Pietras, R. J.; Jung, M. E.; Marquez-Garban, D. C.; Deng, G. (Assignee: The Regents of the University of California) "Compounds and Methods of Treating Cancer," PCT Int. Appl. WO 2013188452 A1 20131219.

58. Bensen, D.; Borchardt, A.; Chen, Z.; Finn, J. M.; Lam, T. T.; Lee, S. J.; Li, X.; Tari, L. W.; Teng, M.; Trzoss, M.; Zhang, J.; Jung, M. E.; Lightstone, F. C.; Wong, S. E.; Nguyen, T. B. (Assignee: Trius Therapeutics, Inc.) "Preparation of pyrimidoindole derivatives as gyrase inhibitors for use as antibacterial agents," PCT Int. Appl. (2014), WO 2014043272 A1 20140320.

59. Radu, C. G.; Jung, M. E.; Satyamurthy, N.; Murphy, J. M.; Nathanson, D. A.; Czernin, J.; Lavie, A.; Armijo, A. (Assignee: The Regents of the University of California) "Small molecule inhibitors of nucleotide metabolism," PCT/US2012/028259.

60. Jung, M. E.; Yoo, D.; Sawyers, C. L.; Tran, C. Wongvipat, J. (Assignee: The Regents of the University of California) "Diarylhydantoin Compounds," US Patent 8,648,105 (Feb. 11, 2014).

61. Gillespie, E.; Damoiseaux, R.; Ho, C.-L. C.; Chamberlain, B. T.; Jung, M. E.; Bradley, K. A. (Assignee: The Regents of the University of California) "Protective molecules against anthrax toxin," PCT Int. Appl. (2014), WO 2014113607 A1 20140724.

62. Pietras, R. J.; Jung, M. E. (Assignee: The Regents of the University of California) "Methods of Using Estrogen Receptor-β Ligands as Radiation Mitigators," U.S. Pat. Appl. Publ. (2015), US 20150018398 A1.

63. Radu, C. G.; Li, Z.; Gipson, R. M.; Wang, J.; Satyamurthy, N.; Lavie, A.; Murphy, J. M.; Nathanson, D. A.; Jung, M. E. (Assignee: The Regents of the University of California) "Deoxycytidine Kinase Inhibitors," PCT Int. Appl. (2015), WO 2015023776 A2.

64. Pietras, R. J.; Jung, M. E.; Marquez-Garban, D. C.; Deng, G. (Assignee: The Regents of the University of California) "Compositions and Methods for Treating Cancer," US Patent Appl. 2015/0031725A1.

65. Huang, J.; Chin, R.; Diep, S.; Pai, M. Y.; Lomenick, B. E.; Fu, X.; Reue, K.; Vergnes, L.; Jung, M. E.; Deng, G.; et al (Assignee: The Regents of the University of California) "Compositions and Methods for Treating Aging and Age-related Diseases and Symptoms," PCT Int. Appl. (2015), WO 2015123229 A1 20150820.

66. Jagodzinska, B.; Campagna, J.; Pham, J.; Jung, M. E.; John, V.; Rao, R.; Bredesen, D. E. (Assignee: The Regents of the University of California), "Preparation of alaproclate and analogs as ApoE4-targeted therapeutics that increase SirT1," PCT Int. Appl. (2016), WO 2016028910 A1 20160225.

67. Pietras, R. J.; Jung, M. E.; Marquez-Garban, D. C.; Deng, G. (Assignee: The Regents of the University of California) "Preparation of 11β-Aryloxy Estradiols as Estrogen Receptor Modulators," PCT Int. Appl. (2016), WO 2016085825 A1 20160602.

68. Campbell, D.; Jung, M. E. (Assignee: Enlibrium, Inc.) "Imidocarbonimidic Diamide Analogs," US Prov. Patent Appl. No. 62/345,708 (2016) (June 3, 2016).

69. Jung, M. E.; Voskuhl, R. (Assignee: The Regents of the University of California) "Estrogen Receptor-β for the Treatment of Neurodegenerative Diseases," US Patent Appl. (2016), 62/385,275.

70. Jung, M. E.; Voskuhl, R. (Assignee: The Regents of the University of California) "Estrogen Receptor-β Ligands for the Treatment of Neurodegenerative Diseases," US Patent Appl. (2016), 62/393,430.

71. Parhami, F.; Jung, M. E.; Stappenbeck, F. (Assignee: The Regents of the University of California) "Oxysterol analogue Oxy133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis," U.S. Pat. Appl. Publ. (2015), US 20150118277 A1 Apri 30, 2015.

72. Manoharan, M.; Rajeev, K. G.; Jayaraman, M.; Jung, M. E. (Assignee: Alnylam Pharmaceuticals) "Methods and compositions for delivery of active agents," U.S. Pat. Appl. Publ. (2013), US 20130323269 A1 December 5, 2013.

73. Witte, O.; Clark, P. M.; Castillo, B. G. F.; Jung, M. E.; Evdokimov, N. M (Assignee: The Regents of the University of California) "A positron emission tomography probe to monitor selected sugar metabolism in vivo," U.S. Pat. Appl. Publ. (2015), US 20150133777 A1 May 14, 2015.

74. Parhami, F.; Jung, M. E.; Stappenbeck, F.; Pierce, W.; Taylor, K. G.; Merten, K. E. (Assignee: The Regents of the University of California) "Novel oxysterol analogue, Oxy149, induces osteogenesis and hedgehog signaling and inhibits adipogenesis," U.S. Pat. Appl. Publ. (2015), US 20150140059 A1 May 21, 2015.

75. Gatti, R. A.; Du, L.; Hu, H.; Damoiseuax, R.; Jung, M. E.; Ku, J.-M.; Completo, G. (Assignee: The Regents of the University of California) "Premature-termination-codons readthrough compounds," U.S. Pat. Appl. Publ. (2015), 20150051251 A1 20150219.

76. Jung, M. E.; Clubb, R. T.; Yi, S. W.; Suree, N.; Clemens, J. J. (Assignee: The Regents of the University of California) "Sortase A Inhibitors," US Pat. Appl. Publ. (2012), US 20120149710 A1 20120614.

77. Manoharan, M.; Rajeev, K. G.; Jayaraman, M.; Butler, D.; Jung, M. E. (Assignee: Alnylam Pharmaceuticals) "Liquid compositions," US Pat. Appl. Publ. (2012), US 20120128760 A1 20120524.

78. Lee, B; Jung, M. E.; Wolf, M. C.; Zhang, T. (Assignee: The Regents of the University of California) "Novel Antiviral Agents for Enveloped Viruses," US Pat. Appl. Publ. (2012), US 20120219613 A1 20120830.

Summary: 24 issued patents; 54 patent applications (53 pending).



 

INVITED LECTURES

 

609 Lectures, seminars, and presentations at international and national chemical meetings and symposia, academic institutions, and industrial institutions from 1973-2017.

 

 


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