CURRICULUM VITAE
PERSONAL INFORMATION
Name: Michael E. Jung
Date and Place of Birth: May 14, 1947 in New Orleans, Louisiana
Marital Status: Married, wife Alice
Mailing Address: Department of Chemistry
University of California
Los Angeles, CA 90095-1569
Telephone: (310) 825-7954 FAX: (310) 206-3722
email: jung@chem.ucla.edu
EDUCATIONAL BACKGROUND
Distinguished Professor Further Above Scale, UCLA, 2010 - present
Distinguished Professor, UCLA, 2004 - 2010
Professor Further Above Scale, UCLA, 2002 - 2004
Professor Above Scale, UCLA, 1998 - 2002
Professor VIII, UCLA, 1996 - 1998
Professor VII, UCLA, 1994 - 1996
Professor VI, UCLA, 1992 - 1994
Professor V, UCLA, 1990 - 1992
Professor IV, UCLA, 1988 - 1990
Professor III, UCLA, 1987 - 1988
Professor II, UCLA, 1985 - 1987
Professor I, UCLA, 1983 - 1985
Associate Professor III, UCLA, 1981 - 1983
Associate Professor I, UCLA, 1979 - 1981
Assistant Professor IV, UCLA, 1977 - 1979
Assistant Professor III, UCLA, 1976 - 1977
Assistant Professor II, UCLA, 1974 - 1976
NATO Postdoctoral Fellowship, Eidgenössische Technische Hochschule, Zürich, Switzerland, 1973 - 1974; Albert Eschenmoser, advisor
Ph.D., Columbia University, New York, New York, 1973; Gilbert Stork, advisor
B.A., Summa cum laude, Rice University, Houston, Texas, 1969; Richard Turner, advisor
PROFESSIONAL AFFILIATION
American Chemical Society, 1969 - present
The Chemical Society, 1971 - present
Phi Lambda Upsilon, 1968 - present
UCLA Cancer Center, 1975 - present
Division of Organic Chemistry, ACS, 1975 - present
Division of Medicinal Chemistry, ACS, 1975 - present
Sigma Xi, 1977 - present
American Men and Women of Science, Chemistry, 1977 - present
American Association for the Advancement of Science, 1979 - present
Molecular Biology Institute, UCLA, 2004 - present
California
NanoSystems Institute (CNSI), UCLA, 2006 - present.
Director, UCLA Biosciences Synthetic Chemistry Core Facility, 2006 - present.
COWORKERS
Current:
7 graduate students, 10 postdoctoral associates, 1 undergraduate researcher
Former: 83 PhD's granted, 7 MS's granted, 104 postdoctoral associates, 40 undergraduates, 21 research associates and technicians
HONORS AND AWARDS
Professional - University of California
|
2011 |
Plenary Lecturer, First Mexican Meeting on Pure and Applied Chemistry, Mexico City | |
|
2011 |
Plenary Lecturer, USC Stauffer Symposium, Los Angeles, CA | |
|
2011 |
Plenary Lecturer, ACS Award Symposium Award in Industrial Chemistry, Anaheim, CA | |
|
2010 |
Plenary Lecturer, 14th International Congress on Hormonal Steroids, and Hormones and Cancer, Edinburgh | |
|
2010 |
Dr. Paul Janssen Lecture Series in Organic Chemistry Lecturer, Johnson & Johnson Pharmaceeutical R&D, Beerse, Belgium | |
| 2009 | Herbert Newby McCoy Award Recipient, UCLA | |
| 2009 | Plenary Lecturer, ZaCh Systems Symposium on Organic Synthesis, Paris | |
| 2009 | Plenary Lecturer, Center for Cancer Research Eminent Lecture Series, National Cancer | |
| 2008 | Organic Synthesis Symposium, 43rd Mexican Chemical Society National Meeting, Tijuana, Mexico | |
| 2008 | Plenary Lecturer, Symposium in honor of Victor Marquez, American Chemical Society National Meeting, Philadelphia, PA | |
| 2008 | Plenary Lecturer, Chemical Insights into Biological Processes, Center for Cancer Research, National Cancer Institute, Frederick, MD | |
| 2008 | Plenary Lecturer, Symposium on Organic Synthesis, 91st National Meeting of the Canadian Society for Chemistry, Edmonton, Canada | |
| 2007 | Wolfrom Award Symposium in honor of Muthiah Manoharan, 234th ACS National Meeting, Boston, MA | |
| 2006 | Boehringer-Ingelheim Lecturer, University of British Columbia, Vancouver | |
| 2004 | Plenary Lecturer, Ischia Advanced School of Organic Chemistry, Ischia, Italy | |
| 2004 | Bristol-Myers Squibb Lecturer, University of Puerto Rico, Rio Piedras, PR | |
| 2003 | Invited Professor, Université Pierre et Marie Curie, Paris | |
| 2002 | Auspex Horizon Award, Auspex Pharmaceutical Co., Inc., San Diego, CA | |
| 2002 | Plenary Lecturer, 60th Anniversary International Symposium on Organic Synthesis, Tokyo, Japan | |
| 2001 | Plenary Lecturer, First International Symposium on Asymmetric Synthesis, Universidad Nacional Autonoma de Mexico (UNAM), Mexico City | |
| 1999 | Plenary Lecturer, Japan Pharmaceutical Society, Tokushima, Japan | |
| 1999 | Plenary Lecturer, Japan Chemical Society, Tokyo, Japan | |
| 1998 | Plenary Lecturer, 21st Gulf Coast Chemistry Conference, Pensacola, FL | |
| 1998 | Invited Lecturer, XIII International Round Table on Nucleosides, Nucleotides and Their Biological Applications, Montpellier, France | |
| 1998 | Invited Lecturer, 19th International Carbohydrate Symposium, La Jolla, CA | |
| 1998 | Plenary Lecturer, Western Switzerland Lecture Tour | |
| 1998 | Plenary Speaker, Spring Meeting, French Chemical Society, Paris | |
| 1998 | Plenary Lecturer, Robert A. Welch Foundation | |
| 1997 | Plenary Speaker, 2nd AFMC International Medicinal Chemistry Symposium (AIMECS 97), Seoul | |
| 1997 | Invited Lecturer, 16th International Congress of Heterocyclic Chemistry, Montana State University, Bozeman, MT | |
| 1995 | American Chemical Society Arthur C. Cope Scholar Award | |
| 1995 | Plenary Lecturer, Gordon Conference on Purines, Pyrimidines, and Other Related Substances | |
| 1995 | Plenary Lecturer, 5th French American Chemical Society (FACS) Conference | |
| 1992 | Hanson-Dow Teaching Award, UCLA | |
| 1991 | Herbert Newby McCoy Award Recipient, UCLA | |
| 1991 | Fujii-Ohtsuka Professor, University of Tokushima, Tokushima, Japan | |
| 1988 | Plenary Lecturer, 3rd Nozaki Conference, Sagamihara, Japan | |
| 1987 | Glenn T. Seaborg Award Recipient | |
| 1987 | Plenary Lecturer, Gordon Conference on Natural Products Chemistry | |
| 1987 | Plenary Lecturer, Gordon Conference on Organic Reactions and Processes | |
| 1986 | Inaugural UCLA Gold Shield Faculty Prize | |
| 1985 | Plenary Lecturer, 9th Oxford Symposium on Organic Synthesis, Oxford | |
| 1982 | Plenary Lecturer, 4th International Conference on Organic Synthesis, Tokyo | |
| 1981 | Invited Participant, Twelfth Annual Workshop on Organic Synthesis in Natural Products Chemistry, Pingree Park, Colorado | |
| 1981 | Plenary Lecturer, French Chemical Society Meeting, Paris (Spring) | |
| 1980 | Fulbright-Hays Grant, U.S. Research Scholar Award | |
| 1980 | American Cyanamid Young Researcher Award | |
| 1980 | Plenary Lecturer, Gordon Conference on Organometallic Chemistry | |
| 1979 | Alfred P. Sloan Foundation Research Fellow | |
| 1979 | Camille and Henry Dreyfus Teacher-Scholar Grantee | |
| 1977 | Eli Lilly Grantee | |
| 1978 | University Distinguished Teaching Award | |
| 1978 | Invited Speaker, Symposium for Creative Work in Synthetic Organic Chemistry, 175th ACS National Meeting, Anaheim | |
| 1978 | Plenary Lecturer, 5th Annual Conference on Organosilicon Chemistry | |
| 1977 | Invited Participant, Eight Annual Workshop on Organic Synthesis in Natural Products Chemistry, Dartmouth College Minary Conference Center, NH | |
| 1975 | UCLA Summer Faculty Fellow |
Postgraduate
- Eidgenössische Technische
Hochschule
1973
Hammett
Award for Research
Graduate
- Columbia University
Undergraduate
- Rice University
1968 Phi Beta Kappa
1967-69 ARCS Foundation Scholar
1967-68 Blanche White Honor Scholar
1966-67 William Marsh Rice Scholar
1965-66 University Prize Scholar
FOUNDER
Aragon Pharmaceuticals, Inc., La Jolla, CA, 2009 - present
MAX BioPharma, Inc., Los Angeles, CA, 2011 - present
MEMBERSHIP ON
SCIENTIFIC ADVISORY BOARDS
Auspex
Pharmaceuticals, Inc., Vista, CA, 2004 - present
Trius
Pharmaceuticals, San Diego,
CA, 2006 - present
Neurocrine
Biosciences, Inc., La Jolla, CA, 2003 - 2009
Medivation, Inc., San Francisco, CA, 2006 - 2009
Encore Pharmaceutical, Inc., Loma Linda, CA, 1998 - 2002
CONSULTANTSHIPS
ORIL, S.A., Bolbec, France, 1996 - present
Gilead Science Process Chemistry, Foster City, CA, 1996 - present
Gilead Science Medicinal Chemistry, Foster City, CA, 1999 - present
Institut de Recherche Servier, Servier Pharmaceutical Inc., Suresnes, France, 2000 - present
DuPont Crop Protection, Newark, DE, 2002 - present
Alnylam, Inc., Cambridge, MA, CA, 2003 - present
Cylene Pharmaceuticals, San Diego, CA, 2003 - present.
Celgene Pharmaceutical, Inc., San Diego, CA, 2003 - present
Auspex Pharmaceuticals, Inc., Vista, CA, 2004 - present
ArQule Pharmaceutical Inc., Woburn, MA, 2005 - present
Abraxis BioSciences, Inc., Santa Monica, CA, 2005 - present
Trius Pharmaceuticals, San Diego, CA 2006 - present
ZaCh System, Inc. (formerly PPG-Sipsy), Angers, France 2007 - present
Prestwick Chemicals, Inc., Strasbourg, France 2007 - present
GlaxoSmithKline (GSK) Pharmaceuticals, Inc., Collegeville, PA 2008 - present
GlaxoSmithKline (GSK) Pharmaceuticals, Inc., Res. Triangle Park, NC, 2008 - present
Vertex Pharmaceutical, San Diego, CA, 2008 - present
AllerQuest LLC, West Hartford, CT, 2010 - present
Diverchim, Montataire, France, 2011 - present
Sofie Biosciences, Culver City, CA, 2011 - present
The majority of the research personnel in my group are currently engaged in three general fields of interest: the development of new synthetic methods, the total synthesis of biologically active natural products, and medicinal chemistry. We are pursuing the total synthesis of several promising antitumor agents, e.g., tedanolide and 13-deoxytedanolide, dichlorolissoclimide, haterumaimide E, the auripyrones, the cucurbitacins, rugulosone, and gymnostatin G. The use of epoxide rearrangements in synthesis, e.g., the non-aldol aldol process, and others, is under investigation as well, especially for the synthesis of new antibiotics of the erythromycin class. We are also studying the use of various reactions (e.g., Diels-Alder reactions and [3,3] rearrangements) for the synthesis of biologically active molecules, e. g., the immunosuppressive agent brasilicardin A; the antibiotic fusidic acid; the acetylcholinesterase inhibitors, the arisugacins and territrems; the antibacterial agent mycosporulone; and multiple drug resistance reversing agents such as welwitindolinone C. In particular, we are developing the mixed Lewis acid system, 5:1 AlBr3:AlMe3, in a variety of reactions, e.g., cycloadditions, nucleophilic additions, etc. We are developing new processes for the efficient synthesis of polyhydroxylated steroids, e.g., the cardioactive agent ouabain and the anticancer agent rhodexin A. We have several collaborative programs in medicinal chemistry, e.g.: a) the preparation and testing of novel small molecule androgen receptor antagonists which are very active at inhibiting the growth of castration-resistant prostate cancer; b) the preparation of various naturally occurring oxidation products of arachidonic acids, epoxy isoprostanes such as PEIPC (which are involved in the onset of atherosclerosis); c) the development of a new method of delivering antibacterial agents to resistant bacterial strains; d) the preparation and testing of new selective binders for the estrogen receptor as potential anti-breast cancer agents; e) ) the preparation and testing of small molecules which differentiate stem cells into osteoblasts for bone growth; f) the design and preparation of small molecule inhibitors of the growth of several enveloped viruses, e.g., Nipah virus; g) the design and preparation of small molecule inhibitors of mycolyl transferase as anti-TB agents; h) the design and synthesis of novel small molecule radiomitigators; and i) the preparation of molecules that bind to the Sortase-A binding pocket to determine the structure of this important medicinal target and as potential antibacterial agents. We are also investigating the development of new reaction for synthesis, e.g., the non-aldol aldol process, the bridged Robinson annulation, and the mixed Lewis acid Diels-Alder process.
OTHER PUBLICATIONS
1. M. E. Jung, "An Improved Procedure for the Conversion of Amines to Alcohols at Low Temperature; New Synthesis of Alkenes and Alkynes from Amines," Chemtracts 1990, 3, 392.
2. M. E. Jung, "Iodomethyl Methyl Ether," Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd., 1995.
3. M. E. Jung, "Trimethylsilyl iodide," Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd., 1995.
4. M. E. Jung, "1-Trimethylsilyloxy-1,3-butadiene," Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd., 1995.
5. M. E. Jung, "2-Trimethylsilyloxy-1,3-butadiene," Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd., 1995.
6. M. E. Jung, "Triphenylcarbenium Tetrafluoroborate," Encyclopedia of Reagents for Organic Synthesis, John Wiley & Sons, Ltd., 1995.
7. W. J. Wechter, E. D. Murray, Jr., D. Kantoci, and M. E. Jung, "Characterization of Two New Endogenous Natriuretic Factors," Abstract, 29th Annual Meeting, American Society of Neurology, November 1996.
8. Crostic No. 49 in Crostics, No. 115, Simon & Schuster, New York, NY, ed. T. H. Middleton, 1996.
9. S. E. Denmark, M. E. Jung, A. Pfaltz, B. Giese, "Laudio for Professor Doctor Albert Eschenmoser," Synlett 1999, III.
10.
M. E. Jung, "Tungsten Hexachloride," Encyclopedia
of Reagents for Organic Synthesis,
John Wiley
& Sons, Ltd., 2006.
MEETING ABSTRACTS
1. Richardson, J. A.;
Amantea, C. M.;
Nguyen, K.; Jung, M. E.; Hahn, T. J.; Parhami, F. "Characterization of
osteogenic oxysterols and their molecular mechanism(s) of
action," J. Bone Mineral Res.
2005, 20, S414-S415 Suppl.
1.
2. Wechter, W. J.;
Murray, E. D.; Kantoci, D.; Jung, M. E. "Characterization of two new
endogenous natriuretic
factors," J. Am.
Soc. Nephrol. 1996, 7, A2867-A2867.
SHORT COURSES
1. Nov. 1980: Upjohn Co., Kalamazoo, MI, "New Advances in the Use of Diels-Alder Reactions in Synthesis."
2. Sept. 1985: American Cyanamid Co., Agricultural Research Division, Princeton, NJ, "Silicon in Organic Synthesis."
3. Sept. 1987: Zhongshan University, Guangzhou, PRC, "Modern Organic Synthesis."
4. Sept. 1987: Zhongshan University, Guangzhou, PRC, "Silicon in Organic Synthesis."
5. April 1996: 3M, St. Paul, MN, "Strategy and Design in Organic Synthesis."
6. April 1998: 3M, St. Paul, MN, "New Methods in Heterocyclic Chemistry."
7. Dec. 1999: Neurocrine Biosciences, "Introduction to Modern Heterocyclic Chemistry."
8. Mar. 2003: Université Pierre et Marie Curie, Paris, "Modern Heterocyclic Chemistry."
9. May 2008:
Vertex, Inc., San Diego, "Modern Heterocyclic Chemistry."
PATENTS AND
APPLICATIONS
1. Cross, B.; Los, M.; Doehner, R. F., Jr.; Ladner, D. W.; Johnson, J. L.;
Jung, M. E.; Kamhi, V. M.; Tseng, S. S.; Finn, J. M.; Wepplo, P. J.
(Assignee: American Cyanamid Company) ÒPreparation of Novel Fused
Imidazolinylpyridines as Herbicides,Ó Eur. Pat. Appl. 1987, EP 227932 A1, CAN 108:21884.
2. Jung, M. E.; Gardiner, J. M. (Assignee: The Regents of the University of
California) ÒProcess for the Synthesis of 2Õ,3Õ-Dideoxynucleosides,Ó US
Patent 5,220,003 (June 15, 1993).
3. Cross, B.; Los, M.; Doehner, R. F., Jr.; Ladner, D. W.; Johnson, J. L.;
Jung, M. E.; Kamhi, V. M.; Tseng, S. S.; Finn, J. M.; Wepplo, P. J.
(Assignee: American Cyanamid Company) Ò(2-Imidazolin-2-yl) Fused Heteropyridine
Compounds, Intermediates for the Preparation of and Use of Said Compounds as
Herbicidal Agents,Ó US Patent 5,252,538 (October 12, 1993).
4. Harrington, P. E.; Jung, M. E. (Assignee: American Cyanamid Company) ÒStereoselective
Bromination of β-Ribofuranosyl
Amide: Synthesis of Herbicidal Analogues of Hydantocidin,Ó US Patent 5,354,868 (October 11, 1994).
5. Jung, M. E.; DÕAmico, D. C. (Assignee: The Regents of the University of California) ÒStereospecific
Synthesis of Aldols,Ó US Patent 5,426,206 (June 20, 1995).
6. Harrington, P. E.; Jung, M. E. (Assignee: American Cyanamid Company) ÒProcess and
Intermediates for the Preparation of (+)-Hydantocidin and Analogs Thereof,Ó US Patent
5,543,510 (August 6, 1996).
7. Jung, M. E.; Cook, P. D.; Kawasaki, A. M. (Assignee: Isis Pharmaceuticals) ÒMethod for
Removing Unreacted Electrophiles from a Reaction Mixture,Ó US Patent 5,632,898 (May 27, 1997).
8. Fraser, A. S.; Manoharan, M.; Cook, P. D.; Jung, M. E.; Kawasaki, A. M. (Assignee: Isis
Pharmaceuticals) ÒPreparation of DNA having improved hybridization affinity and nuclease
resistance via alkylation of nucleosides with cyclic sulfates,Ó US Patent 6,277,982
(August 21, 2001).
9. Manoharan, M.; Guzaev, A.; Jung, M. E.; Just, G.; Roland, A.; Wang, J. (Assignee: Isis Pharmaceuticals) ÒSolid
phase synthesis of alkylphosphonate-linked oligodeoxyribonucleotides,Ó US Patent 6,486,313 (November 26, 2002).
PCT Int. Appl. WO2000049032.
10. Jung, M. E.; Xu, Y. (Assignee: The Regents of the University of California) ÒSynthesis of L-Ribose and
2-Deoxy-L-Ribose from D-Ribose,Ó PCT Int. Appl. WO9839347, A2 19980911.
11. Manoharan, M.; Just, G.; Guzaev, A.; Roland, A.; Wang, J.; Jung, M. E. (Assignee:
Isis Pharmaceuticals) ÒOligonucleotides having alkylphosphonate linkages and methods for
their preparation,Ó US Patent 7,049,432 (May 23, 2006).
12. Finn, J.; Morytko, M.; Parr, I. B.; Jung, M. (Assignee: Cubist Pharmaceuticals)
ÒPreparation of novel depsipeptides as antibacterials,Ó PCT Int. Appl. WO200314147
A1 20030220.
13. Morytko, M.; Zhang, Y.; Jung, M.; Finn, J.; Bouchard, M. (Assignee: Cubist Pharmaceuticals)
ÒPreparation of lipopeptide stereoisomeric compounds as antibacterial agents,Ó
PCT Int. Appl. WO200317924, A2 20030306.
14. Sawyers, C. L.; Jung, M. E.; Chen, C. D.; Ouk, S.; Welsbie, D.; Tran, C.; Wongvipat, J.;
Yoo, D. (Assignee: The Regents of the University of California) ÒDiarylhydantoin
Compounds,Ó US Patent 7,709,517 (May 4, 2010).
15. Jung, M. E.; Ouk, S.; Sawyers, C. L.; Chen, C. D.; Welsbie, D. (Assignee: The Regents
of the University of California) ÒMethods and Materials for Assessing Prostate Cancer
Therapies and Compounds,Ó US Patent 7,718,684, (May 18, 2010).
16. Jung, M. E.; Ouk, S.; Sawyers, C. L.; Chen, C. D.; Welsbie, D. (Assignee: The Regents
of the University of California) ÒMethods and Materials for Assessing Prostate Cancer
Therapies and Compounds,Ó PCT Int. Appl. WO 2005099693 A2 20051027 CAN 143:432632
AN 2005:1154369.
17. Manoharan, M.; Jung, M. E.; Rajeev, K. G.; Pandey, R. K.; Wang, G. (Assignee:
Alnylam Pharmaceuticals) ÒProcesses and Reagents for Oligonucleotide Synthesis and
Purification,Ó US Patent Appl. 20050267300, (December 1, 2005).
18. Whitten, J. P.; Pierre, F.; Regan, C.; Schwaebe, M.; Yiannikouros, G. P.; Jung, M.
(Assignee: Cylene Pharmaceuticals) ÒMethod for Converting Quinolone Esters into Quinolone
Amides,Ó US Patent 7,652,134 (January 26, 2010).
19. Manoharan, M.; Jung, M. E.; Rajeev, K. G.; Pandey, R. K.; Wang, G. (Assignee: Alnylam
Pharmaceuticals) ÒProcess and Reagents for Oligonucleotide Synthesis and Purification,Ó
PCT Int. Appl. WO 2005097817, A2 20051020.
20. Manoharan, M.; Jung, M. E.; Rajeev, K. G.; Pandey, R. K.; Wang, G. (Assignee: Alnylam
Pharmaceuticals) ÒProcesses and Reagents for Desilylation of Oligonucleotides,Ó US Patent
Appl. 20090005549, (January 1, 2009).
21. Manoharan, M.; Jung, M. E.; Rajeev, K. G.; Pandey, R. K.; Wang, G. (Assignee: Alnylam
Pharmaceuticals) ÒProcesses and Reagents for Sulfurization of Oligonucleotides,Ó US
Patent Appl. 20090187027 (July 23, 2009).
22. Whitten, J. P.; Pierre, F.; Regan, C.; Schwaebe, M.; Yiannikouros, G. P.; Jung, M. E.
(Assignee: Cylene Pharmaceuticals) ÒPreparation of fused quinolone analogs which inhibit
cell proliferation and/or induce cell apoptosis,Ó US Patent Appl. 20060074089.
Cont.-in-part of U.S. Ser. No. 149,007. US 2006074089 A1 20060406 CAN 144:370091
AN 2006:322120.
23.Whitten, J. P.; Pierre, F.; Regan, C.; Schwaebe, M.; Yiannikouros, G. P.; Jung, M.
ÒPreparation of fused quinolone analogs which inhibit cell proliferation and/or induce
cell apoptosis,Ó PCT Int. Appl. WO 2006034113 A2 20060330 CAN 144:350684
AN 2006:301302.
24. Whitten, J. P.; Pierre, F.; Regan, C.; Schwaebe, M.; Yiannikouros, G. P.; Jung, M. E.;
Nagasawa, J. Y.; Chua, P. (Assignee: Cylene Pharmaceuticals) ÒProcess for the Preparation
of Benzothiazole and Phenoxazine Compounds,Ó US Patent Appl. 2006063761 A1 20060323
CAN 144:331460 AN 2006:273183.
25. Parhami, F.; Jung, M. E.; Dwyer, J. R.; Nguyen, K. (Assignee: The Regents of the
University of California) ÒOxysterol Compounds and the Hedgehog Pathway,Ó US Patent Appl.
20100034781 (February 11, 2010).
26. Sawyers, C. L.; Jung, M. E.; Chen, C. D.; Ouk, S.; Welsbie, D.; Tran, C.; Wongvipat, J.;
Yoo, D. (Assignee: The Regents of the University of California) ÒDiarylthiohydantoin
Compounds,Ó PCT Int. Appl. WO 2006124118 A1 20061123.
27. Parhami, F.; Jung, M. E.; Dwyer, J. R.; Nguyen, K. (Assignee: The Regents of the
University of California) ÒOxysterol Compounds and the Hedgehog Pathway,Ó PCT Int. Appl.
WO 2007098281 A2 20070830.
28. Jung, M. E.; Yoo, D.; Sawyers, C. L.; Tran, C. (Assignee: The Regents of the
University of California) ÒDiarylthiohydantoin Compounds,Ó US Patent Appl. 20070254933
A1 20071101.
29. Jung, M. E.; Yoo, D.; Sawyers, C. L.; Tran, C. (Assignee: The Regents of the
University of California) ÒDiarylthiohydantoin Compounds,Ó US Patent Appl. 20080139634.
30. Jung, M. E.; Sawyers, C. L.; Ouk, S.; Tran, C.; Wongvipat, J. (Assignee: The Regents
of the University of California) ÒAndrogen Receptor Modulators for the Treatment of Prostate
Cancer and Androgen Receptor-Associated Diseases,Ó PCT Int. Appl. WO 2007126765
A2 20071108.
31. Jung, M. E.; Yoo, D.; Sawyers, C. L.; Tran, C. "Diarylhydantoin Compounds as Androgen
Receptor Modulators,Ó (Assignee: The Regents of the University of California) PCT Int.
Appl. WO 2009055053 A2 20090430.
32. Sawyers, C. L.; Jung, M. E.; Yoo, D.; Tran, C. (Assignee: The Regents of the
University of California) "Diarylhydantoin Compounds,Ó US Patent Appl. 20090111864.
33. Parhami, F.; Jung, M. E.; Nguyen, K.; Yoo, D.; Kim, W.-K. (Assignee: The Regents of
the University of California) ÒOxysterols for Activation of Hedgehog Signaling,
Osteoinduction, Antiadipogenesis, and Wnt Signaling,Ó PCT Int. Appl. WO 2009073186
A1 20090611.
34. Lee, B; Jung, M. E.; Wolf, M. C.; Zhang, T. (Assignee: The Regents of the University
of California) ÒNovel Antiviral Agents for Enveloped Viruses,Ó PCT Int. Appl. WO
2010044924 A1 20100422.
35. Schiestl, R. H.; Rivina, Y. O.; Jung, M. E. (Assignee: The Regents of the University
of California) ÒCompounds for Mitigating Radiation-Induced Tissue Damage and Lethality,Ó
356115-v1-105837-4.
36. Jung, M. E.; Clubb, R. T.; Yi, S. W.; Suree, N.; Clemens, J. J. (Assignee: The Regents
of the University of California) "Sortase A Inhibitors," PCT Int. Appl. PCT/US10/46394.
37. Manoharan, M.; Rajeev, K. G.; Jayaraman, M.; Butler, D.; Jung, M. E. (Assignee:
Alnylam Pharmaceuticals) ÒLipid compositions for the delivery of nucleic acid
therapeutics,Ó PCT Int. Appl. WO 2010129709.
38. Parhami, F.; Kim, W.-K.; Jung, M. E.; Nguyen, K. (Assignee: The Regents of the
University of California) ÒInhibition of peroxisome proliferator activated receptor
gamma expression in preadipocyte cells by oxysterols,Ó PCT Int. Appl. WO 2011006087.
Summary: 13 issued patents; 25 patent applications (23 pending)
INVITED LECTURES
539 Lectures, seminars, and presentations at international and national chemical meetings and symposia, academic institutions, and industrial institutions from 1973-2011.